DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment emb and CRM1

DIOPT Version :9

Sequence 1:	NP_001303316.1	Gene:	emb / 34167	FlyBaseID:	FBgn0020497	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	NP_011734.3	Gene:	CRM1 / 853133	SGDID:	S000003450	Length:	1084	Species:	Saccharomyces cerevisiae

Alignment Length:	1082	Identity:	463/1082 - (42%)
Similarity:	690/1082 - (63%)	Gaps:	37/1082 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLDFSQKLDINLLDKIVEVVYTAQGEQLRLAQSILTTLKEHPEAWTRVDSILEYSQNQRTKFYAL 77
            :||||..|||.|||::|...|...|.|.:.||.|||..:::|:||.:.|.||::|.|.::||.||
Yeast     4 ILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAWQKADQILQFSTNPQSKFIAL 68

  Fly    78 QILEEVIKTRWKVLPRNQCEGIKKYVVSLIIKTSSDPIVMEQNKVYLNKLNMILVHILKREWPRN 142
            .||:::|..:||:||.:...||:.:||.:||....|..|.:..|..:||.::.||.|||:|||:|
Yeast    69 SILDKLITRKWKLLPNDHRIGIRNFVVGMIISMCQDDEVFKTQKNLINKSDLTLVQILKQEWPQN 133

  Fly   143 WETFISDIVGASKTNESLCMNNMVILKNLSEEVFDFSQGQITQTKAKHLKDTMCSEFSQIFTLCS 207
            |..||.:::|:|.::.::|.|||::||.|||||||||..|:||.||.|||::|..||.|||.||.
Yeast   134 WPEFIPELIGSSSSSVNVCENNMIVLKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCF 198

  Fly   208 FVLENSMNAALIHVTLETLLRFLNWIPLGYIFETQQIETLIFKFLSVPMFRNVTLKCLSEIAGLT 272
            .|||...:::||..|||:|||:|:|||..||:||..:|.|..||::.|..|.:|||||:|::.|.
Yeast   199 QVLEQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPDTRAITLKCLTEVSNLK 263

  Fly   273 AANYDE----NFATLFKDTMVQL-EQIVGQNMNMNHVFKHGSDTEQELVLNLAMFLCTFLKEHGK 332
            ....::    .....|::|:.|: ..::....::...:.:.:..:|..:.:|||||.|:|..:..
Yeast   264 IPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLKATYANANGNDQSFLQDLAMFLTTYLARNRA 328

  Fly   333 LVE-DAKYVDYLNQALMYLVMISEVEDVEVFKICLEYWNSLVEDLYNSEFFHPTLESTKRQQV-- 394
            |:| |....:.|..|..||:.:|::|:.|:||..|:||::||.||:......|..|.:...|:
Yeast   329 LLESDESLRELLLNAHQYLIQLSKIEERELFKTTLDYWHNLVADLFYEVQRLPATEMSPLIQLSV 393

  Fly   395 -------------------YP-RRRFYAPILSKVRFIMISRMAKPEEVLVVENENGEVVREFMKD 439
                               :| ::..|..|.|::|.::|..|.:|||||||||:.||:||||:|:
Yeast   394 GSQAISTGSGALNPEYMKRFPLKKHIYEEICSQLRLVIIENMVRPEEVLVVENDEGEIVREFVKE 458

  Fly   440 TNSINLYKNMRETLVFLTHLDSVDTDRIMTLKLLNQVNGSEFSWKNLNTLCWAIGSISGAFCEED 504
            :::|.|||:.||.||:||||:.:||:.||..||..|::|||:||.|:|||.||||||||...|:.
Yeast   459 SDTIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDGSEWSWHNINTLSWAIGSISGTMSEDT 523

  Fly   505 EKRFLVTVIKDLLGLCEQKKGKDNKAIIASNIMYVVGQYPRFLRAHWKFLKTVVNKLFEFMHETH 569
            ||||:||||||||.|..:|:||||||::||:||||||||||||:|||.||:||:.||||||||||
Yeast   524 EKRFVVTVIKDLLDLTVKKRGKDNKAVVASDIMYVVGQYPRFLKAHWNFLRTVILKLFEFMHETH 588

  Fly   570 DGVQDMACDTFIKIAIKCRRYFVTIQPNEACTFIDEILTTMSSIICDLQPQQVHTFYEAVGYMIS 634
            :|||||||||||||..||:.:||..||.|:..||..|:..:.....|||||||||||:|.|.:||
Yeast   589 EGVQDMACDTFIKIVQKCKYHFVIQQPRESEPFIQTIIRDIQKTTADLQPQQVHTFYKACGIIIS 653

  Fly   635 AQVDQVQQDVLIERYMQLPNQVWDDIISRASKNVDFLKNMTAVKQLGSILKTNVAACKALGHAYV 699
            .:....:::.|:...|||||..||.|:.:::.|...|.:...||.:.:|:|||||.|.::|..:.
Yeast   654 EERSVAERNRLLSDLMQLPNMAWDTIVEQSTANPTLLLDSETVKIIANIIKTNVAVCTSMGADFY 718

  Fly   700 IQLGRIYLDMLNVYKITSENIIQAIEVNGVNVNNQPLIKTMHVVKKETLNLISEWVSRSNDNQLV 764
            .|||.||.:||.:|:..|..|...:...|:.....|.::.:..:|||.|.|:..::|::.:...|
Yeast   719 PQLGHIYYNMLQLYRAVSSMISAQVAAEGLIATKTPKVRGLRTIKKEILKLVETYISKARNLDDV 783

  Fly   765 MDNFIPPLLDAILLDYQRCKVPSAREPKVLSAMAIIVHKLRQHITNEVPKIFDAVFECTLDMINK 829
            :...:.|||:|:|.||.. .||.||:.:||:.|..:|.|:...|...|..|..:|||||||||||
Yeast   784 VKVLVEPLLNAVLEDYMN-NVPDARDAEVLNCMTTVVEKVGHMIPQGVILILQSVFECTLDMINK 847

  Fly   830 NFEDFPQHRLSFYELLQAVNAHCFKAFLNIPPAQFKLVFDSVVWAFKHTMRNVADMGLNILFKML 894
            :|.::|:||:.||:||:.:|...|.|||.:|||.|||..|::.|||||..|:|...||.|...::
Yeast   848 DFTEYPEHRVEFYKLLKVINEKSFAAFLELPPAAFKLFVDAICWAFKHNNRDVEVNGLQIALDLV 912

  Fly   895 QNLDQHPGA--AQSFYQTYFTDILMQIFSVVTDTSHTAGLPNHAIILAYMFSLVENRKITVNL-- 955
            :|:::....  |..|::.||...:.:.|.|:||:.|.:|....|::|..:.|||.:.||:|.|
Yeast   913 KNIERMGNVPFANEFHKNYFFIFVSETFFVLTDSDHKSGFSKQALLLMKLISLVYDNKISVPLYQ 977

  Fly   956 -GPIP---DNMIFIQEYVASLLKSAFTHLSDNQVKVFVTGLFNLDENVQAFKEHLRDFLIQIREA 1016
             ..:|   .|.:::.:|:|::|.:||.||:..|:..|::.|....:::..||..|||||:||:|.
Yeast   978 EAEVPQGTSNQVYLSQYLANMLSNAFPHLTSEQIASFLSALTKQYKDLVVFKGTLRDFLVQIKEV 1042

  Fly  1017 TGEDDSDLYLEEREAALAEEQSNKHQMQRNIPGMLNPHELPE 1058
            .|:....|:.|::|.||.|:...:.:....|.|:|.|.||.:
Yeast  1043 GGDPTDYLFAEDKENALMEQNRLEREKAAKIGGLLKPSELDD 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
emb	NP_001303316.1	CRM1	13..1023	CDD:227432	451/1045 (43%)
		IBN_N	43..109	CDD:197981	29/65 (45%)
		Xpo1	120..265	CDD:285575	76/144 (53%)
		CRM1_C	701..1015	CDD:285920	120/321 (37%)
CRM1	NP_011734.3	CRM1	1..1070	CDD:227432	457/1066 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343210
Domainoid	1	1.000	233	1.000	Domainoid score	I400
eggNOG	1	0.900	-	-		E1_COG5101
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2554
Inparanoid	1	1.050	890	1.000	Inparanoid score	I44
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53807
OrthoFinder	1	1.000	-	-		FOG0003578
OrthoInspector	1	1.000	-	-		oto100090
orthoMCL	1	0.900	-	-		OOG6_101697
Panther	1	1.100	-	-	LDO	PTHR11223
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R13754
SonicParanoid	1	1.000	-	-		X2450
TreeFam	1	0.960	-	-
	15	14.790