DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment emb and crm1

DIOPT Version :9

Sequence 1:	NP_001303316.1	Gene:	emb / 34167	FlyBaseID:	FBgn0020497	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	NP_001342911.1	Gene:	crm1 / 3361487	PomBaseID:	SPAC1805.17	Length:	1078	Species:	Schizosaccharomyces pombe

Alignment Length:	1077	Identity:	526/1077 - (48%)
Similarity:	744/1077 - (69%)	Gaps:	30/1077 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLDFSQKLDINLLDKIVEVVYTAQGEQLRLAQSILTTLKEHPEAWTRVDSILEYSQNQRTKFYAL 77
            :|.|.::||:.|||::|:..|...|.:.:.||.:||..:.||:||::..||||.|:..:||:.||
pombe     4 ILAFDRELDVALLDRVVQTFYQGVGAEQQQAQQVLTQFQAHPDAWSQAYSILEKSEYPQTKYIAL 68

  Fly    78 QILEEVIKTRWKVLPRNQCEGIKKYVVSLIIKTSSDPIVMEQNKVYLNKLNMILVHILKREWPRN 142
            .:|:::|.||||:||:.|..||:.|:|:::||.|||..|::|.|.:||||::.||.|||:|||.|
pombe    69 SVLDKLITTRWKMLPKEQRLGIRNYIVAVMIKNSSDETVLQQQKTFLNKLDLTLVQILKQEWPHN 133

  Fly   143 WETFISDIVGASKTNESLCMNNMVILKNLSEEVFDFSQGQITQTKAKHLKDTMCSEFSQIFTLCS 207
            |..||.:||.|||||.|||.|||::|:.||||:||:|..|:||.|.|:||:.||.||::||.|||
pombe   134 WPNFIPEIVQASKTNLSLCENNMIVLRLLSEEIFDYSAEQMTQLKTKNLKNQMCGEFAEIFQLCS 198

  Fly   208 FVLENSMNAALIHVTLETLLRFLNWIPLGYIFETQQIETLIFKFLSVPMFRNVTLKCLSEIAGLT 272
            .:||.:...:||..||.|||||||||||||||||..:|.:..:||:||.|||||::||:|||.||
pombe   199 QILERAQKPSLIKATLGTLLRFLNWIPLGYIFETNIVELITNRFLNVPDFRNVTIECLTEIASLT 263

  Fly   273 A-ANYDENFATLFKDTMVQLEQIVGQNMNMNHVFKHGSDTEQELVLNLAMFLCTFLKEHGKLVED 336
            : ..|::.|.|:|...|..:..::....:....::..|..||:.:.|||:|||.|...|.:.:|:
pombe   264 SQPQYNDKFVTMFNLVMTSVNSMLPLQTDFREAYEESSTNEQDFIQNLALFLCAFFSSHLRPLEN 328

  Fly   337 AKYVDYLNQALMYLVMISEVEDVEVFKICLEYWNSLVEDLYN-------SEFFHPTLESTKRQQV 394
            .:..:.|..|..||:.||.:.:.|:||||||||:.||..||.       || .:|.|..:....:
pombe   329 PENQEVLLNAHSYLLNISRINEREIFKICLEYWSKLVAQLYEEMQQIPMSE-MNPLLNLSSPTSL 392

  Fly   395 YP-----------RRRFYAPILSKVRFIMISRMAKPEEVLVVENENGEVVREFMKDTNSINLYKN 448
            ..           |:..|..|||.:|.:||..|.||||||:|||:.||:||||:|:|::|.|||:
pombe   393 ISSNPNMLANLPLRKHIYKDILSTLRLVMIENMVKPEEVLIVENDEGEIVREFVKETDTITLYKS 457

  Fly   449 MRETLVFLTHLDSVDTDRIMTLKLLNQVNGSEFSWKNLNTLCWAIGSISGAFCEEDEKRFLVTVI 513
            |||.||:|||||.|||:.:||.||...|.|:|:||:|||||||||||||||..||.||||||.||
pombe   458 MREVLVYLTHLDVVDTEIVMTEKLARIVVGTEWSWQNLNTLCWAIGSISGAMNEEMEKRFLVNVI 522

  Fly   514 KDLLGLCEQKKGKDNKAIIASNIMYVVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACD 578
            ||||||||.|:||||||::|||||||||||||||:|||||||||||||||||||.|:||||||||
pombe   523 KDLLGLCEMKRGKDNKAVVASNIMYVVGQYPRFLKAHWKFLKTVVNKLFEFMHEYHEGVQDMACD 587

  Fly   579 TFIKIAIKCRRYFVTIQPNEACTFIDEILTTMSSIICDLQPQQVHTFYEAVGYMISAQVDQVQQD 643
            ||||||.||||:||..|..|...||:||:..::....||.|||.||||||.|||||||..:..|:
pombe   588 TFIKIAQKCRRHFVAQQLGETEPFINEIIRNLAKTTEDLTPQQTHTFYEACGYMISAQPQKHLQE 652

  Fly   644 VLIERYMQLPNQVWDDIISRASKNVDFLKNMTAVKQLGSILKTNVAACKALGHAYVIQLGRIYLD 708
            .||...|.||||.|::|:::|::|...|.:...||.|.::||||||||.::|..:..|:.:.|:|
pombe   653 RLIFDLMALPNQAWENIVAQAAQNAQVLGDPQTVKILANVLKTNVAACTSIGSGFYPQIAKNYVD 717

  Fly   709 MLNVYKITSENIIQAIEVNGVNVNNQPLIKTMHVVKKETLNLISEWVSRSNDNQLVMDNFIPPLL 773
            ||.:||..|..|.:.:...|......|.::.:..:|||.|.|:..::||:.|.:||.:..||.|.
pombe   718 MLGLYKAVSGLISEVVAAQGNIATKTPHVRGLRTIKKEILKLVDAYISRAEDLELVGNTLIPALF 782

  Fly   774 DAILLDYQRCKVPSAREPKVLSAMAIIVHKLRQHITNEVPKIFDAVFECTLDMINKNFEDFPQHR 838
            :|:||||.: .||.||:.:||:.:..||::|.:.:|:::|.:.||||.|||:||:|:|.::|:||
pombe   783 EAVLLDYLQ-NVPDARDAEVLNLITTIVNQLSELLTDKIPLVLDAVFGCTLEMISKDFSEYPEHR 846

  Fly   839 LSFYELLQAVNAHCFKAFLNIPPAQFKLVFDSVVWAFKHTMRNVADMGLNILFKMLQNL-DQHPG 902
            .:|::||:|:|.:||.|.||||..|||||.:|:||:|||..|::.:.|||||.:::.|: ...|.
pombe   847 AAFFQLLRAINLNCFPALLNIPAPQFKLVINSIVWSFKHVSRDIQETGLNILLELINNMASMGPD 911

  Fly   903 AAQSFYQTYFTDILMQIFSVVTDTSHTAGLPNHAIILAYMFSLVENRKITVNL---GPIP---DN 961
            .:.:|:|||:..:|..|..|:||:.|.:|....::|||.:|.|||:.:|||.|   ...|   :|
pombe   912 VSNAFFQTYYISLLQDILYVLTDSDHKSGFKLQSLILARLFYLVESNQITVPLYDPSQFPQEMNN 976

  Fly   962 MIFIQEYVASLLKSAFTHLSDNQVKVFVTGLFNLDENVQAFKEHLRDFLIQIREATGEDDSDLYL 1026
            .:|:::|:.:||.:||.||...|::.||..:..|:::...||..|||||||::| .|.|:::|||
pombe   977 QLFLRQYIMNLLVTAFPHLQPIQIQEFVQTVLALNQDSIKFKLALRDFLIQLKE-FGGDNAELYL 1040

  Fly  1027 EEREAALAEEQSNKHQMQRNIPGMLNPHELPEDMQDE 1063
            ||:|..||.:|..:.:....:|||:.|.::| .|::|
pombe  1041 EEKEQELAAQQKAQLEKAMTVPGMIKPVDMP-TMEEE 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
emb	NP_001303316.1	CRM1	13..1023	CDD:227432	510/1035 (49%)
		IBN_N	43..109	CDD:197981	30/65 (46%)
		Xpo1	120..265	CDD:285575	87/144 (60%)
		CRM1_C	701..1015	CDD:285920	130/320 (41%)
crm1	NP_001342911.1	CRM1	1..1052	CDD:227432	518/1050 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	263	1.000	Domainoid score	I359
eggNOG	1	0.900	-	-		E1_COG5101
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2554
Inparanoid	1	1.050	1022	1.000	Inparanoid score	I32
OMA	1	1.010	-	-		QHG53807
OrthoFinder	1	1.000	-	-		FOG0003578
OrthoInspector	1	1.000	-	-		oto101825
orthoMCL	1	0.900	-	-		OOG6_101697
Panther	1	1.100	-	-	LDO	PTHR11223
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R13754
SonicParanoid	1	1.000	-	-		X2450
TreeFam	1	0.960	-	-
	14	13.860