Protein Alignment Bace and Pga5

DIOPT Version :10

• Sequence 1: NP_609235.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_067428.2
• Gene: Pga5 / 58803
• MGIID: 1915935
• Length: 387
• Species: Mus musculus
• Alignment Length: 393
• Identity: 151/393 - (38%)
• Similarity: 221/393 - (56%)
• Gaps: 39/393 - (9%)

  Fly     8 VVLLAALASAELHRVPILKEQNFVKTRQNVLAE----KSYLRTKYQLPSLR-----------SVD 57
            |:.|.||:.. |.::|::|    :|:.:..|.|    |.||. ||  |..|           :|.
Mouse     6 VLGLVALSEC-LVKIPLMK----IKSMRENLRESQVLKDYLE-KY--PRSRAHVLLEQRRNPAVT 62

  Fly    58 EEQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVAN 122
            .|.:.|.:::.|.|.||||||.|.|:|:.|:|||.|||||..|.|.||..|..::...|||::.:
Mouse    63 YEPMRNYLDLVYIGIISIGTPPQEFRVVLDTGSSVLWVPSIYCSSPACAHHKAFNPLRSSTFLVS 127

  Fly   123 GESFSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDG 187
            |...::.||:|.::|:|:.|||.:..|::.:|.|..|..|||.....|.||||||:.|.:|.:.|
Mouse   128 GRPVNVAYGSGEMSGFLAYDTVRIGDLTVVAQAFGLSLEEPGIFMEYAVFDGILGLGYPNLGLQG 192

  Fly   188 VAPPFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMA 252
            :.|.|.|:..|||:..::|:|||:  .....|..|:.||.|.|.|.|.|.:||:|:..|||..:.
Mouse   193 ITPVFDNLWLQGLIPQNLFAFYLS--SKDEKGSMLMLGGVDPSYYHGELHWVPVSKPSYWQLAVD 255

  Fly   253 GSSIDGYSL-CD-DCQAIADTGTSLIVAPYNAYITLSEILNVGEDG----YLDCSSVSSLPDVTF 311
            ..|::|..: || .||.|.||||||:..|.::.:.:..::.....|    :|.|.::::|||:.|
Mouse   256 SISMNGEVIACDGGCQGIMDTGTSLLTGPRSSIVNIQNLIGAKASGDGEYFLKCDTINTLPDIVF 320

  Fly   312 NIGGTNFVLKPSAYIIQS-DGNCMSAFEYMGTD------FWILGDVFIGQYYTEFDLGNNRIGFA 369
            .||...:.:..||||.:. ..||.|.|| .|.|      .|:|||||:..|:|.||..|||||.|
Mouse   321 TIGSVTYPVPASAYIRKDRSHNCRSNFE-EGMDDPSDPEMWVLGDVFLRLYFTVFDRANNRIGLA 384

  Fly   370 PVA 372
            |.|
Mouse   385 PAA 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_609235.1	pepsin_retropepsin_like	59..369	CDD:472175	130/322 (40%)
Pga5	NP_067428.2	A1_Propeptide	18..44	CDD:462326	8/30 (27%)
		pepsin_retropepsin_like	64..385	CDD:472175	130/323 (40%)