Protein Alignment emb and XPO6

DIOPT Version :10

• Sequence 1: NP_723391.2
• Gene: emb / 34167
• FlyBaseID: FBgn0020497
• Length: 1063
• Species: Drosophila melanogaster
• Sequence 2: NP_055986.1
• Gene: XPO6 / 23214
• HGNCID: 19733
• Length: 1125
• Species: Homo sapiens
• Alignment Length: 1305
• Identity: 231/1305 - (17%)
• Similarity: 427/1305 - (32%)
• Gaps: 458/1305 - (35%)

  Fly    17 SQKLDINLLDKIVEVVY--TAQGEQLRLAQSILTTLKEHPEAWTRVDSILEYSQNQRTKFYALQI 79
            |::..:..|:.::...:  ....|:.|..:.:|....:...||......|..::|.....|:|.:
Human     3 SEEASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTV 67

  Fly    80 LEEVIKTRWKVLPRNQCEGIKKYVVSLII---KTSSDPIVMEQNKVYLNKLNMILVHILKREWPR 141
            .|.:|...|..:|......|:..:..|::   ||.  |..:.      |||..::|.|.:::||.
Human    68 FENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTL--PYFIR------NKLCKVIVDIGRQDWPM 124

  Fly   142 NWETFISDIVGASKTNESLCMNNMVILKNLSEEVFDFSQGQITQTKAKHLKDTMCSEFSQIFTLC 206
            .:..|.::|:...::..:..: .:::||..|||: ...:..::..:.:.|:..:..:...:..|.
Human   125 FYHDFFTNILQLIQSPVTTPL-GLIMLKTTSEEL-ACPREDLSVARKEELRKLLLDQVQTVLGLL 187

  Fly   207 SFVLE-----NSMNAA-----------------------------------------LIHVTLET 225
            :.:||     :|:.||                                         :..:.||.
Human   188 TGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLNQPIPILDVESEYICSLALEC 252

  Fly   226 LLRFLNWIPLGYIFETQQIETLIFKF------------------------------LSVPMFRNV 260
            |....:||||.... |..:.|.||.|                              |.|     :
Human   253 LAHLFSWIPLSASI-TPSLLTTIFHFARFGCDIRARKMASVNGSSQNCVSGQERGRLGV-----L 311

  Fly   261 TLKCLSEIAGLTAA--NYDENFATLFKDTMVQLEQIVGQNMNMNHVFKHGSDTEQELVLNLAMFL 323
            .:.|::|:......  .::|....:|:.|...|::|...| |.:.|.....:.::..:.....||
Human   312 AMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDN-NAHTVKSRLEELDESYIEKFTDFL 375

  Fly   324 CTFLKEHGKLVEDAK---YVDYLNQALMYLVMISEVEDVEVFKICLEYWNSLVEDLYNSEFFHPT 385
            ..|:..|.:.:|...   .|::|.....|..   .....|.:..||:.|...::.|
Human   376 RLFVSVHLRRIESYSQFPVVEFLTLLFKYTF---HQPTHEGYFSCLDIWTLFLDYL--------- 428

  Fly   386 LESTKRQQVYPRRRFYAPILSKVRFIMISRMAKPEEV----------LVVENEN----------- 429
                               .||::    ||:...|.|          |:.|..|
Human   429 -------------------TSKIK----SRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQL 470

  Fly   430 GEVVREFMKDTNSINLYKNMRETL-VFLTHLDSVDTDRIMTLKLLNQVN--------------GS 479
            .|:..|.:.|.......:.:|::| |....::.:.|....||..:.|.|              ||
Human   471 EELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVYLGLQQFIVTSGS 535

  Fly   480 ---------------EFSWKNLNTLCWAIGSISGAFC-EEDEKRF--LVTVIKDLLGLCEQKKGK 526
                           ..|.::|::|..|:|.::..|. :....||  .:||::.|:.:  ...|.
Human   536 GHRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFIGDVFAARFNDALTVVERLVKV--TLYGS 598

  Fly   527 DNK---------AIIASNIMYVVGQYPRFLRA--HWKFLKTVVNKLFEFMHETHDGVQDMACDTF 580
            ..|         :::..:::.|..|....|:|  ||         |.::..|.|.
Human   599 QIKLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHW---------LAQYCSEVHR---------- 644

  Fly   581 IKIAIKCRRYFVTIQPNEACTFIDEILTTMSSIICDLQPQQVHTFYEAVGYMISAQVDQVQQDVL 645
                 :..:.|||:           |.|||                :|:..:||.:|    ||.|
Human   645 -----QNTQQFVTL-----------ISTTM----------------DAITPLISTKV----QDKL 673

  Fly   646 IERYMQLPNQVWDDIISRASK-NVDFLKNMTAVKQ----------LGSILKTNVAACKALGHAYV 699
            :.....|       ::|.|:. ...||.::.||::          |..:.|..|..|:||.
Human   674 LLSACHL-------LVSLATTVRPVFLISIPAVQKVFNRITDASALRLVDKAQVLVCRALS---- 727

  Fly   700 IQLGRIYLDMLNVYKITSENIIQAIEVNGVNVNNQPLIKTMHVVKKETLNLISEWVSRSNDNQLV 764
                       |:..:...|:.:         |.|                  :|..||.::
Human   728 -----------NILLLPWPNLPE---------NEQ------------------QWPVRSINH--- 751

  Fly   765 MDNFIPPLLDAILLDYQRCKVPSAREPK---VLSAMAIIVHK-------LRQHITNEVPKIFDAV 819
                 ..|:.|:..||:..| |||..|:   .|....:|:|:       :.::|:.|..|.....
Human   752 -----ASLISALSRDYRNLK-PSAVAPQRKMPLDDTKLIIHQTLSVLEDIVENISGESTKSRQIC 810

  Fly   820 FECTLDMINKNFEDFP---------QHRLSFYELLQAVNAHCFKAF---LNIPPAQFKLVFDSVV 872
            ::...:.:..:...||         ...|||:..|       |:..   :.:|      ..:.::
Human   811 YQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTL-------FRGLRVQMGVP------FTEQII 862

  Fly   873 WAFKH--TMRNVAD-------MGLNIL---FKMLQNLDQHPG----------AAQSFYQTY---- 911
            ..|.:  |...:|:       .|..::   .|:||.:.|.||          .|....|.|
Human   863 QTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPSIIALCMEQVYPIIA 927

  Fly   912 ---FTDILMQIFSVVTDTSH---------------TAGLPNH---------AIILAYMFSLVENR 949
               ..|:..::|.::..|.|               ..|:...         ||:.|:..|.::
Human   928 ERPSPDVKAELFELLFRTLHHNWRYFFKSTVLASVQRGIAEEQMENEPQFSAIMQAFGQSFLQ-- 990

  Fly   950 KITVNLGPIPDNMIFIQE--YVASL-LKSAFTHLSDNQVKVFVTGLF----NLDENVQAFKEHLR 1007
                     ||..:|.|.  |:.:| .|....|     .|:|.|.:.    |:...|...|.|
Human   991 ---------PDIHLFKQNLFYLETLNTKQKLYH-----KKIFRTAMLFQFVNVLLQVLVHKSH-- 1039

  Fly  1008 DFL-----IQIREATGEDDSDL-------YLEEREAALAEEQS---NKHQMQRNIPGML-NPHEL 1056
            |.|     |.|......|....       :|...:...|.::|   ...:|.|::|... |.|.|
Human  1040 DLLQEEIGIAIYNMASVDFDGFFAAFLPEFLTSCDGVDANQKSVLGRNFKMDRDLPSFTQNVHRL 1104

  Fly  1057 PEDMQ 1061
            ..|::
Human  1105 VNDLR 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
emb	NP_723391.2	CRM1	13..1023	CDD:227432	221/1254 (18%)
XPO6	NP_055986.1	IBN_N	31..96	CDD:197981	13/64 (20%)
		Xpo1	103..253	CDD:462459	24/157 (15%)