DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and lama1

DIOPT Version :10

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_001030158.1 Gene:lama1 / 569971 ZFINID:ZDB-GENE-060118-1 Length:3075 Species:Danio rerio


Alignment Length:2161 Identity:521/2161 - (24%)
Similarity:793/2161 - (36%) Gaps:655/2161 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLELRLIVVIVLALLSWQWDPVDSQRPPQHGRRDRPKYPPNKFIKTHPCERSSCYPATGNLLIGR 65
            |:|:|:.::.:|||:......|::|   |.|                      .:||..||....
Zfish     1 MMEMRMKMLWLLALVFSSVICVEAQ---QRG----------------------LFPAILNLASNA 40

  Fly    66 ENRLTASSTCGLHSPERFC-ILSH-----LQDKKCFLCDTREETKHDPYKNHRIGQIIYKTKPGT 124
            |  ::.::|||...||.|| ::.|     :::.:|.:||...:   :|.:.|.|...|    .||
Zfish    41 E--ISTNATCGDPDPEMFCKLVEHVPGRRIRNPQCRICDANSQ---NPKEQHPITNAI----DGT 96

  Fly   125 NIPTWWQS---ENGKEN--ATIQLDLEAEFHFTHLII-TFTTFRPAAMYIERSFD---FGQTWHI 180
            |:  ||||   :||::.  .|:.|||...|...::|| ...:.||....:|||.|   | |.|..
Zfish    97 NL--WWQSPSIKNGRQFHWVTVTLDLRQVFQVAYIIIKAANSPRPGNWILERSLDGVNF-QPWQF 158

  Fly   181 YRYFAYDCKESF---PGV-PTVLENITDVMCTSRYSNVEPSRNGEV---IFRVLPPNINVTDPYA 238
            |.....:|...:   |.: |...:...:|:|||.||.:.|..:||:   :....|...::|....
Zfish   159 YAISDTECLTRYNITPRIGPPTYKRDDEVICTSYYSRLVPLEHGEIHTSLINGRPSADDLTPELL 223

  Fly   239 EHVQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEE--------KYYYGISNMVVRGSCSCYGHAS 295
            |....:.    :|:::.::..|..:|:.....:.:        :|||.|.::.|.|.|.|||||.
Zfish   224 EFTSARF----IRLRLQRIRTLNADLMTLSYRDPKDVDPIVTRRYYYSIKDISVGGMCICYGHAQ 284

  Fly   296 QCLPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDH 360
            .| |.||...:.         :|.|.|||.|.:|.||...::..||:|......|.|:||.|::.
Zfish   285 SC-PWDPVTKKL---------QCVCEHNTCGESCNECCPGYHQEPWQPGTLSDGNTCEKCNCHNK 339

  Fly   361 AVSCHFDEAVF-------TASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPC 418
            |..|.:::.|.       |...|..||||.||.|||.|.:||.|...:||..:....:|..|..|
Zfish   340 ADDCFYNQTVADLKLSMNTHGQFTGGGVCVNCRHNTAGVNCETCADGYYRPHQVSPYAEEPCVEC 404

  Fly   419 DCDPQGSSDDGIC---DSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTC 480
            .||.:||... :|   |:....:.|...|.|.||....|.:|::|..|:    .|.|. |..|.|
Zfish   405 QCDMRGSVSP-VCIRDDNHANPDAGLSPGQCVCKEGFAGEKCDRCAFGF----RDFPV-CSRCEC 463

  Fly   481 NPLGTLNNSGCVMRTGECKCKKYVTGKDCNQCMPETYGLSES-PEGCSLCNCDAGGSYDNYCDVI 544
            |..|:.|...|:    ||.||..|.|..|:.|....|.|..| ||||:.|          :|..:
Zfish   464 NLDGSHNTDPCM----ECVCKANVMGSHCDLCKQGFYNLQASNPEGCTEC----------FCFGV 514

  Fly   545 SGQCRC----------------RPHMTGRSCSQPKQNYFIPLLPEVHEAEVVDECISYGANGNCS 593
            |..|..                |.|.|..|...|                |.||        |..
Zfish   515 SDVCESSTWFSSSVVHRDGVLHRLHQTSISFWSP----------------VSDE--------NLI 555

  Fly   594 LVAETPDGSFTGIGFTRVPE---NSELVFTVGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPD 655
            :...:.|...:.:.....||   |::|......:..|:.||       ||.   ||...||....
Zfish   556 ISNRSTDADPSSVWTWAAPEPFLNNKLTSYGSFLNYSVAYD-------TSE---ENVDKTLRSHF 610

  Fly   656 QVDPEGGCGELAAATSSETRIPFSLPDRSRQVV-ALNEVCLEAGKVYKFRIYFERKRHDVDSPTA 719
            .|..||....|..|.|:  |:..:.....|..| .|.::.:::          ...|........
Zfish   611 SVIIEGNGRTLRQAQSA--RLLLNAHTHQRVFVQMLPQIFIDS----------HSGRSVQRDELM 663

  Fly   720 TILVDSLTLIPRIDVTPIFQGSVLADIRKKDYEKYNCKSSLYDMNYKSDPKCQNLDNILSVFVHD 784
            |:|.|...|..|.::....:|::                              .|.:: |:.|.|
Zfish   664 TVLADVAALRVRAELEDSAEGTL------------------------------RLSHV-SLGVGD 697

  Fly   785 GASMCNCNPTGSLSKVCESNGGYCQCKPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYC 849
            ..|        .:||: ..:..:|:|.....|..|:.|.||.|..|                   
Zfish   698 SNS--------DVSKI-SLDVEHCECPWGYSGTSCELCIPGFYRVG------------------- 734

  Fly   850 DLITGQCQCVPNTYGRECNQCQPGYWNFPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSC 914
            .::.|. .|:|                      |:||.||..|| |.|.|:.|..:|||..||.|
Zfish   735 GILFGG-NCLP----------------------CECNDHATECD-INGECLGCAHNTTGPHCDQC 775

  Fly   915 LDGYYGNPLFGSEIGCRPCRCPETVASGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFF 979
            |.|:||:...|:...|:.|.||.|:||. ..:..|.|......:...||.||:|.:|:.|||.:|
Zfish   776 LPGFYGDASEGTPDDCQRCSCPLTLASN-NFSPTCQLQAPGEFICDQCQSGYTGDKCQRCADGYF 839

  Fly   980 GNP-DNGGTCSKCECSNNVDLYDTGNCDRQTGACLKCLYQTTGDHCELCKDGFFGDALQQ-NCQQ 1042
            |.| ..|..||.|||:.|||..:.|.||..||.||||:..|.|.|||.|:||::|||:|: |||.
Zfish   840 GEPVVPGQRCSPCECNGNVDPSEAGRCDTHTGECLKCVGHTAGPHCERCRDGYYGDAIQEKNCQA 904

  Fly  1043 CECDFLGTNNTIAHCDRFTGQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGAL----- 1102
            |.|...|:.:||  |:..||||.|..||.|..||:|.|.:..|.|||||..|.|:..|||     
Zfish   905 CGCYSNGSLSTI--CNLITGQCECKHNVVGKTCDRCQEGYHGINSGEGCRPCECNQSGALSASCD 967

  Fly  1103 ---------------------------------------HEQCNSYTGQCQCKPGFGGRACNQCQ 1128
                                                   |..||..||:|.|.|...|..|.||.
Zfish   968 EEGRCQCITGVTGDKCDRCHHGYYNFKENGCTACDCAHTHGNCNGQTGECICPPHTHGLKCEQCD 1032

  Fly  1129 AHYWGNPN-EKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPC--- 1189
            ..:||:.. ..|:.|.|...|::..|||..:|.|||.....|..|:.||.|| ..||.||.|   
Zfish  1033 EGHWGHDGVSGCKVCNCSVVGSSSSQCDLSSGQCVCALQFSGLTCDRCALGY-RNFPQCSACDCN 1096

  Fly  1190 ---------------------GEC-------------FNNWDLILSALEDA-------------- 1206
                                 |:|             ..:....||||..|              
Zfish  1097 PNGTRAQFCDEALGVCGCEDHGQCSCKDNVGGRGCDECKSGSFGLSALNPAGCSPCFCFGLSDVC 1161

  Fly  1207 -TTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNLLQNTSVS----LVDIEKLD-------- 1258
             ..:.::||..:  :|::.|.....|:.|     ::..|:....|    |:|:::|:        
Zfish  1162 EELSGLVRAPIV--LGSSPALLRVVSQSD-----LQGTLEGVYYSDDEMLLDVDQLNKLSLLTGP 1219

  Fly  1259 --------YETQSLRDQLQASHGRLSETEQNLDDIYNSLSLSGVELESLQ-------NHSR-LVQ 1307
                    |.    .::|.:..||||.|       ....:..||.|.:.:       .|.| ||.
Zfish  1220 YYWRLPQKYN----GNKLLSYGGRLSYT-------LTFFAQDGVGLANQEPQVLMRGGHLRKLVI 1273

  Fly  1308 QLSKELKENGIQLQESNIEGALNLTRHAYERVSNLSTLKDEA------NELASNTD--------- 1357
            ........|||:..:.:.     ||.|.::..:::|   |||      ..:.||.:         
Zfish  1274 YTDASAPANGIRSTQEHA-----LTEHKWKYFNSVS---DEAVSHADFMSVLSNLEYVIIKASYG 1330

  Fly  1358 --RNCKRVENLSNKIQAEADDLANNN---KLIE-------------------DYRAELTSLT--- 1395
              ....|:.|:|.:...|||:|....   :|:|                   .||..::.|.   
Zfish  1331 SGLQQSRISNISMETALEADELPEGGDVARLVEICECPPGYAGLSCQECAPGYYRQAVSELNMKG 1395

  Fly  1396 -----------------SQIPELNNQVC-----GKPGDPCD-----------------SLCG--- 1418
                             ||..:|:...|     ...|:.|.                 |||.   
Zfish  1396 RNRPLIQPCVPCRCSNHSQSCDLHTGQCLGCQHNTAGEHCHVCAAGYYGKVQGSVSDCSLCACPL 1460

  Fly  1419 ------------GAG---CGHC-----------------------GG---FLSCEHGAKTHSEEA 1442
                        |||   |..|                       ||   ..:|......||   
Zfish  1461 RGQSFSSTCVLEGAGDFRCDRCEEGYEGRYCERCAVGYFGNPSEPGGRCQVCACSESGSVHS--- 1522

  Fly  1443 LKVAKDAETAITSKK--------DQADQTIRALTQAKLNASEAYEKA----KRGFEQSERYLNQT 1495
               ..||.|.....|        ||.::....:.:..::.:::....    ....:.|...:|.|
Zfish  1523 ---VCDAHTGRCECKPGVRGHLCDQCEERHVLVHEQCVSCNDSCTGVLLDDLDALDVSITSVNLT 1584

  Fly  1496 NANIKLAENLFIALNNFQE-------------NKTASPSESKELAQKTLDL------------DL 1535
            ...:.....|....|..:|             ..||....|:.|:.:..||            |:
Zfish  1585 GVILAPYSQLMTIQNQTRELTSLMSWNQTPDYQLTAGEEHSRNLSGQITDLQQQVQSVFEDSGDV 1649

  Fly  1536 KLEPEEIETLGDQINRAVSSLKNVEAIIYRTKPDLDRVN----------NLQSIANATKEKADKI 1590
            .|..|:..|.|.|:   :..:.|:.:.|:.....:..||          |...:...|.|..:||
Zfish  1650 LLTSEQRFTQGKQL---LELINNIHSAIHGLVEQVSSVNVTLDEGLDEANSTFLLEETSETLEKI 1711

  Fly  1591 ---------------LDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQD-----------L 1629
                           |.||.||:|          |.:|.|.:...|.::..::           |
Zfish  1712 RSFNLTHCRNAAEIQLSSAVSVLE----------KVEDEISKPYRNNQIRRENISTTLNTHNLSL 1766

  Fly  1630 EKIDEETYSAEAPANNTAQQVEKLAKKVQKL---QNNIMKNDRDAKEITKEAGSVKLEAMRARGE 1691
            :::.|..|:|:...|.:.:.::.:......|   :||:...:.:.:...:||..:..:|:..   
Zfish  1767 QQVQESLYTAKTHNNQSRRLLQDIQSNTHTLTISRNNVSSLNHELETQVQEAQDLLTDALNI--- 1828

  Fly  1692 ANNLQSATSATNQTLTDRASRSENARERAKQLLQRASKLTVDTNAKLKDLNDLQTVY-LNKNQQL 1755
            |.::.:..:..::...|....|.:.|:....|:...:|         :|.  ||.|| ...:.|.
Zfish  1829 AEDMDNGATTLDELKNDLELWSPSLRKHVDSLVMDLTK---------RDA--LQLVYRAEDHAQA 1882

  Fly  1756 LRLQAEIGPLNKELNE 1771
            |..||:  .||..|:|
Zfish  1883 LSKQAQ--ALNSSLSE 1896

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 54..286 CDD:459653 69/261 (26%)
EGF_Lam 287..343 CDD:238012 21/55 (38%)
Laminin_EGF 355..415 CDD:395007 23/66 (35%)
Laminin_EGF 418..475 CDD:395007 18/59 (31%)
EGF_Lam 477..526 CDD:238012 19/49 (39%)
EGF_Lam 529..567 CDD:214543 9/53 (17%)
EGF_Lam 789..834 CDD:214543 11/44 (25%)
Laminin_EGF 837..885 CDD:395007 4/47 (9%)
Laminin_EGF 883..930 CDD:395007 22/46 (48%)
Laminin_EGF 933..988 CDD:395007 21/55 (38%)
Laminin_EGF 991..1035 CDD:395007 24/43 (56%)
Laminin_EGF 1043..1091 CDD:395007 22/47 (47%)
Laminin_EGF 1094..1142 CDD:395007 20/92 (22%)
Laminin_EGF 1142..1190 CDD:395007 21/71 (30%)
Mplasa_alph_rch 1228..>1771 CDD:275316 136/772 (18%)
cc_DmLAMB1-like_C 1717..1786 CDD:411973 16/56 (29%)
lama1NP_001030158.1 LamNT 25..275 CDD:214532 72/290 (25%)
EGF_Lam 277..324 CDD:238012 22/56 (39%)
EGF_Lam <364..390 CDD:238012 14/25 (56%)
Laminin_EGF 404..463 CDD:395007 20/64 (31%)
Laminin_EGF 461..506 CDD:395007 19/48 (40%)
Laminin_B 571..710 CDD:459652 37/200 (19%)
EGF_Lam 744..792 CDD:238012 23/70 (33%)
Laminin_EGF 809..849 CDD:395007 15/39 (38%)
EGF_Lam 851..903 CDD:238012 28/51 (55%)
Laminin_EGF 905..951 CDD:395007 22/47 (47%)
Laminin_EGF 954..1001 CDD:395007 5/46 (11%)
EGF_Lam 1000..1045 CDD:238012 14/44 (32%)
Laminin_EGF 1047..1095 CDD:395007 21/48 (44%)
Laminin_EGF 1093..1149 CDD:395007 8/55 (15%)
Laminin_B 1221..1363 CDD:459652 34/160 (21%)
EGF_Lam <1365..1385 CDD:238012 0/19 (0%)
Laminin_EGF 1407..1453 CDD:395007 6/45 (13%)
Laminin_EGF 1456..1509 CDD:395007 8/52 (15%)
Laminin_EGF 1512..>1549 CDD:395007 9/42 (21%)
Laminin_I 1580..1842 CDD:310534 48/277 (17%)
COG4372 1722..2043 CDD:443500 40/201 (20%)
Laminin_II 2015..2148 CDD:368703
LamG 2133..2281 CDD:238058
LamG 2310..2466 CDD:238058
LamG 2491..2641 CDD:238058
Laminin_G_1 2750..2877 CDD:395008
LamG 2897..3048 CDD:238058
Blue background indicates that the domain is not in the aligned region.

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