Protein Alignment Wwox and dhrs12

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_001070025.1
• Gene: dhrs12 / 556393
• ZFINID: ZDB-GENE-060929-1134
• Length: 318
• Species: Danio rerio
• Alignment Length: 306
• Identity: 87/306 - (28%)
• Similarity: 132/306 - (43%)
• Gaps: 46/306 - (15%)

  Fly   119 LHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDL 183
            ::||:.:|||||.|||...|..:|..|..:...|||:..||.|.:.|.::..:.......  :|:
Zfish    38 VNGRSFIITGANSGIGKAAAYEIAKRGGTVHLVCRNKDRAEEARKDIVEQSKSENVHVHL--VDM 100

  Fly   184 SSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQL-ETL-F 246
            ||.|.|..|.....|: .::..||.|||........|.||||..|..:.|..:.||..| .|| .
Zfish   101 SSPRKVWEFASGFSQN-HNLHVLINNAGCMVNQRELTEDGLEKNFATNTLGTYILTTALIPTLKR 164

  Fly   247 DYKTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGI 311
            ....|:|.:||     ..:.|:.|.|..|......:...|||...|...|:..::.|.:.|:  |
Zfish   165 SENPRVITVSS-----GGMLVQKLNVEDLQFEKGSFDGTMAYAQNKRQQVIMTEQWATQHKE--I 222

  Fly   312 SVFSLHPGNMVSSDLSRNYW------------FYRLLFAIVRPFTKSLQQAAATSIYCATANELT 364
            ...|:|||           |            ||..:...:|  |::  |.|.|.::.|.::..:
Zfish   223 HFSSMHPG-----------WADTPAVRSSMPDFYEKMKNKLR--TEA--QGADTVVWLAVSDAAS 272

  Fly   365 GL-SGLYFNNCFFCE---PSKLSKSAALQQQLWKLSENLIAELVEQ 406
            .. |||:|.:.....   |...||:...:.|  || .||:.||.::
Zfish   273 RQPSGLFFQDRKAVSTHLPLAFSKTPPAEDQ--KL-VNLLEELADK 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	85/298 (29%)
dhrs12	NP_001070025.1	Rossmann-fold NAD(P)(+)-binding proteins	40..293	CDD:473865	78/277 (28%)