Protein Alignment Tg and tgm5

DIOPT Version :10

• Sequence 1: NP_609174.1
• Gene: Tg / 34093
• FlyBaseID: FBgn0031975
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_031750630.1
• Gene: tgm5 / 100486682
• XenbaseID: XB-GENE-986930
• Length: 726
• Species: Xenopus tropicalis
• Alignment Length: 743
• Identity: 230/743 - (30%)
• Similarity: 373/743 - (50%)
• Gaps: 77/743 - (10%)

  Fly    60 DLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHF-NRDYSPSKDAISFIFTVADDTKPSP 123
            |..::.|::.|||..    .....|.:|||:||.:.:|| .|.:.|.:|.:  ||.|.....|..
 Frog     9 DFQIKRNNKAHHTDE----TGDRRLFIRRGQPFFITVHFKTRGFQPGQDNV--IFLVETGPWPDE 67

  Fly   124 GHGTLNALVPHDGIDYLGDTLE---WGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTKLLGDG 185
            ..|| .|:.|      |...|.   |.|.:|::...::.:.:..|.|..:.:::|.:.   :..|
 Frog    68 SSGT-KAIFP------LSKALNKTMWSATLENNGANSMVLAMLSPHTAIIGQYQLKMQ---ISSG 122

  Fly   186 SRSYPLPLPIYV-LFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQFERHV 249
            :::....|..:| ||||||.||.|::.:..:|:|||::|...:::|::|.:.|..|..||||..:
 Frog   123 TKTTNYNLGTFVLLFNPWCADDDVFMGNEAERQEYVINDYGFVYQGNHNWIIPCAWNFGQFEDDI 187

  Fly   250 LECSLKVLG-TVGRIPPAY-----RGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAPTKW 308
            ::.|||:|. .:..|..::     |.:||.::|.:.|::||.||:|||.||||.|::.||:|:.|
 Frog   188 VDISLKILDKNLNYIQDSFKDLKNRNNPVYISRVICAMINSNDDNGVLQGNWSGDYTNGVSPSAW 252

  Fly   309 TGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFIDA 372
            .||:.||:|:||:. :.||:.|||.|:.|:.|:.|.||||:|::|.:.|||||..:|.:|.:.|.
 Frog   253 NGSILILRQWYKSDCQPVKYGQCWVFAAVMCTVMRCLGIPARVVTNFDSAHDTDQNLLIDEYYDT 317

  Fly   373 NNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVAAV 437
            ..|||..||.|||||:|||.|.||.|.||..|    :.||||:|.||||||:.::..|||||.|:
 Frog   318 TGKKLSKETKDSIWNFHVWCECWMARRDLPPG----YGGWQVLDPTPQEASNGIFVCGPASVKAI 378

  Fly   438 KNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDITDTY 502
            :.|||...:|..||||.||||.:.|..:  ::..:....|...:|..||||.....||||:|..|
 Frog   379 REGDIHLNYDAPFVFAMVNADCVSWIVS--TKGKEKYHCDPHLVGTQISTKRAGSDEREDLTHQY 441

  Fly   503 KHAERSEEERSTMLKA------------LKQSRH-----------------AFSRY---YLNDNF 535
            |:.|.:.|||....||            :.:|.|                 ..|||   ..|.|.
 Frog   442 KYEEETAEERKAFEKAISRLHKGGAIPNINESEHMNGANGTSANGITPSPDESSRYTPQNENSNL 506

  Fly   536 ND------IEFDMELKDDIKIGQSFSVVLKVSNK-SESRTHMATGQISCDAVLYTGVGAVEVKTL 593
            |.      :....:|.:..::|::.|:||...|. |.::|...:  :|..|:.:.|..|.:....
 Frog   507 NSPLREALLLLKFKLTESPQLGETISLVLLAGNMVSTAKTLKLS--LSAQAMKHDGKPAQQFWRD 569

  Fly   594 GFELELEPKSSDYVRMEVIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQL 658
            ...:||.|....::..::.:.:|...|......:..|..:...|......:.|..:..|.:....
 Frog   570 SMYVELGPHEEKWLLFKIPYAKYGPSLEDNHLIRFIAVGEQNITWEKVLVEKDVNLALPAVVINF 634

  Fly   659 GEAAIVAQKELDVILRLENPLPIPLHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPY 722
            .|.|:| .|.....|...||:...:|.....::|.| :::.:|..:..:..|..|...|::.|..
 Frog   635 LELAVV-DKTCKAELSFSNPINEAIHDCQILIQGSGLLKKQVKLNMGTMKPGQKAVVAFEFVPWK 698

  Fly   723 AGRGTMLAKFTSKELDDVDGYRHYEIEP 750
            .|...:....:|.....:.|::...::|
 Frog   699 VGYKQLQVNISSNRFKGLKGFKSVVVKP 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	58..180	CDD:459971	32/123 (26%)
		TGc	324..419	CDD:214673	48/94 (51%)
		Transglut_C	538..644	CDD:460002	19/106 (18%)
		Transglut_C	652..750	CDD:460002	19/98 (19%)
tgm5	XP_031750630.1	Transglut_N	9..120	CDD:459971	32/126 (25%)
		TGc	267..360	CDD:214673	48/96 (50%)
		Transglut_C	517..621	CDD:460002	19/105 (18%)
		Transglut_C	628..726	CDD:460002	19/98 (19%)