DRSC/TRiP Functional Genomics Resources

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Protein Alignment Bace and BACE1

DIOPT Version :10

Sequence 1:NP_609235.1 Gene:Bace / 34182 FlyBaseID:FBgn0032049 Length:372 Species:Drosophila melanogaster
Sequence 2:NP_036236.1 Gene:BACE1 / 23621 HGNCID:933 Length:501 Species:Homo sapiens


Alignment Length:389 Identity:101/389 - (25%)
Similarity:156/389 - (40%) Gaps:82/389 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 QLPSLRSVDEE---------------QLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSN 98
            :||  |..|||               .|.......||..:::|:|.|:..:|.|:||||..|.: 
Human    42 RLP--RETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGA- 103

  Fly    99 TCKSDACLTHNQYDSSASSTYVANGESFSIQYGTGSLTGYLSTDTVDV-NGLSIQSQTFAESTNE 162
               :.....|..|....||||....:...:.|..|...|.|.||.|.: :|.::..:....:..|
Human   104 ---APHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITE 165

  Fly   163 PGTNF-NDANFDGILGMAYESLA--VDGVAPPFYNMVSQGLVDNSVFSFYLARDG--------TS 216
            ....| |.:|::||||:||..:|  .|.:.|.|.::|.|..|.| :||..|...|        .:
Human   166 SDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPN-LFSLQLCGAGFPLNQSEVLA 229

  Fly   217 TMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGSSIDGYSLCDDC------QAIADTGTSL 275
            ::||.:|.||.|.|||:|:|.|.||..:.|::..:....|:|..|..||      ::|.|:||:.
Human   230 SVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTN 294

  Fly   276 IVAPYNAYITLSEILNVGEDGYLDCSSVSSLPD--------VTFNIGGTNF-------------- 318
            :..|       .::...........||....||        |.:..|.|.:              
Human   295 LRLP-------KKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEV 352

  Fly   319 -------------VLKPSAYIIQSDGNCMSAFEYMGTDFWILGDVFIGQYYTEFDLGNNRIGFA 369
                         .|:|...:..|..:|........:...::|.|.:..:|..||....|||||
Human   353 TNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BaceNP_609235.1 pepsin_retropepsin_like 59..369 CDD:472175 94/377 (25%)
BACE1NP_036236.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..58 6/17 (35%)
beta_secretase_like 72..437 CDD:133140 94/357 (26%)
Interaction with RTN3 479..501
DXXLL. /evidence=ECO:0000269|PubMed:15886016 496..500
Blue background indicates that the domain is not in the aligned region.

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