Protein Alignment fy and FUZ

DIOPT Version :10

• Sequence 1: NP_477500.1
• Gene: fy / 34166
• FlyBaseID: FBgn0001084
• Length: 416
• Species: Drosophila melanogaster
• Sequence 2: NP_001339191.1
• Gene: FUZ / 80199
• HGNCID: 26219
• Length: 419
• Species: Homo sapiens
• Alignment Length: 440
• Identity: 128/440 - (29%)
• Similarity: 210/440 - (47%)
• Gaps: 69/440 - (15%)

  Fly     2 SIYLLCLTTNGGLPVFTR-KKGEC---ENLPFSTVASLNGFHMFFKSLGIQLEATTTSKQQPIQN 62
            :::||||..:.|:|:|.| .:|..   :.||||.:.||||.|||.::|.:||.:..|
Human     9 TVHLLCLAASSGVPLFCRSSRGGAPARQQLPFSVIGSLNGVHMFGQNLEVQLSSART-------- 65

  Fly    63 QAPADAEEWTYIWRD-RESITLIVCGCGVG-SEQLLQTLADLVFGAIGMFITRAAEMAHATLLDR 125
                  |..|.:|:. .:||||||....|| ||..|:.|..:||||: :.:....|:.:...::|
Human    66 ------ENTTVVWKSFHDSITLIVLSSEVGISELRLERLLQMVFGAM-VLLVGLEELTNIRNVER 123

  Fly   126 LKKDAKKYVPIVDAILEAACAGTQLLG----YTDCLLAAENAQLLQCLNEFSGHCGSLFCCLVVG 186
            ||||.:....::|:.|    ..::|:|    ..||::..|.:.|.:.|:.|:...|:.|..|||.
Human   124 LKKDLRASYCLIDSFL----GDSELIGDLTQCVDCVIPPEGSLLQEALSGFAEAAGTTFVSLVVS 184

  Fly   187 HRIAVATEGWWDLDTRDRELLLFLLNS-SSTMQHDVPVYLPVKSPHIAYRFVSIPVASNSALCVL 250
            .|:..||||||.|.|.:..||.:|:.| ......|.|||||..||.:.:|.:::.:..:..||:|
Human   185 GRVVAATEGWWRLGTPEAVLLPWLVGSLPPQTARDYPVYLPHGSPTVPHRLLTLTLLPSLELCLL 249

  Fly   251 CGAENASFRELHAHAMSAYRNEGNLLAAAERCV---PRSLPEHLEIDGNVLAIILINRHTRKSLF 312
            || .:....:|:...:..:...  ||.....|:   ||:||....:..::|.::|::...::.||
Human   250 CG-PSPPLSQLYPQLLERWWQP--LLDPLRACLPLGPRALPSGFPLHTDILGLLLLHLELKRCLF 311

  Fly   313 TRNLNQSASVKRIIVGDL------QRLDILKKFFDQTMDAVHQFETQSSSNKTTLVDQYSCSDYH 371
            |        |:.:  ||.      ||..:|:.|:  |:.....|..:....:.|..:.|......
Human   312 T--------VEPL--GDKAEPSPEQRRRLLRNFY--TLVTSTHFPPEPGPPEKTEDEVYQAQLPR 364

  Fly   372 KCYAHMD-------------ELG-NVIFLLFVAAVPSHAMRFLA-QRIHA 406
            .||..:.             :|| ..:.||.....|:|.:|.|| ..:||
Human   365 ACYLVLGTEEPGTGVRLVALQLGLRRLLLLLSPQSPTHGLRSLATHTLHA 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fy	NP_477500.1	Fuzzy	5..410	CDD:411043	128/437 (29%)
FUZ	NP_001339191.1	Fuzzy	12..417	CDD:411043	128/437 (29%)