Protein Alignment Wwox and E04F6.15

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_495501.1
• Gene: E04F6.15 / 184041
• WormBaseID: WBGene00017131
• Length: 319
• Species: Caenorhabditis elegans
• Alignment Length: 316
• Identity: 109/316 - (34%)
• Similarity: 177/316 - (56%)
• Gaps: 16/316 - (5%)

  Fly   101 RQRFDSCSTALQVLHGKDLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERI 165
            :::|.|.:.||:||.|.||.|:|..|||...|||.|||::|...|..::...||.:::||:.:.:
 Worm     8 KRQFHSRTNALEVLDGIDLSGKTFAITGTTSGIGVETAKALILKGAHVVMINRNYTASEASKKSL 72

  Fly   166 AQERPAAR---SRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETT 227
            ..|.|.|:   .:|     ||:||.||::..:|..:....:..||||||||......|.||.|..
 Worm    73 LIETPNAQIDIVQC-----DLNSLSSVKKAADEYLEQKWPLHGLILNAGVFGPSEKTTSDGFEAH 132

  Fly   228 FQVSHLSHFYLTLQLETLF--DYKTRIIVLSSESHRFANLPVENLAVHHLS---PPPEKYWSMMA 287
            |.::||:||.|..:|..:.  ...:||::::|...:...:..::..|..|.   |.....|....
 Worm   133 FGINHLAHFILIKELLPVLRESAPSRIVIVTSMLSKHTCVKPDSRIVEKLDTLCPKEATQWYFRL 197

  Fly   288 YNNAKLCNVLFAQELAQRWKQRGISVFSLHPGNMVSSDLSRNYWFYRLLFAIVRPFTKSLQQAAA 352
            |..:|:||:|.|.:|.:...:..|||:::|||:.|.:||.|::..:.:...:..||||:..|.||
 Worm   198 YAKSKMCNILTAFKLHRDEFKNRISVYAVHPGSGVRTDLHRDFGLWSIADFLSIPFTKNASQGAA 262

  Fly   353 TSIYCATANELTGLSGLYFNNCFFCEPS---KLSKSAALQQQLWKLSENLIAELVE 405
            ||:|||...|:..|||.|:.:|:..|.:   |:|:...||:.||:.||.||.:.::
 Worm   263 TSLYCAVHPEVKELSGKYWESCWDDEKNLDKKVSRDEELQEALWEHSEKLIMKYLD 318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	100/291 (34%)
E04F6.15	NP_495501.1	retinol-DH_like_SDR_c_like	28..306	CDD:212492	94/282 (33%)