Protein Alignment Wwox and DHRS13

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_653284.2
• Gene: DHRS13 / 147015
• HGNCID: 28326
• Length: 377
• Species: Homo sapiens
• Alignment Length: 297
• Identity: 102/297 - (34%)
• Similarity: 150/297 - (50%)
• Gaps: 34/297 - (11%)

  Fly   118 DLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALD 182
            :|.||||::||||.|||..||..||..|..::.|||::...|||...:.||  :..:...|.|||
Human    33 NLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQE--SGNNEVIFMALD 95

  Fly   183 LSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLT-LQLETLF 246
            |:||.||:.|......|...:|.||.|||:.:...||  :......:|:|:..|.|| |.|..|
Human    96 LASLASVRAFATAFLSSEPRLDILIHNAGISSCGRTR--EAFNLLLRVNHIGPFLLTHLLLPCL- 157

  Fly   247 DYK----TRIIVLSSESHRFANLPVENLAVHHLSPPPEKYW--SMMAYNNAKLCNVLFAQELAQR 305
              |    :|::|::|.:|....|..:.|      ..|...|  .:.||.:.||.|||||:|||.:
Human   158 --KACAPSRVVVVASAAHCRGRLDFKRL------DRPVVGWRQELRAYADTKLANVLFARELANQ 214

  Fly   306 WKQRGISVFSLHPGNMVSSDLSRNYWFYRLLFAIVRPFTKSL--------QQAAATSIYCATANE 362
            .:..|::.::.||| .|:|:|     |.|.:...:||..:.|        :..|.|.:|||....
Human   215 LEATGVTCYAAHPG-PVNSEL-----FLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEG 273

  Fly   363 LTGLSGLYFNNCFFCEPSKLSKSAALQQQLWKLSENL 399
            :..|||.||.||...|....::......:||:.|:.|
Human   274 IEPLSGRYFANCHVEEVPPAARDDRAAHRLWEASKRL 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	101/294 (34%)
DHRS13	NP_653284.2	retinol-DH_like_SDR_c_like	36..304	CDD:212492	97/286 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..377		1/2 (50%)