Protein Alignment Wwox and Wwox

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_062519.2
• Gene: Wwox / 80707
• MGIID: 1931237
• Length: 414
• Species: Mus musculus
• Alignment Length: 406
• Identity: 207/406 - (50%)
• Similarity: 271/406 - (66%)
• Gaps: 14/406 - (3%)

  Fly     4 LPDTDSEDELPPGWEERATDDGTVCYVNQQGKTSQWTHPRTGRSKRITGELPLGWEKYYDEQGKR 68
            |.|||||||||||||||.|.||.|.|.|...:.:||.||:||:.||:.|:||.|||:..||.|:.
Mouse     9 LDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQV 73

  Fly    69 FM--FLNKETQQRTNVDPRLAFAVEE-PTQNVAQVRQRFDSCSTALQVLHGKDLHGRTALITGAN 130
            |.  .:||.|   |.:||||||.|:: ||:  ...|||:|..:||:::|.|:|..|:..|:||||
Mouse    74 FFVDHINKRT---TYLDPRLAFTVDDNPTK--PTTRQRYDGSTTAMEILQGRDFTGKVVLVTGAN 133

  Fly   131 CGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLSSLRSVQRFVEE 195
            .|||:|||:|.|.||..:|.||||.|.|..|:.||.:|...|:...  ..|||:.|||||.|.|.
Mouse   134 SGIGFETAKSFALHGAHVILACRNLSRASEAVSRILEEWHKAKVEA--MTLDLAVLRSVQHFAEA 196

  Fly   196 IKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQLETLF--DYKTRIIVLSSE 258
            .|.....:..|:.|||.||||:..|.|||||||||:||.||||...|:.:.  ....|:||:|||
Mouse   197 FKAKNVSLHVLVCNAGTFALPWGLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSSPARVIVVSSE 261

  Fly   259 SHRFANLPVEN--LAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGISVFSLHPGNM 321
            ||||.::...:  |.:..||||...||:|:|||.:||||:||:.||.:|...||::..::|||||
Mouse   262 SHRFTDINDSSGKLDLSRLSPPRSDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNM 326

  Fly   322 VSSDLSRNYWFYRLLFAIVRPFTKSLQQAAATSIYCATANELTGLSGLYFNNCFFCEPSKLSKSA 386
            :.|.:.||.|.|:|||.:.||||||:||.|||::|||.|.||.||.|:|||||..|.||:.::|.
Mouse   327 MYSAIHRNSWVYKLLFTLARPFTKSMQQGAATTVYCAVAPELEGLGGMYFNNCCRCLPSEEAQSE 391

  Fly   387 ALQQQLWKLSENLIAE 402
            ...:.||:|||.||.:
Mouse   392 ETARALWELSERLIQD 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736	17/29 (59%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	145/284 (51%)
Wwox	NP_062519.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		13/14 (93%)
		WW	18..47	CDD:459800	16/28 (57%)
		Nuclear localization signal	50..55		2/4 (50%)
		WW	60..90	CDD:238122	13/31 (42%)
		human_WWOX_like_SDR_c-like	124..407	CDD:187669	145/286 (51%)
		Interaction with MAPT. /evidence=ECO:0000269|PubMed:15126504	125..414		145/287 (51%)
		Mediates targeting to the mitochondria	209..273		35/65 (54%)