Protein Alignment Wwox and si:dkey-73n8.3

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_001186991.1
• Gene: si:dkey-73n8.3 / 100150965
• ZFINID: ZDB-GENE-141219-27
• Length: 296
• Species: Danio rerio
• Alignment Length: 288
• Identity: 103/288 - (35%)
• Similarity: 160/288 - (55%)
• Gaps: 20/288 - (6%)

  Fly   119 LHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDL 183
            |.|:||::||||.|||.|||:.||:.|..:|.|||:...||.|...|:::...|....|  .|||
Zfish    18 LDGKTAIVTGANTGIGKETAKDLANRGARVILACRDLVKAEQAASDISRDVENANVVVR--KLDL 80

  Fly   184 SSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQLETLFDY 248
            :..:|:..|.|.|..:...:..||.||||...||:.||||.||.|.|:||.||:||..|..|..:
Zfish    81 ADTKSICEFAELIYNTEKSLHLLINNAGVAICPYSTTVDGFETQFGVNHLGHFFLTFLLIDLLKH 145

  Fly   249 K--TRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGI 311
            .  :|:|.:||..|....:..|:|      ...:.|..:.||..:||.|:||.:|||.|.::.|:
Zfish   146 SAPSRVINVSSLVHPMGKIHFEDL------NSEKNYHPVKAYVQSKLANILFTRELASRVEELGV 204

  Fly   312 SVFSLHPGNMVSSDLSRNYW----FYRLLFAIVRPFTKSLQQAAATSIYCATANELTGLSGLYFN 372
            .|:::.|| :|::|::|:..    |:...|..:   .|:..:.|.|::|||...:|.  :|.|::
Zfish   205 RVYAVDPG-LVNTDITRHLMKPVQFFVKTFGFM---IKTPAEGAYTTLYCALTPDLP--TGSYYS 263

  Fly   373 NCFFCEPSKLSKSAALQQQLWKLSENLI 400
            ||.....|:.:|......:||.:|.:|:
Zfish   264 NCAVASCSRAAKDDNSASKLWAVSCHLL 291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	102/286 (36%)
si:dkey-73n8.3	NP_001186991.1	Rossmann-fold NAD(P)(+)-binding proteins	20..287	CDD:473865	100/280 (36%)