Protein Alignment emb and Xpo6

DIOPT Version :10

• Sequence 1: NP_723391.2
• Gene: emb / 34167
• FlyBaseID: FBgn0020497
• Length: 1063
• Species: Drosophila melanogaster
• Sequence 2: XP_017167830.1
• Gene: Xpo6 / 74204
• MGIID: 2429950
• Length: 1140
• Species: Mus musculus
• Alignment Length: 1324
• Identity: 246/1324 - (18%)
• Similarity: 435/1324 - (32%)
• Gaps: 481/1324 - (36%)

  Fly    17 SQKLDINLLDKIVEVVY--TAQGEQLRLAQSILTTLKEHPEAWTRVDSILEYSQNQRTKFYALQI 79
            |::..:..|:.::...:  ....|:.|..:.:|....:...||......|..::|.....|:|.:
Mouse     3 SEEASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQVGAWRFCLYFLSSTRNDYVMMYSLTV 67

  Fly    80 LEEVIKTRWKVLPRNQCEGIKKYVVSLII---KTSSDPIVMEQNKVYLNKLNMILVHILKREWPR 141
            .|.:|...|..:|......|:..:..|::   ||.  |..:.      |||..::|.|.:::||.
Mouse    68 FENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTL--PYFIR------NKLCKVIVDIGRQDWPM 124

  Fly   142 NWETFISDIVGASKTNESLCMNNMVILKNLSEEVFDFSQGQITQTKAKHLKDTMCSEFSQIFTLC 206
            .:..|.::|:...::..:..: .:::||..|||: ...:..::..:.:.|:..:..:...:..|.
Mouse   125 FYHDFFTNILQLIQSPVTTPL-GLIMLKTTSEEL-ACPREDLSVARKEELRKLLLDQVQTVLGLL 187

  Fly   207 SFVLE-----NSMNAA--------------------------LIH---------------VTLET 225
            :.:||     :|:.||                          |:|               :.||.
Mouse   188 TGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLHQPIPILDVESEYVCSLALEC 252

  Fly   226 LLRFLNWIPLGYIFETQQIETLIFKF------------------------------LSVPMFRNV 260
            |....:||||.... |..:.|.||.|                              |.|     :
Mouse   253 LAHLFSWIPLSASI-TPSLLTTIFHFARFGCDTRARKMASVNGSSQNCVLGQERGRLGV-----L 311

  Fly   261 TLKCLSEIAGLTAA--NYDENFATLFKDTMVQLEQIVGQNMNMNHVFKH---------GSDTEQE 314
            .:.|::|:......  .::|....:|:.|...|::|...  |..|..|.         ||:.:.|
Mouse   312 AMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKD--NNAHTVKSRLEELDESPGSEVKAE 374

  Fly   315 LVLNLAMFLCTFLKEHGKLVEDAKYVDYLNQALMYLVMISEVEDVEVFKICLEYWNSLVEDLYNS 379
            ..|....::             .|:.|:|.  |...|.:..:|....|.: :|:    :..|:..
Mouse   375 RCLEAESYI-------------EKFTDFLR--LFVSVHLRRIESYSQFPV-VEF----LTLLFKY 419

  Fly   380 EFFHPTLES--------TKRQQVYPRRRFYAPILSKVRFIMISRMAKPEEV----------LVVE 426
            .|..||.|.        |         .|...:.||::    ||:...|.|          |:.|
Mouse   420 TFHQPTHEGYFSCLDIWT---------LFLDYLTSKIK----SRLGDKEAVLNRYEDALVLLLTE 471

  Fly   427 NEN-----------GEVVREFMKDTNSINLYKNMRETL-VFLTHLDSVDTDRIMTLKLLNQVN-- 477
            ..|           .|:..|.:.|.......:.:|::| |....::.:.|....||..:.|.|
Mouse   472 VLNRIQFRYNQAQLEELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLE 536

  Fly   478 ------------GS---------------EFSWKNLNTLCWAIGSISGAFC-EEDEKRF--LVTV 512
                        ||               ..|.::|::|..|:|.::..|. :....||  .:||
Mouse   537 VYLGLQQFVVTSGSGHRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFIGDVFAARFNDALTV 601

  Fly   513 IKDLLGLCEQKKGKDNK---------AIIASNIMYVVGQYPRFLRA--HWKFLKTVVNKLFEFMH 566
            ::.|:.:  ...|...|         :::..:::.|..|....|:|  ||         |.::..
Mouse   602 VERLVKV--TLYGSQIKLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHW---------LAQYCG 655

  Fly   567 ETHDGVQDMACDTFIKIAIKCRRYFVTIQPNEACTFIDEILTTMSSIICDLQPQQVHTFYEAVGY 631
            |.|.               :..:.|||:           |.|||                :|:..
Mouse   656 EAHR---------------QNTQQFVTL-----------ISTTM----------------DAITP 678

  Fly   632 MISAQVDQVQQDVLIERYMQLPNQVWDDIISRASK-NVDFLKNMTAV-KQLGSIL---------K 685
            :||.:|    ||.|:.....|       ::|.|:. ...||.::.|| |...||:         |
Mouse   679 LISTKV----QDKLLLSACHL-------LVSLATTVRPVFLISIPAVQKVFNSIIDASAQRLTDK 732

  Fly   686 TNVAACKALGHAYVIQLGRIYLDMLNVYKITSENIIQAIEVNGVNVNNQPLIKTMHVVKKETLNL 750
            ..|..|:||                                     :|..|:...::.:.|
Mouse   733 AQVLVCRAL-------------------------------------SNTLLLPWPNLPESE---- 756

  Fly   751 ISEWVSRSNDNQLVMDNFIPPLLDAILLDYQRCKVPSAREP--KV-LSAMAIIVHK-------LR 805
             .:|..||.::        ..|:.|:..||...| |||..|  || |....:|:|:       :.
Mouse   757 -QQWPLRSINH--------ASLISALSRDYHSLK-PSATAPQRKVPLGDTKVIIHQTLSVLEDIV 811

  Fly   806 QHITNEVPKIFDAVFECTLDMINKNFEDFP---------QHRLSFYELLQAVNAHCFKAF---LN 858
            ::|:.|..|.....::...:.:..:...||         ...|||:..|       |:..   :.
Mouse   812 ENISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTL-------FRGLRVQMG 869

  Fly   859 IPPAQFKLVFDSVVWAFKH--TMRNVAD-------MGLNIL---FKMLQNLDQHPG--------- 902
            :|      ..:.::..|.:  |...:|:       .|..::   .|:||.:.|.||
Mouse   870 VP------FTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPS 928

  Fly   903 -AAQSFYQTY-------FTDILMQIFSVVTDTSH---------------TAGLPNH--------- 935
             .|....|.|       ..|:..::|.::..|.|               ..|:...
Mouse   929 IIALCMEQVYPIIAERPSPDVKAELFELLFRTLHHNWRYFFKSTVLASVQRGIAEEQMENEPQFS 993

  Fly   936 AIILAYMFSLVENRKITVNLGPIPDNMIFIQE--YVASL-LKSAFTHLSDNQVKVF-VTGLF--- 993
            ||:.|:..|.::           ||..:|.|.  |:.:| .|....|     .|:| .|.||
Mouse   994 AIMQAFGQSFLQ-----------PDIHLFKQNLFYLETLNTKQKLYH-----KKIFRTTMLFQFV 1042

  Fly   994 NLDENVQAFKEHLRDFL-----IQIREATGEDDSDLYLEEREAALAEE-----------QSN--- 1039
            |:...|...|.|  |.|     |.|......|....:     ||...|           |.|
Mouse  1043 NVLLQVLVHKSH--DLLQEEIGIAIYNMASVDFDGFF-----AAFLPEFLTSCDGVDANQKNVLG 1100

  Fly  1040 -KHQMQRNIPGML-NPHELPEDMQ 1061
             ..:|.|::|... |.|.|..|::
Mouse  1101 RNFKMDRDLPSFTQNVHRLVNDLR 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
emb	NP_723391.2	CRM1	13..1023	CDD:227432	234/1268 (18%)
Xpo6	XP_017167830.1	IBN_N	31..96	CDD:197981	13/64 (20%)
		Xpo1	103..277	CDD:462459	35/182 (19%)