Protein Alignment emb and CRM1

DIOPT Version :10

• Sequence 1: NP_723391.2
• Gene: emb / 34167
• FlyBaseID: FBgn0020497
• Length: 1063
• Species: Drosophila melanogaster
• Sequence 2: NP_011734.3
• Gene: CRM1 / 853133
• SGDID: S000003450
• Length: 1084
• Species: Saccharomyces cerevisiae
• Alignment Length: 1082
• Identity: 463/1082 - (42%)
• Similarity: 690/1082 - (63%)
• Gaps: 37/1082 - (3%)

  Fly    13 LLDFSQKLDINLLDKIVEVVYTAQGEQLRLAQSILTTLKEHPEAWTRVDSILEYSQNQRTKFYAL 77
            :||||..|||.|||::|...|...|.|.:.||.|||..:::|:||.:.|.||::|.|.::||.||
Yeast     4 ILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAWQKADQILQFSTNPQSKFIAL 68

  Fly    78 QILEEVIKTRWKVLPRNQCEGIKKYVVSLIIKTSSDPIVMEQNKVYLNKLNMILVHILKREWPRN 142
            .||:::|..:||:||.:...||:.:||.:||....|..|.:..|..:||.::.||.|||:|||:|
Yeast    69 SILDKLITRKWKLLPNDHRIGIRNFVVGMIISMCQDDEVFKTQKNLINKSDLTLVQILKQEWPQN 133

  Fly   143 WETFISDIVGASKTNESLCMNNMVILKNLSEEVFDFSQGQITQTKAKHLKDTMCSEFSQIFTLCS 207
            |..||.:::|:|.::.::|.|||::||.|||||||||..|:||.||.|||::|..||.|||.||.
Yeast   134 WPEFIPELIGSSSSSVNVCENNMIVLKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCF 198

  Fly   208 FVLENSMNAALIHVTLETLLRFLNWIPLGYIFETQQIETLIFKFLSVPMFRNVTLKCLSEIAGLT 272
            .|||...:::||..|||:|||:|:|||..||:||..:|.|..||::.|..|.:|||||:|::.|.
Yeast   199 QVLEQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPDTRAITLKCLTEVSNLK 263

  Fly   273 AANYDE----NFATLFKDTMVQL-EQIVGQNMNMNHVFKHGSDTEQELVLNLAMFLCTFLKEHGK 332
            ....::    .....|::|:.|: ..::....::...:.:.:..:|..:.:|||||.|:|..:..
Yeast   264 IPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLKATYANANGNDQSFLQDLAMFLTTYLARNRA 328

  Fly   333 LVE-DAKYVDYLNQALMYLVMISEVEDVEVFKICLEYWNSLVEDLYNSEFFHPTLESTKRQQV-- 394
            |:| |....:.|..|..||:.:|::|:.|:||..|:||::||.||:......|..|.:...|:
Yeast   329 LLESDESLRELLLNAHQYLIQLSKIEERELFKTTLDYWHNLVADLFYEVQRLPATEMSPLIQLSV 393

  Fly   395 -------------------YP-RRRFYAPILSKVRFIMISRMAKPEEVLVVENENGEVVREFMKD 439
                               :| ::..|..|.|::|.::|..|.:|||||||||:.||:||||:|:
Yeast   394 GSQAISTGSGALNPEYMKRFPLKKHIYEEICSQLRLVIIENMVRPEEVLVVENDEGEIVREFVKE 458

  Fly   440 TNSINLYKNMRETLVFLTHLDSVDTDRIMTLKLLNQVNGSEFSWKNLNTLCWAIGSISGAFCEED 504
            :::|.|||:.||.||:||||:.:||:.||..||..|::|||:||.|:|||.||||||||...|:.
Yeast   459 SDTIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDGSEWSWHNINTLSWAIGSISGTMSEDT 523

  Fly   505 EKRFLVTVIKDLLGLCEQKKGKDNKAIIASNIMYVVGQYPRFLRAHWKFLKTVVNKLFEFMHETH 569
            ||||:||||||||.|..:|:||||||::||:||||||||||||:|||.||:||:.||||||||||
Yeast   524 EKRFVVTVIKDLLDLTVKKRGKDNKAVVASDIMYVVGQYPRFLKAHWNFLRTVILKLFEFMHETH 588

  Fly   570 DGVQDMACDTFIKIAIKCRRYFVTIQPNEACTFIDEILTTMSSIICDLQPQQVHTFYEAVGYMIS 634
            :|||||||||||||..||:.:||..||.|:..||..|:..:.....|||||||||||:|.|.:||
Yeast   589 EGVQDMACDTFIKIVQKCKYHFVIQQPRESEPFIQTIIRDIQKTTADLQPQQVHTFYKACGIIIS 653

  Fly   635 AQVDQVQQDVLIERYMQLPNQVWDDIISRASKNVDFLKNMTAVKQLGSILKTNVAACKALGHAYV 699
            .:....:::.|:...|||||..||.|:.:::.|...|.:...||.:.:|:|||||.|.::|..:.
Yeast   654 EERSVAERNRLLSDLMQLPNMAWDTIVEQSTANPTLLLDSETVKIIANIIKTNVAVCTSMGADFY 718

  Fly   700 IQLGRIYLDMLNVYKITSENIIQAIEVNGVNVNNQPLIKTMHVVKKETLNLISEWVSRSNDNQLV 764
            .|||.||.:||.:|:..|..|...:...|:.....|.::.:..:|||.|.|:..::|::.:...|
Yeast   719 PQLGHIYYNMLQLYRAVSSMISAQVAAEGLIATKTPKVRGLRTIKKEILKLVETYISKARNLDDV 783

  Fly   765 MDNFIPPLLDAILLDYQRCKVPSAREPKVLSAMAIIVHKLRQHITNEVPKIFDAVFECTLDMINK 829
            :...:.|||:|:|.||.. .||.||:.:||:.|..:|.|:...|...|..|..:|||||||||||
Yeast   784 VKVLVEPLLNAVLEDYMN-NVPDARDAEVLNCMTTVVEKVGHMIPQGVILILQSVFECTLDMINK 847

  Fly   830 NFEDFPQHRLSFYELLQAVNAHCFKAFLNIPPAQFKLVFDSVVWAFKHTMRNVADMGLNILFKML 894
            :|.::|:||:.||:||:.:|...|.|||.:|||.|||..|::.|||||..|:|...||.|...::
Yeast   848 DFTEYPEHRVEFYKLLKVINEKSFAAFLELPPAAFKLFVDAICWAFKHNNRDVEVNGLQIALDLV 912

  Fly   895 QNLDQHPGA--AQSFYQTYFTDILMQIFSVVTDTSHTAGLPNHAIILAYMFSLVENRKITVNL-- 955
            :|:::....  |..|::.||...:.:.|.|:||:.|.:|....|::|..:.|||.:.||:|.|
Yeast   913 KNIERMGNVPFANEFHKNYFFIFVSETFFVLTDSDHKSGFSKQALLLMKLISLVYDNKISVPLYQ 977

  Fly   956 -GPIP---DNMIFIQEYVASLLKSAFTHLSDNQVKVFVTGLFNLDENVQAFKEHLRDFLIQIREA 1016
             ..:|   .|.:::.:|:|::|.:||.||:..|:..|::.|....:::..||..|||||:||:|.
Yeast   978 EAEVPQGTSNQVYLSQYLANMLSNAFPHLTSEQIASFLSALTKQYKDLVVFKGTLRDFLVQIKEV 1042

  Fly  1017 TGEDDSDLYLEEREAALAEEQSNKHQMQRNIPGMLNPHELPE 1058
            .|:....|:.|::|.||.|:...:.:....|.|:|.|.||.:
Yeast  1043 GGDPTDYLFAEDKENALMEQNRLEREKAAKIGGLLKPSELDD 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
emb	NP_723391.2	CRM1	13..1023	CDD:227432	451/1045 (43%)
CRM1	NP_011734.3	CRM1	1..1070	CDD:227432	457/1066 (43%)