Protein Alignment Bace and REN

DIOPT Version :10

• Sequence 1: NP_609235.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_000528.1
• Gene: REN / 5972
• HGNCID: 9958
• Length: 406
• Species: Homo sapiens
• Alignment Length: 374
• Identity: 141/374 - (37%)
• Similarity: 209/374 - (55%)
• Gaps: 29/374 - (7%)

  Fly    19 LHRVPILKEQNFVKTRQNVLAEKSYLRTKYQLPSLR-----SVDEEQLSNSMNMAYYGAISIGTP 78
            |.|:|.::|.  :|.|.   .:.:.|..::..|..|     :.....|:|.|:..|||.|.||||
Human    36 LKRMPSIRES--LKERG---VDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTP 95

  Fly    79 AQSFKVLFDSGSSNLWVPSNTCKS--DACLTHNQYDSSASSTYVANGESFSIQYGTGSLTGYLST 141
            .|:|||:||:||||:||||:.|..  .||:.|..:|:|.||:|..||...:::|.||:::|:||.
Human    96 PQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQ 160

  Fly   142 DTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDGVAPPFYNMVSQGLVDNSVF 206
            |.:.|.|::: :|.|.|.|..|...|..|.|||::||.:...|:..|.|.|.|::|||::...||
Human   161 DIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVF 224

  Fly   207 SFYLARD--GTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGSSIDGYS-LCDD-CQA 267
            |||..||  .:.::||:::.||||...|.|...|:.:.:.|.||..|.|.|:...: ||:| |.|
Human   225 SFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLA 289

  Fly   268 IADTGTSLIVAPYNAYITLSEILNVGE---DGYLDCSSVSSLPDVTFNIGGTNFVLKPSAYIIQ- 328
            :.|||.|.|....::...|.|.|...:   |..:.|:...:|||::|::||..:.|..:.|:.|
Human   290 LVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQE 354

  Fly   329 ---SDGNCMSAFEYMGT-----DFWILGDVFIGQYYTEFDLGNNRIGFA 369
               |...|..|...|..     ..|.||..||.::|||||..|||||||
Human   355 SYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFA 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_609235.1	pepsin_retropepsin_like	59..369	CDD:472175	130/327 (40%)
REN	NP_000528.1	A1_Propeptide	33..>51	CDD:462326	6/19 (32%)
		renin_like	78..405	CDD:133154	132/327 (40%)