Protein Alignment Rbsn-5 and FGD4

DIOPT Version :10

• Sequence 1: NP_609186.1
• Gene: Rbsn-5 / 34110
• FlyBaseID: FBgn0261064
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: XP_047284247.1
• Gene: FGD4 / 121512
• HGNCID: 19125
• Length: 922
• Species: Homo sapiens
• Alignment Length: 286
• Identity: 63/286 - (22%)
• Similarity: 103/286 - (36%)
• Gaps: 102/286 - (35%)

  Fly    51 DALKSFKDIFTKAK------------KKILNPFE---DEKGASVSSPA------GSSSSAAGKNP 94
            ||.||.:.|.|.|.            ||:|..:|   :|:  .:.:|:      |.....|.:|
Human   531 DAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEE--DIVNPSNELIKEGQILKLAARN- 592

  Fly    95 NGNGDRNGPSNARSR-LNVFNYM----------------ARQQPG------AECSHFEY---FQ- 132
                     ::|:.| |.:||.|                .|.:.|      .|..:.||   ||
Human   593 ---------TSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQV 648

  Fly   133 SIRNPRLERYAS-------------ETNKLIIRLHRLLKDLPA------DSVQRRQHEQQTVAWL 178
            |.:...||..||             ||.....:.|...::..|      ..|...:..::...|:
Human   649 SGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWI 713

  Fly   179 DGSSVKLCPSCAKSFH-IARRQHHCRLCGGIMCNDCSKF-LPLE-DAMQLASLSTTRSEPLQQLH 240
            ..:.|.:|..|.:.|: :.||:||||.||.::|..||.: ..|| |..:|:
Human   714 RDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLS-------------- 764

  Fly   241 QHENAIRLCEHCLWLLDTRKDMHESR 266
                  ::|:.|..::....|..|.:
Human   765 ------KVCKDCYQIISGFTDSEEKK 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbsn-5	NP_609186.1	FYVE_RBNS5	174..259	CDD:277256	22/87 (25%)
		Rbsn	452..490	CDD:463283
FGD4	XP_047284247.1	RhoGEF	363..547	CDD:238091	7/15 (47%)
		PH1_FDG4	579..672	CDD:275434	21/102 (21%)
		FYVE_FGD1_2_4	710..774	CDD:277280	22/83 (27%)
		PH2_FGD1-4	793..895	CDD:270056