Protein Alignment Tg and Epb42

DIOPT Version :10

• Sequence 1: NP_609174.1
• Gene: Tg / 34093
• FlyBaseID: FBgn0031975
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_038541.1
• Gene: Epb42 / 13828
• MGIID: 95402
• Length: 691
• Species: Mus musculus
• Alignment Length: 713
• Identity: 194/713 - (27%)
• Similarity: 324/713 - (45%)
• Gaps: 59/713 - (8%)

  Fly    54 LGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVA-- 116
            |.:...|....:|:|||:|.    |.:.:.|.:|||:.|.:.::|.   :|:...:|.:..||
Mouse     5 LSIKSCDFHAAENNEEHYTK----AISSQHLTLRRGQSFTITLNFR---APTHTFLSALKKVALI 62

  Fly   117 --DDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDT 179
              ...:||..:.| .|:.|   |..|||...|.|.:|..:.|..||.:..|....:..:.|.:..
Mouse    63 AQTGEQPSKINKT-QAIFP---ISSLGDQKGWSAAVEERDAQHWTVSVTTPVDAVIGHYSLLLQV 123

  Fly   180 KLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQ 244
                .|.:.|||. ...:|||||..||.|:|::..:|.|||::....|:.|:.:.::...|..||
Mouse   124 ----SGKKQYPLG-QFTLLFNPWNRDDAVFLQNEAERTEYVLNQNGFIYLGTADCIQEEPWDFGQ 183

  Fly   245 FERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAPTKWT 309
            ||:.|::.|||:|....::..  ...|..|||.:.||::::....||..:.::....|....|..
Mouse   184 FEKDVMDLSLKLLSMDKQVKD--WNQPAHVARVVGALLHALKKKSVLPISQTQAAQEGALLYKRR 246

  Fly   310 GSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFIDAN 373
            |||.||:|:...| ::|...|.|..:.|..|:.|.||||:|::|.:.||..|..||.||.:.:..
Mouse   247 GSVPILRQWLTGQGRAVYETQAWVSAAVACTVLRCLGIPARVVTTFDSAQGTVGSLLVDEYYNEE 311

  Fly   374 NKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVAAVK 438
            ..:........||.:....|.||.||||..|    :.|||::.......:..:.......|.|||
Mouse   312 GLQNGEGQRGHIWVFQTSVECWMNRPDLSQG----YGGWQILHPRAPNGAGVLGSCSLVPVRAVK 372

  Fly   439 NGDILRPFDGGFVFAEVNADKLYWR--YNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDITDT 501
            .|::........:||.|||..:.|:  .:|..:.....|||   :|:.||||.|.....||||..
Mouse   373 EGELQLDPAVPELFAAVNASCVVWKCCEDGKLELTNSNRKD---VGNCISTKVVGSDRCEDITQN 434

  Fly   502 YKHAERSEEERSTMLKALKQSRHAFSRYYL-NDN---------FNDIEFDMELKDDIKI---GQS 553
            ||:...|.:|:..:.|..|:      |..| .||         ::.:....|....|.:   ||
Mouse   435 YKYPAGSLQEKEVLEKVQKE------RLKLGKDNGMCPPSCEPWDPLHMFFEASSSIPLSGDGQ- 492

  Fly   554 FSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYD 618
            .||.|......|.:.|:..|   ..|:.|.||.|..:.:......|:|.....:...:.|..:..
Mouse   493 LSVTLINPTDEEKKVHLVIG---AQALYYNGVLAAGLWSKKQLFMLKPNQVMRLSTNLSFSCFEQ 554

  Fly   619 KLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQ-KELDVILRLENPLPIP 682
            .....:..:::|.|:...|....:||::..:.|||:..::.:.|  || :.|.|.:|:.|.|..|
Mouse   555 TPPENSFLRVTAMARYSHTSLSCFAQENMAIGKPDLIIEMPKRA--AQYRPLTVSVRMHNSLEAP 617

  Fly   683 LHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVDGYR 744
            :...:.::.|.| |.:..::.:..:..|.:....|::||.:.|...:..:.......::.|||
Mouse   618 MQNCIISIFGRGLIHREKRYGLGSLWPGSSLHTQFQFTPTHLGLQRLTVEVDCDMFQNLTGYR 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	58..180	CDD:459971	34/125 (27%)
		TGc	324..419	CDD:214673	32/94 (34%)
		Transglut_C	538..644	CDD:460002	21/108 (19%)
		Transglut_C	652..750	CDD:460002	22/95 (23%)
Epb42	NP_038541.1	Transglut_N	8..124	CDD:459971	34/130 (26%)
		Band 3 binding. /evidence=ECO:0000250	31..39		4/7 (57%)
		TGc	261..351	CDD:214673	32/93 (34%)
		Transglut_C	475..573	CDD:460002	20/101 (20%)
		Transglut_C	588..686	CDD:460002	22/95 (23%)