Protein Alignment Wwox and CBR1

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_001748.1
• Gene: CBR1 / 873
• HGNCID: 1548
• Length: 277
• Species: Homo sapiens
• Alignment Length: 279
• Identity: 58/279 - (20%)
• Similarity: 112/279 - (40%)
• Gaps: 75/279 - (26%)

  Fly   124 ALITGANCGIGYETARSLAH-HGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLSSLR 187
            ||:||.|.|||....|.|.. ...:::...|:.:..:||::::..|..:.    ||..||:..|:
Human     8 ALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSP----RFHQLDIDDLQ 68

  Fly   188 SVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQ--LETLF---- 246
            |::...:.:::....:|.|:.|||:              .|:|:..:.|::..:  ::|.|
Human    69 SIRALRDFLRKEYGGLDVLVNNAGI--------------AFKVADPTPFHIQAEVTMKTNFFGTR 119

  Fly   247 DYKTRIIVLSSESHRFANLP--VENLAVHHLSPP-PEKY-------------------------- 282
            |..|.::.|.....|..|:.  :...|:...||. .:|:
Human   120 DVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVH 184

  Fly   283 ----WSMMAYNNAKL----CNVLFAQELAQRWKQRGISVFSLHPGNMVSSDLSRNYWFYRLLFAI 339
                |...||...|:    .:.:.|::|:::.|...|.:.:..|| .|.:|::.
Human   185 QKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPG-WVRTDMAG----------- 237

  Fly   340 VRPFTKSLQQAAATSIYCA 358
             ...|||.::.|.|.:|.|
Human   238 -PKATKSPEEGAETPVYLA 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	58/279 (21%)
CBR1	NP_001748.1	carb_red_PTCR-like_SDR_c	6..277	CDD:187585	58/279 (21%)