Protein Alignment Wwox and dhs-8

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_001022250.1
• Gene: dhs-8 / 175108
• WormBaseID: WBGene00000972
• Length: 379
• Species: Caenorhabditis elegans
• Alignment Length: 348
• Identity: 110/348 - (31%)
• Similarity: 176/348 - (50%)
• Gaps: 41/348 - (11%)

  Fly    66 GKRFMFLNKETQQRTNVDPRLAFAVEEPTQNVAQVRQRFDSCSTALQVLHGKDLHGRTALITGAN 130
            |..|:.|:|....:.|                 :|| .|.|.:.|.:||.|.|:.|:|..|||..
 Worm    48 GLLFLQLSKTKMSQAN-----------------RVR-LFHSRTHAFEVLKGIDVSGKTFAITGTT 94

  Fly   131 CGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLSSLRSVQRFVEE 195
            .|||..||..||..|..::...||...:|...:||.:::|:|:....|.  |||.|::|::..|:
 Worm    95 SGIGINTAEVLALAGAHVVLMNRNLHESENQKKRILEKKPSAKVDIIFC--DLSDLKTVRKAGED 157

  Fly   196 IKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQLETLF-----DYKTRIIVL 255
            .......|..||||||||.....:|.||.|:.:.|:.::||.|   |..|.     ...:|::.|
 Worm   158 YLAKNWPIHGLILNAGVFRPAAAKTKDGFESHYGVNVVAHFTL---LRILLPVVRRSAPSRVVFL 219

  Fly   256 S---SESHRF-ANLPV-ENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGISVFS 315
            |   |..|.| .::.: |.:::  |........::..|..:|:.::|.|.:|.:...:.|||.:|
 Worm   220 SSTLSSKHGFKKSMGISEKMSI--LQGEDSSASTLQMYGASKMADMLIAFKLHRDEYKNGISTYS 282

  Fly   316 LHPGNMVSSDLSRNYWFYRLLFAIVRPFTKSLQQAAATSIYCATANELTGLSGLYFNNCFFCEPS 380
            :|||:.|.:|:.||....:.:..:..||||:..|.|||::||||..|:..:||.|:.:|:  :..
 Worm   283 VHPGSGVRTDIFRNSLLGKFIGFVTTPFTKNASQGAATTVYCATHPEVEKISGKYWESCW--DND 345

  Fly   381 KLSKSAA----LQQQLWKLSENL 399
            |:.|..|    ||:.|||..|.:
 Worm   346 KIDKKTARDEELQEALWKKLEQI 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	96/293 (33%)
dhs-8	NP_001022250.1	Rossmann-fold NAD(P)(+)-binding proteins	85..362	CDD:473865	92/285 (32%)