DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rbsn-5 and RBSN

DIOPT Version :10

Sequence 1:NP_609186.1 Gene:Rbsn-5 / 34110 FlyBaseID:FBgn0261064 Length:505 Species:Drosophila melanogaster
Sequence 2:NP_071735.2 Gene:RBSN / 64145 HGNCID:20759 Length:784 Species:Homo sapiens


Alignment Length:522 Identity:158/522 - (30%)
Similarity:253/522 - (48%) Gaps:75/522 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 GEILEGFLCPICRADLKSIDVLTDHFARQHA-EEEDALKSFKDIFTKAKK---KILNPFEDEKGA 77
            ||:.||||||:|..||:|...|..|:..:|: |:.|.....|.:..||||   ::|....|::..
Human     8 GEVREGFLCPLCLKDLQSFYQLHSHYEEEHSGEDRDVKGQIKSLVQKAKKAKDRLLKREGDDRAE 72

  Fly    78 SVSSPAGSSSSAAGKNPNGNGDRNGPSNARSRLNVFNYM-ARQQPGAECSHFEYFQSIRNPRLER 141
            | .:....|.|..|.:|                    || ..|:.||..||...|:..|..|::.
Human    73 S-GTQGYESFSYGGVDP--------------------YMWEPQELGAVRSHLSDFKKHRAARIDH 116

  Fly   142 YASETNKLIIRLHRL--LKDLPADSVQRRQHEQQTVAWLDGSSVKLCPSCAKSFHIARRQHHCRL 204
            |..|.|||||||.:|  ......:|.:.|..|:..|.|::...|..||.|...|.|..|:|||||
Human   117 YVVEVNKLIIRLEKLTAFDRTNTESAKIRAIEKSVVPWVNDQDVPFCPDCGNKFSIRNRRHHCRL 181

  Fly   205 CGGIMCNDCSKFLPLEDAMQLASLS----TTRSEPLQ---QLH-------------------QHE 243
            ||.|||..|.:.:.|..|.:|.|.|    :|.:.|.|   .:|                   :.:
Human   182 CGSIMCKKCMELISLPLANKLTSASKESLSTHTSPSQSPNSVHGSRRGSISSMSSVSSVLDEKDD 246

  Fly   244 NAIRLCEHCLWLLDTRKDMHESRTCRPLLVQVYEQIRQLQKEVTPDLDMYLKIINSLNEGDTIFT 308
            :.||.|.||...|..|:...:.:...|.:|::||::|...::|......|:::..|||.|:|.::
Human   247 DRIRCCTHCKDTLLKREQQIDEKEHTPDIVKLYEKLRLCMEKVDQKAPEYIRMAASLNAGETTYS 311

  Fly   309 LADAGALRGKIGQVAEAMDMRSKRILAIFCE----PGSREEALKKAIRLGCIQAIKERMLSLPPL 369
            |..|..||.::.:|.|.:|..||:||.:...    |......|::.||......::|::|.|..|
Human   312 LEHASDLRVEVQKVYELIDALSKKILTLGLNQDPPPHPSNLRLQRMIRYSATLFVQEKLLGLMSL 376

  Fly   370 PEESHIRQMQERRRMETEQRILTEQRMAMEAYER-----NNMAANQSNVGVPGPESGSFAQG-SD 428
            |.:....:::::|:.|.|::...|::.|:|:..|     :.:|:..:|     .|..|..:| :.
Human   377 PTKEQFEELKKKRKEEMERKRAVERQAALESQRRLEERQSGLASRAAN-----GEVASLRRGPAP 436

  Fly   429 LQSLNNW---SAPQAASKSSLDDPLIEQINIIKGYIKQARQDMNFEVVETLELNLRELQREVYER 490
            |:....|   |..|..|:.|  |||::||:.|..:|:||:.....:.|.||:.|||:||.| |::
Human   437 LRKAEGWLPLSGGQGQSEDS--DPLLQQIHNITSFIRQAKAAGRMDEVRTLQENLRQLQDE-YDQ 498

  Fly   491 QR 492
            |:
Human   499 QQ 500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rbsn-5NP_609186.1 FYVE_RBNS5 174..259 CDD:277256 35/110 (32%)
Rbsn 452..490 CDD:463283 16/37 (43%)
RBSNNP_071735.2 Necessary for the correct targeting to endosomes 100..263 53/162 (33%)
FYVE_RBNS5 151..262 CDD:277256 35/110 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..241 4/33 (12%)
Necessary for interaction with EHD1. /evidence=ECO:0000269|PubMed:15020713 264..784 70/245 (29%)
Necessary for interaction with RAB4A 264..500 69/243 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 390..429 9/43 (21%)
COG4913 <398..>523 CDD:443941 35/111 (32%)
Rbsn 461..499 CDD:463283 16/38 (42%)
NPF 548..727 CDD:406900
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..732
Necessary for interaction with RAB5A 627..784
Rbsn 741..779 CDD:463283
Blue background indicates that the domain is not in the aligned region.

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