Protein Alignment Wwox and rdh12l

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_001009912.2
• Gene: rdh12l / 494176
• ZFINID: ZDB-GENE-040801-48
• Length: 297
• Species: Danio rerio
• Alignment Length: 310
• Identity: 118/310 - (38%)
• Similarity: 169/310 - (54%)
• Gaps: 38/310 - (12%)

  Fly   100 VRQRFDSCSTALQVLHGKDLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIER 164
            :|..|.|.|:|.:      |.|:|.||||||.|||.|||..||..|..||.|||:...||||::.
Zfish     4 MRNMFCSWSSAAR------LDGKTVLITGANTGIGKETAIDLAKRGARIIMACRDMEKAEAALKE 62

  Fly   165 IAQERPAARSRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQ 229
            :...  :.......::||||..:|::.|.|:|.:....::.||.||||...||.:|.||.|....
Zfish    63 VKDS--SGNQDVFISSLDLSDSKSIRGFAEKINKEEKQVNILINNAGVMVCPYGKTADGFEMQIG 125

  Fly   230 VSHLSHFYLTLQLETLF--DYKTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAK 292
            |:|:.||.||..|..|.  ....|||.:||.:|::..:.:|::      ...:.|....||..:|
Zfish   126 VNHMGHFLLTYLLLDLIKRSAPARIINVSSTAHQWGTINLEDI------NSEKNYDKQKAYCQSK 184

  Fly   293 LCNVLFAQELAQRWKQRGISVFSLHPGNMVSSDLSRN--------YWFYRLLFAIVRPFTKSLQQ 349
            |.||||.:.||:|.:..|::.:||||| :|.:||.|:        .||       .:||||:..|
Zfish   185 LANVLFTRSLAKRLEGTGVTAYSLHPG-VVQTDLWRHLSKPQQAVMWF-------TKPFTKTSVQ 241

  Fly   350 AAATSIYCATANELTGLSGLYFNNCFFCEPSKLSKSA---ALQQQLWKLS 396
            .|.||||||...||...||.|:::   |.|:|.:|:|   .:.|:||:||
Zfish   242 GAQTSIYCAVDPELQTESGKYYSD---CAPAKAAKAAMDDEVAQRLWELS 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	112/289 (39%)
rdh12l	NP_001009912.2	Rossmann-fold NAD(P)(+)-binding proteins	19..288	CDD:473865	110/287 (38%)