Protein Alignment Wwox and Rdh11

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_067532.2
• Gene: Rdh11 / 17252
• MGIID: 102581
• Length: 316
• Species: Mus musculus
• Alignment Length: 312
• Identity: 112/312 - (35%)
• Similarity: 170/312 - (54%)
• Gaps: 31/312 - (9%)

  Fly    99 QVRQRFDS--CSTALQVLHGKDLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAA 161
            ::|:...|  |::.:|      |.|:.|::||||.|||.|||:.||..|..:..|||:....|.|
Mouse    20 KIRKMLSSGVCTSNVQ------LPGKVAIVTGANTGIGKETAKDLAQRGARVYLACRDVDKGELA 78

  Fly   162 IERIAQERPAARSRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLET 226
            ...|  :.....|:.....|||:..:|::.|.::......|:..||.||||...||::|.||.|.
Mouse    79 AREI--QAVTGNSQVFVRKLDLADTKSIRAFAKDFLAEEKHLHLLINNAGVMMCPYSKTADGFEM 141

  Fly   227 TFQVSHLSHFYLT-LQLETLFD-YKTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSM-MAY 288
            ...|:||.||.|| |.||.|.: ..:||:.|||..|....:...||       ..||::|. :||
Mouse   142 HIGVNHLGHFLLTHLLLEKLKESAPSRIVNLSSLGHHLGRIHFHNL-------QGEKFYSAGLAY 199

  Fly   289 NNAKLCNVLFAQELAQRWKQRGISVFSLHPGNMVSSDLSRNY-----WFYRLLFAIVRPFTKSLQ 348
            .::||.|:||.:|||:|.|..|::.:|:|||. |.|:|:| |     |.::|.|.    |.|:.|
Mouse   200 CHSKLANILFTKELAKRLKGSGVTTYSVHPGT-VHSELTR-YSSIMRWLWQLFFV----FIKTPQ 258

  Fly   349 QAAATSIYCATANELTGLSGLYFNNCFFCEPSKLSKSAALQQQLWKLSENLI 400
            :.|.||:|||....|..|||.:|::|.....|...::..:.::||.:|.:|:
Mouse   259 EGAQTSLYCALTEGLESLSGSHFSDCQLAWVSYQGRNEIIARRLWDVSCDLL 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	107/288 (37%)
Rdh11	NP_067532.2	Rossmann-fold NAD(P)(+)-binding proteins	38..306	CDD:473865	105/282 (37%)