Protein Alignment Wwox and Rdh14

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_001102746.1
• Gene: Rdh14 / 500629
• RGDID: 1565196
• Length: 334
• Species: Rattus norvegicus
• Alignment Length: 301
• Identity: 114/301 - (37%)
• Similarity: 168/301 - (55%)
• Gaps: 25/301 - (8%)

  Fly   119 LHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQE--------RPAARSR 175
            :||:|.||||||.|:|..||..|...|..:|..||:|:.||.|..::.||        ..|...:
  Rat    42 MHGKTVLITGANSGLGRATAGELLRLGARVIMGCRDRARAEEAAGQLRQELGQAGGLGPDATDGQ 106

  Fly   176 CRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTL 240
            .....|||:|||||:.|.:|:.|....:|.||.|||||..|||:|.||.|..|.|:||.||.||.
  Rat   107 LVVKELDLASLRSVRAFCQELLQEEPRLDVLINNAGVFQCPYTKTEDGFEMQFGVNHLGHFLLTN 171

  Fly   241 QLETLF--DYKTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELA 303
            .|..|.  ...:||:|:||:.:::.::..|:|      ...:.|.....|:.:||.|:||.:|||
  Rat   172 LLLGLLKSSAPSRIVVVSSKLYKYGDINFEDL------NSEQSYNKSFCYSRSKLANILFTRELA 230

  Fly   304 QRWKQRGISVFSLHPGNMVSSDLSRNY---WFYRLLFAIVR-PFTKSLQQAAATSIYCATANELT 364
            .|.:...::|..|||| :|.::|.|:.   ...|.||.:|. .|.|:..:.|.||||.|::.::.
  Rat   231 HRLEGTNVTVNVLHPG-IVRTNLGRHIHIPLLARPLFNLVSWAFFKTPLEGAQTSIYLASSPDVE 294

  Fly   365 GLSGLYFNNCFFCE--PSKLSKSAALQQQLWKLSENLIAEL 403
            |:||.||.:|...|  |..:.:|.|  ::||.:||.::..|
  Rat   295 GVSGRYFGDCKEEELLPKAMDESVA--RKLWDISEVMVGIL 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	112/296 (38%)
Rdh14	NP_001102746.1	Rossmann-fold NAD(P)(+)-binding proteins	44..326	CDD:473865	110/290 (38%)