DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment emb and Xpo5

DIOPT Version :9

Sequence 1:	NP_001303316.1	Gene:	emb / 34167	FlyBaseID:	FBgn0020497	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	NP_001102259.2	Gene:	Xpo5 / 363194	RGDID:	1311522	Length:	1204	Species:	Rattus norvegicus

Alignment Length:	1054	Identity:	200/1054 - (18%)
Similarity:	374/1054 - (35%)	Gaps:	285/1054 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ILEYSQNQRTKFYALQILEEVIKTRWKVLPRNQCEGIKKYVVSLIIKTSSDPIVMEQNKVYLNKL 127
            :.|.:|....:.:.|||||.|:|.||..:.|.:...:|..|:.||...:.. |:.|:|.: .:.|
  Rat    54 LAEKTQIAIVRHFGLQILEHVVKFRWNSMSRLEKVYLKNSVMELIANGTLS-ILEEENHI-KDVL 116

  Fly   128 NMILVHILKREWPRNWETFISDIVGASKTNESLCMNNMVILKNLSEEVFDFS------QGQITQT 186
            :.|:|.::|||||::|...:.::...|:..|:.....|.||..|:|:|..|.      :..|.||
  Rat   117 SRIVVEMIKREWPQHWPDMLMELDTLSRQGETQRELVMFILLRLAEDVVTFQTLPTQRRRDIQQT 181

  Fly   187 KAKHLKDTM----------CSEFSQIFTLCSFVLENSMNAALIHVTLETLLRFLNWIPLGYIF-- 239
            ..::::..:          .:::.|:.|..|...|...|..:....|.||..:::|:.|.:|.
  Rat   182 LTQNMERILNFLLSTLQENVNKYQQMKTDASQEAEAQANCRVSIAALNTLAGYIDWVSLNHITAE 246

  Fly   240 ETQQIETLIFKFLSVPMFRNVTLKCLSEIAGLTAANYDENFATLFKDTMVQLEQIVGQNMNMNHV 304
            ..:.:|||                ||.                                  :|
  Rat   247 NCKLVETL----------------CLL----------------------------------LN-- 259

  Fly   305 FKHGSDTEQELVLNLAMFLCTFLKEHGKLVEDAKYVDYL--NQALMYLVMISEVED----VEVFK 363
                   ||||.|..|..|...:...||| ||.|.:..|  :.|:.|::..::..|    ||...
  Rat   260 -------EQELQLGAAECLLIAVSRKGKL-EDRKRLMILFGDVAMHYVLSAAQTADGGGLVEKHY 316

  Fly   364 ICLE-------------------------------YWNS-LVEDLYNSEFF----HPTLESTKRQ 392
            :.|:                               |..| |....:.|:|.    |.|..:..|.
  Rat   317 LFLKRLCQVLCALGNLLCALLALDANIQTPVNFGMYLESFLAFTTHPSQFLRSSTHMTWGALFRH 381

  Fly   393 QVYPRRRFYAPILSKVRFIMISRMAKPEEVLVVENENGEVVR-EFMKDTNSINLYKNMR----ET 452
            :|..|......::.|.....::.:.|.......::.:.|..| :|..|.:....:.:.|    |.
  Rat   382 EVLSRDPSLLAVIPKYLRASMTNLVKMGFPSKTDSPSCEYSRFDFDSDEDFNAFFNSSRAQHGEV 446

  Fly   453 LVFLTHLDSVDTDRIMTLKLLNQVNGSEFSWKNLNTLCWAIGSISGAFCE---------EDEKRF 508
            :..:..||. .|...|..:.|.....:......:|: |...|:..|.||.         |....|
  Rat   447 VRCVCRLDP-KTSFQMAAEWLKYQLSAAIDTGPVNS-CSTAGTGEGGFCSIFSPSYVQWEAMTFF 509

  Fly   509 LVTVIKDLLGLCEQKKGKDNKAI---------------IASNIMYVVGQYPRFLRAHWKFLKTVV 558
            |.:||..:....|:::...|:.|               |.|.::..|.....|:.....||..|.
  Rat   510 LESVINQMFRTLEKEELPVNEGIELLQLVLNFEMKDPLILSCVLTNVSALFPFVTYKPAFLPQVF 574

  Fly   559 NKLFEFMHETHDGVQDM--------------ACDTFIKIAIKCRRYFVTIQPNEACTFIDEILTT 609
            :|||.|:  |.:.|.:.              ||.:..|:   ||.|...:.||     .|.:.:.
  Rat   575 SKLFSFV--TFESVGESKAPRTRAVRNVRRHACSSINKM---CRDYPDLVLPN-----FDMLYSH 629

  Fly   610 MSSIICD---LQPQQVHTFYEAVGYMISAQVDQVQQDVLIERYMQLPNQVW-DDIISRASKNVDF 670
            :..::.:   |...:.....||:..:.:...|..:|.:.:|..|.....:| .:.:.||..::|
  Rat   630 VKQLLSNELLLTQMEKCALMEALVLVSNQFKDYERQKLFLEELMAPVVNIWLSEEMCRALSDID- 693

  Fly   671 LKNMTAVKQLGSILKT-NVAACKALGHAYVIQLGRIYLDMLNVYKI-------TSENIIQAIEVN 727
                ..:..:|:.||: :.||....|      |.|..:... ||.|       |..:.::..:..
  Rat   694 ----AFIAYVGADLKSCDPAAQDPCG------LNRARMSFC-VYSILGVMRRTTWPSDLEEAKAG 747

  Fly   728 GVNV----NNQPLIKTMHVVKKETLNLISEWVSRSNDNQLVMDN-----FIPPLLDAI------- 776
            |..|    :..|:.:          |..:|.:.|..||.|.:..     :.|.:|..:
  Rat   748 GFVVGYTPSGNPVFR----------NPCTEQILRLLDNLLALVRTHNTLYTPEMLTKMAEPFTKA 802

  Fly   777 --LLDYQRCKVPSAREPKVLSAMAIIVHKLRQHITNEVPKIFDAVFECTLDMINKNFEDFPQHRL 839
              :::.::..:....:|    .:.|..|.:.:.|...:.:.|..::|....::.|   ..|..:.
  Rat   803 LDIVESEKTAILGLPQP----LLEINDHPVYRTILERMQRFFGILYENCYHILGK---AGPSMQQ 860

  Fly   840 SFYELLQAVNAHCFKAFLNIPPAQFKLVFDSVVWAFKHTMRNVADMGLNILFK------MLQNLD 898
            .||.:..........||:|                    :.|:.|..|..:.:      :|....
  Rat   861 DFYTVEDLATQLLGSAFVN--------------------LNNIPDFRLRSMLRVFVKPLVLFCPP 905

  Fly   899 QHPGAAQSFYQTYFTDILMQIFSVVTDTSHTAGLPNHAIILAYMFSLVENRKITVNLGPI----P 959
            :|       |:|..:.||..:|:.:           | :.|:..:.::..|.:......|    |
  Rat   906 EH-------YETLISPILGPLFTYL-----------H-MRLSQKWHVINQRSVLCGEDEIAEDNP 951

  Fly   960 DNMIFIQEYVASLL 973
            ::...::|.:..:|
  Rat   952 ESQEMLEEQLVRML 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
emb	NP_001303316.1	CRM1	13..1023	CDD:227432	200/1054 (19%)
		IBN_N	43..109	CDD:197981	16/45 (36%)
		Xpo1	120..265	CDD:285575	36/162 (22%)
		CRM1_C	701..1015	CDD:285920	47/308 (15%)
Xpo5	NP_001102259.2	IBN_N	33..100	CDD:197981	16/45 (36%)
Xpo5	NP_001102259.2	Xpo1	109..271	CDD:285575	45/221 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40069at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910