Protein Alignment Wwox and CG8888

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_610724.1
• Gene: CG8888 / 36293
• FlyBaseID: FBgn0033679
• Length: 388
• Species: Drosophila melanogaster
• Alignment Length: 282
• Identity: 53/282 - (18%)
• Similarity: 91/282 - (32%)
• Gaps: 95/282 - (33%)

  Fly   121 GRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLSS 185
            |:..||||....:.:..|:.|...|. .::|..|....|:...:|.:|  ....|.:...||::|
  Fly    95 GKGVLITGCEAPLAWYLAKKLDDLGF-TVYAGFNTPIEESDEAKILKE--VTSGRMKLLHLDVTS 156

  Fly   186 LRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQLETL----- 245
            .:::......:.|.:.|                    |.|..:.|.|.:|:....:||.:
  Fly   157 EKTILEAARYVSQHLPH--------------------GAEGLWSVVHCAHWIALGELEWIPFAVL 201

  Fly   246 ---FDYKT-------------------RIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAY 288
               .|...                   |::.|:|..:|..: ||..:              ..|.
  Fly   202 RKSLDLNLLGSARLTQIFLPLVRRAHGRVVFLTSGLNRVPS-PVRGI--------------QCAT 251

  Fly   289 NNAKLCNVLFAQELAQRWKQRGISVFSLHPG----------------------NMVSSDLSRNYW 331
            ..|..|   ||..|.|..:.||:.|..:..|                      |.:||:..:.|.
  Fly   252 QAAVDC---FAACLRQEMRTRGVDVSVVAAGEFAPGNGWLNETELRDQAKQMWNQLSSEQKKTYG 313

  Fly   332 --FYRLLFAIVRPFTKSLQQAA 351
              :|......|..:::   |||
  Fly   314 EDYYEAAMTSVEKYSR---QAA 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	53/282 (19%)
CG8888	NP_610724.1	Rossmann-fold NAD(P)(+)-binding proteins	96..380	CDD:473865	52/281 (19%)