Protein Alignment emb and Xpo6

DIOPT Version :10

• Sequence 1: NP_723391.2
• Gene: emb / 34167
• FlyBaseID: FBgn0020497
• Length: 1063
• Species: Drosophila melanogaster
• Sequence 2: NP_001011935.2
• Gene: Xpo6 / 293476
• RGDID: 1311491
• Length: 1125
• Species: Rattus norvegicus
• Alignment Length: 1259
• Identity: 223/1259 - (17%)
• Similarity: 420/1259 - (33%)
• Gaps: 366/1259 - (29%)

  Fly    17 SQKLDINLLDKIVEVVY--TAQGEQLRLAQSILTTLKEHPEAWTRVDSILEYSQNQRTKFYALQI 79
            |:...:..|:.::...:  ....|:.|..:.:|....:...||......|..::|.....|:|.:
  Rat     3 SEDASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQVGAWRFCLYFLSSTRNDYVMMYSLTV 67

  Fly    80 LEEVIKTRWKVLPRNQCEGIKKYVVSLII---KTSSDPIVMEQNKVYLNKLNMILVHILKREWPR 141
            .|.:|...|..:|......|:..:..|::   ||.  |..:.      |||..::|.|.:::||.
  Rat    68 FENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTL--PYFIR------NKLCKVIVDIGRQDWPM 124

  Fly   142 NWETFISDIVGASKTNESLCMNNMVILKNLSEEVFDFSQGQITQTKAKHLKDTMCSEFSQIFTLC 206
            .:..|.::|:...::..:..: .:::||..|||: ...:..::..:.:.|:..:..:...:..|.
  Rat   125 FYHDFFTNILQLIQSPVTTPL-GLIMLKTTSEEL-ACPREDLSVARKEELRKLLLDQVQTVLGLL 187

  Fly   207 SFVLE-----NSMNAA--------------------------LIH---------------VTLET 225
            :.:||     :|:.||                          |:|               :.||.
  Rat   188 TGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLHQPIPILDVESEYVCSLALEC 252

  Fly   226 LLRFLNWIPLGYIFETQQIETLIFKF------------------------------LSVPMFRNV 260
            |....:||||.... |..:.|.||.|                              |.|     :
  Rat   253 LAHLFSWIPLSASI-TPSLLTTIFHFARFGCDTRARKMASVNGSSQNCVLGQERGRLGV-----L 311

  Fly   261 TLKCLSEIAGLTAA--NYDENFATLFKDTMVQLEQIVGQNMNMNHVFKHGSDTEQELVLNLAMFL 323
            .:.|::|:......  .::|....:|:.|...|::|...| |.:.|.....:.::..|.....||
  Rat   312 AMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDN-NAHTVKSRLEELDESYVEKFTDFL 375

  Fly   324 CTFLKEHGKLVEDAKYVDYLNQALMYLVMISEVEDVEVFKICLEYWNSLVEDLYNSEFFHPTLES 388
            ..|:..|.:.:|.......|....:...........|.:..||:.|...::.|
  Rat   376 RLFVSVHLRRIESYSQFPVLEFLTLLFKYTFHQPTHEGYFSCLDIWTLFLDYL------------ 428

  Fly   389 TKRQQVYPRRRFYAPILSKVRFIMISRMAKPEEV----------LVVENEN-----------GEV 432
                            .||::    ||:...|.|          |:.|..|           .|:
  Rat   429 ----------------TSKIK----SRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQLEEL 473

  Fly   433 VREFMKDTNSINLYKNMRETL-VFLTHLDSVDTDRIMTLKLLNQVN--------------GS--- 479
            ..|.:.|.......:.:|::| |....::.:.|....||..:.|.|              ||
  Rat   474 DDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVYLGLQQFVVTSGSGHR 538

  Fly   480 ------------EFSWKNLNTLCWAIGSISGAFC-EEDEKRF--LVTVIKDLLGLCEQKKGKDNK 529
                        ..|.::|::|..|:|.::..|. :....||  .:||::.|:.:  ...|...|
  Rat   539 LNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFTGDVFAARFSDALTVVERLVKV--TLYGSQIK 601

  Fly   530 ---------AIIASNIMYVVGQYPRFLRA--HWKFLKTVVNKLFEFMHETH-DGVQDMACDTFIK 582
                     :::..:::.|..|....|:|  ||         |.::..|.| ...|...  |.|.
  Rat   602 LYNIETAVPSVLKPDLIDVHAQSLAALQAYSHW---------LAQYCSEAHRQNTQQFV--TLIS 655

  Fly   583 IAIKCRRYFVTIQPNE-----ACTFIDEILTTMSSIICDLQPQQVHTFYEAVGYMISAQVDQVQ- 641
            ..:......::.:..:     ||..:..:.||:..:.....|.....|...:........|:.|
  Rat   656 TTMDAITPLISTKVQDKLLLSACHLLVSLATTVRPVFLISIPAMQKVFNSIIDASAQRLTDKAQV 720

  Fly   642 ------QDVLIERYMQLP--NQVWD-------DIISRASKNVDFLKNMTAVKQLGSILKTNVAAC 691
                  .:.|:..:..||  .|.|.       .:||..|::...||...|..|    .|..:...
  Rat   721 LVCRALSNTLLLPWPNLPESEQQWPLRSINHASLISALSRDYHSLKPSAAAPQ----RKMPLDDT 781

  Fly   692 KALGHAYVIQLGRIYLDMLNVYKITSENIIQAIEVNGVNVNN-----QPLIKTMHVVKKETLNLI 751
            |.:.|           ..|:|::...|||      :|.:..:     |.|.:::.|    :|.|.
  Rat   782 KVIIH-----------QTLSVFEDIVENI------SGESTKSRQICYQSLQESVQV----SLALF 825

  Fly   752 SEWVSRSNDNQLVMDNFIP-----------PLLDAILLDYQR------------------CKVPS 787
            ..::.:|:....::..|:.           |..:.|:..:..                  |:|..
  Rat   826 PAFIHQSDVTDEMLSFFLTLFRGLRVQMGVPFTEQIIQTFLNMFTREQLAESILHEGSTGCRVVE 890

  Fly   788 AREPKVLSAMAIIVHKLRQHITNEVPKIFDAVFECTLDMINKNFEDFPQHRLSFYELLQAVNAHC 852
                |.|..:.::|.:..|.....:|.|.....|....:|.:  ...|..:...:|||.....|.
  Rat   891 ----KFLKILQVVVQEPGQVFKPFLPSIIALCMEQVYPIIAE--RPSPDVKAELFELLFRTLHHN 949

  Fly   853 FKAFLNIPPAQFKLVFDSVVWAFKHTMRNVADMGLNILFKMLQNLDQHPGAAQSFYQTYF-TDIL 916
            ::.|           |.|.|.|  ...|.:|:       :.::|..|.....|:|.|::. .||
  Rat   950 WRYF-----------FKSTVLA--SVQRGIAE-------EQMENEPQFSAIMQAFGQSFLQPDI- 993

  Fly   917 MQIFSVVTDTSHTAGLPNHAIILAYMFSLVENRKITVNLGPIPDNMIFIQEYVASLLKSAFTH-- 979
             .:|.           .|    |.|:.:|...:|: .:.......|:|  ::|..||: ...|
  Rat   994 -HLFK-----------QN----LFYLETLNTKQKL-YHKKIFRTTMLF--QFVNVLLQ-VLVHKS 1038

  Fly   980 --LSDNQVKVFVTGLFNLDENVQAFKEHLRDFLIQIREATGEDDSDLYLEEREAALAEEQSN--- 1039
              |...::.:.:..:.::|.: ..|...|.:||      |..|..|           ..|.|
  Rat  1039 HDLLQEEIGIAIYNMASVDFD-GFFAAFLPEFL------TSCDGVD-----------ANQKNVLG 1085

  Fly  1040 -KHQMQRNIPGML-NPHELPEDMQ 1061
             ..:|.|::|... |.|.|..|::
  Rat  1086 RNFKMDRDLPSFTQNVHRLVNDLR 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
emb	NP_723391.2	CRM1	13..1023	CDD:227432	213/1214 (18%)
Xpo6	NP_001011935.2	IBN_N	31..96	CDD:197981	13/64 (20%)
		Xpo1	103..277	CDD:462459	35/182 (19%)