DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PGAP5 and CDC1

DIOPT Version :9

Sequence 1:	NP_609191.1	Gene:	PGAP5 / 34116	FlyBaseID:	FBgn0031997	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_010468.1	Gene:	CDC1 / 851763	SGDID:	S000002590	Length:	491	Species:	Saccharomyces cerevisiae

Alignment Length:	345	Identity:	80/345 - (23%)
Similarity:	149/345 - (43%)	Gaps:	57/345 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RFLYACFVIVLCALIFCEYVADFVVLQKCKWPEIKRKKYVDDPLRAMILADPHLLG-------PH 59
            |::...:::.|..:.:.|.|.....::||:|...:......:..|..:.|||.::.       |.
Yeast    45 RYISIVWILWLGLISYYESVVVKRAMKKCQWSTWEDWPEGAESHRVGLFADPQIMDEYSYPGRPQ 109

  Fly    60 RGHWLDKLYREWHMTRAFQAASRLFQPDVVFVLGDLFDEGDMVSDKQFQEYVWRYLKMFHLPPGI 124
            ..::..::..:.:..|.::.......||..|.||||||.|....|||:.:...|:.::|   |..
Yeast   110 IVNYFTRVIVDHYHRRNWKYVQYYLDPDSNFFLGDLFDGGRNWDDKQWIKEYTRFNQIF---PKK 171

  Fly   125 PL----ISVAGNHDVGFHYKMHPFFMSRFESYLNNSSVNL----YTIKQIHFVVINSMAMEGDGC 181
            ||    :|:.||||:||...:....:.||.||...:|.:|    :|     ||:::::::
Yeast   172 PLRRTVMSLPGNHDIGFGDTVVESSLQRFSSYFGETSSSLDAGNHT-----FVLLDTISL----- 226

  Fly   182 MFCTQAEDQLKNISRT--LYCMKYPLEAECARTRRHPYSQPILLQHFPTYRISDTM-C---EEHD 240
                 ::....|:||.  .:...:.:.:       ||..: |||.|.|.:|..:.. |   .|..
Yeast   227 -----SDKTNPNVSRVPRQFLDNFAMGS-------HPLPR-ILLTHVPLWRDPEQQTCGQLRESK 278

  Fly   241 APY-IEAFRERFHVLSKDATDMLGELLKPRLAFAGHSHHFC---HSVNRLG----IDEYTVASFS 297
            .|: |:...:...|:..|.:..:...::|.:.|:|..|..|   ||....|    ..|.||.|.:
Yeast   279 EPFPIQKGHQYQTVIENDISQEILTKIQPEILFSGDDHDHCQISHSYPFQGKTKNAQEITVKSCA 343

  Fly   298 WRNKVN-PSFMLATI-TPDD 315
            ....:: |:..|.:: .|.|
Yeast   344 MNMGISRPAIQLLSLYNPSD 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PGAP5	NP_609191.1	Metallophos	45..279	CDD:278574	61/255 (24%)
PGAP5	NP_609191.1	MPP_MPPE1	48..301	CDD:277372	68/281 (24%)
CDC1	NP_010468.1	MPP_Cdc1	91..347	CDD:277370	68/281 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I2732
eggNOG	1	0.900	-	-		E1_KOG3662
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	65	1.000	Inparanoid score	I1739
Isobase	1	0.950	-	0	Normalized mean entropy	S3042
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003247
OrthoInspector	1	1.000	-	-		oto100259
orthoMCL	1	0.900	-	-		OOG6_104282
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1923
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.740