DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and LanB2

DIOPT Version :10

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_524006.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster


Alignment Length:1933 Identity:508/1933 - (26%)
Similarity:792/1933 - (40%) Gaps:505/1933 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 RLIVVIVL------ALLSWQWDPVDSQRPP-----QHGRRDRPKYPPNKFIKTHPC-----ERSS 53
            ||:::.||      |:|.       :||||     .|..|.      ..|:....|     ....
  Fly    15 RLLLIGVLFASCSTAILG-------AQRPPINSAGGHELRG------TTFMPALECYDPYGRPQK 66

  Fly    54 CYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQD-KKCFLCDTREETK------HDPYKNH 111
            |.|...|  ...:.::.:::|||..:...|||.:..|: |.|..|...:...      |||..  
  Fly    67 CLPEFIN--AAYQLQIESTNTCGEQNDNHFCIQTMNQNHKNCEFCKYNDHNPSFLTDLHDPQS-- 127

  Fly   112 RIGQIIYKTKPGTNIPTWWQSENGKEN------ATIQLDLEAEFHFTHLIITFTTFRPAAMYIER 170
                           |||||||...|.      ..:.|.|...:..|::.|.|.:.||.:..|.:
  Fly   128 ---------------PTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRILFRSPRPESFTIYK 177

  Fly   171 SFDFGQTWHIYRYFAYDCKE--SFPGVPTVL--ENITDVMCTSRYSNVEPSRNGEVIFRVL---P 228
            .......|..|::::..|::  |.|....:.  |.....:|||.||::.|.|:||:.|..|   |
  Fly   178 RTSESGPWIPYQFYSATCRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRP 242

  Fly   229 PNINVTDPYAEHVQNQLKMTNLRIQMTKLHKLGDNLL-DSRLENEEKYYYGISNMVVRGSCSCYG 292
            ..||.  ..:..:|..:..|::||.:.:|:..||.|. ||::  .:.|:|.||::.|...|.|.|
  Fly   243 SGINF--ERSGELQEWVTATDIRITLDRLNTFGDELFGDSQV--LKSYFYAISDIAVGARCKCNG 303

  Fly   293 HASQCLPLDPAFSQADNEDGMVHGR----CECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACK 353
            |||:|:|          ..|| ||.    |||.|||.|.:|:.|...:|||.||.:...:.|.||
  Fly   304 HASKCVP----------STGM-HGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECK 357

  Fly   354 KCECNDHAVSCHFDEAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFY-RDPEQDITSERVCQP 417
            .|.||..|..|.||..:|..:|  .||.|.:|..|..|.:||.|...|| ||       :..|..
  Fly   358 ACNCNGLADKCFFDANLFNRTG--HGGHCLDCRENRDGPNCERCKENFYMRD-------DGYCVN 413

  Fly   418 CDCDPQGSSDDGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNP 482
            |.|||.||.... |:|         .|.|.||..|||.:|::|.:.|:..   .|.||:.|.|:.
  Fly   414 CACDPVGSRSLQ-CNS---------HGKCQCKPGVTGDKCDRCDNNYYQF---GPHGCQQCGCDS 465

  Fly   483 LGTLNNS-GCVMRTGECKCKKYVTGKDCNQCMPETYGLSESPE-GCSLCNCDAGGSYDNYCDVIS 545
            .|:..|: .|...||.|.||:.|.|:.||:|.|..:.|.::.. ||:.|.|     |.:     :
  Fly   466 GGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPCFC-----YGH-----T 520

  Fly   546 GQCRCRPHMTGRSCSQPKQNY--FIP--LLPEVHEAEV------VDECISYGANGNCSLVAETPD 600
            .:|...|   |.|......|:  |..  ...::::.||      ....|...|.||..:..:.||
  Fly   521 SECMTAP---GYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQYSRSIGTTAQGNEHVYFQAPD 582

  Fly   601 GSFTGIGFTRVPENSELVF---TVGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGG 662
               ..:|..|...|.:|.|   .||.:..:...|.::.                          |
  Fly   583 ---RFLGDQRASYNRDLKFKLQLVGQVANTGVSDVILE--------------------------G 618

  Fly   663 CGELAAATSSETRIPF-----SLPDRSRQVVALNEVCLEAGKVYKFRIYFERKRHDVD-SPTATI 721
            .|       |...:|.     .:||             :..|.|.||::   :.||.. .|:.:.
  Fly   619 AG-------SRISLPIFAQGNGIPD-------------QGVKEYTFRLH---EHHDYQWQPSQSA 660

  Fly   722 -----LVDSLTLIPRIDVTPIFQGSVLADIRKKDYEKYNCKSSLYDMNYKSDPKCQNLDNILSVF 781
                 ::.:||.| :|..|...||..:                              ||::....
  Fly   661 RGFLSILSNLTAI-KIRATYSVQGEAI------------------------------LDDVELQT 694

  Fly   782 VHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKD 846
            .|.||:                  |:                |.|:                   
  Fly   695 AHRGAA------------------GH----------------PATW------------------- 706

  Fly   847 KYCDLITGQCQCVPNTYGRECNQCQPGYWNFP-------ECRVCQCNGHAATCDPIQGTCIDCQD 904
                  ..||.|.....|:.|..|.|||.:.|       .|..|.|:|||..||...|.|| ||.
  Fly   707 ------IEQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCI-CQH 764

  Fly   905 STTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVASGLAHADGCSLDTRNNNMLC-HCQEGYSG 968
            :|.|.:||.|..|:|||.|.|:...|:.|.||.         ||..|....:.::| .|.:||.|
  Fly   765 NTHGDNCDQCAKGFYGNALGGTPNDCKRCPCPN---------DGACLQINEDTVICTECPKGYFG 820

  Fly   969 SRCEICADNFFGNP----DNGGTCSKCECSNNVDLYDTGNCDRQTGACLKCLYQTTGDHCELCKD 1029
            ||||.|:|.|||:|    ....||..|:|:.|||....|||:|.||.||||::.|.|:||:.|..
  Fly   821 SRCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLS 885

  Fly  1030 GFFGDAL---QQNCQQCECDFLGT---NNTIAHCDRFTGQCPCLPNVQGVRCDQCAENHWKIASG 1088
            |.|||.|   ...|.:|.|...||   ..:|..||:.||||.|.|||.|..|.:|...::.|.||
  Fly   886 GHFGDPLALPHGRCDRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSG 950

  Fly  1089 EGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQCQAHYWGNPNEKCQPCECDQFGAADFQ 1153
            .|||:|.|||:|:.:..|:.|:|||.|:||..|:.|:||:.:::|..:|.|:|||||:.|:..||
  Fly   951 NGCENCLCDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQ 1015

  Fly  1154 CDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGECFNNWDLILSALEDATTATILRAK--- 1215
            || :.|.|.|::.:.|.:|:.|......:...|..|.:|:|       .::||  |.:.|||   
  Fly  1016 CD-QNGQCPCNDNVEGRRCDRCKENKYDRHRGCIDCPDCYN-------LVQDA--ADLHRAKLFN 1070

  Fly  1216 ------EIKQVGATGAYTSEFSELDKKLQHIRNLLQNTSVSLVDIEKLDYETQSLRDQLQASHGR 1274
                  ||.:...|..     .|.:.||:.::             ||:....|..||. ....|:
  Fly  1071 LSQTLDEIARTPVTND-----DEFEAKLKAVQ-------------EKVAVLAQDARDN-SGDGGQ 1116

  Fly  1275 -----LSETEQNLDDIYNSL--------SLSGVELESLQNHSRLVQQLSKELKENGIQLQES--- 1323
                 :.:..::||.:...|        ..:| |::..:.:..::.|:::..|:   :||::   
  Fly  1117 TYAEVIDDLHKHLDSVREHLVSADKFQADANG-EIDRARQNYTILDQITENAKK---ELQQALDL 1177

  Fly  1324 -NIEGALNLTRHAYERVSNLSTLKDEANELASNTDRNCKRVENLSNKIQAEADDLANNNKLIEDY 1387
             |.|||..|.| |.|:........::.::::       :....|::|:::||.....|.|..:|.
  Fly  1178 LNDEGAQALAR-AKEKSVEFGQQSEQISDIS-------REARALADKLESEAQFDLKNAKDAKDA 1234

  Fly  1388 RAELTSLTSQIPELNNQVCGKPGDPCDSLCGGAGCGHCGGFLSCEHGAKTHSEEALKVAKDAETA 1452
            ..:...|                                        ||:..:..||:..:..:.
  Fly  1235 VEKAHQL----------------------------------------AKSAIDLQLKIGTELRSE 1259

  Fly  1453 ITSKKDQADQTIRALTQAKLNASEAYEKAKRGFEQSERYLNQTNANIKLAENLFIALNNFQENKT 1517
            :..:.....|::..:.|   .:.||..||...::.:...||..|...:..    |.::..:::..
  Fly  1260 VGLELSHVKQSLGTVVQ---TSKEALRKANEVYDTALTLLNDVNRQTQPE----IDISQLKKDAV 1317

  Fly  1518 ASPSESKELAQKTLDL---------DLKLEPEEIETLGDQINRA-VSSLKNVEAIIYRTKPDLDR 1572
            |:...:.||.::..:|         |.:.|.|..|.|   :.|| ...|:::| ::.|.|...|:
  Fly  1318 AANERADELLKQITELSNSNGELFADFETEQELTEAL---LKRAEQQQLEDIE-LLERAKAAHDK 1378

  Fly  1573 VNNLQSIANATK--EKADKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDLEKIDEE 1635
                     |||  |:.|..|..||:..|.||      |...| :|:::.:.|.|.|.:..|::|
  Fly  1379 ---------ATKAVEQGDNTLKEANNTYEKLA------GFQSD-VQRSSESAEKALQTVPNIEKE 1427

  Fly  1636 TYSAEA----------PANNTAQQVEKLAKKVQ-KLQNNIMKNDRDAKEITKEAGSVKLEAMRAR 1689
            ..:||:          .||..|.:.:|.|::.| |......|   ||:.|.::|...|:.|...|
  Fly  1428 IQNAESLISQAEEALDGANKNANEAKKNAQEAQLKYAEQASK---DAELIRRKANETKVAARNLR 1489

  Fly  1690 GEANNLQSATSATNQ---TLTDRASRSENARERAKQLL-------QRASKLTVDTNA-------K 1737
            .||:.|......|..   .|.:.:::.:|..:.||:.:       |.|.|.....||       :
  Fly  1490 EEADQLNHRVKLTEMDIFKLEESSTKDDNLVDDAKRKVGQAKADTQEAQKQIEKANADLTAIKDE 1554

  Fly  1738 LKDLNDLQTVYLNKNQQLLRLQAEIGPLNKELNEHLIHIKERGSHYRQ 1785
            |::|.|:.|..|:      ||:..:..:..|:|.  :::..|...||:
  Fly  1555 LENLKDINTGDLD------RLENRLATVEGEINR--VNLTGRIEKYRE 1594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 54..286 CDD:459653 67/252 (27%)
EGF_Lam 287..343 CDD:238012 25/59 (42%)
Laminin_EGF 355..415 CDD:395007 22/60 (37%)
Laminin_EGF 418..475 CDD:395007 19/56 (34%)
EGF_Lam 477..526 CDD:238012 17/50 (34%)
EGF_Lam 529..567 CDD:214543 8/39 (21%)
EGF_Lam 789..834 CDD:214543 3/44 (7%)
Laminin_EGF 837..885 CDD:395007 12/54 (22%)
Laminin_EGF 883..930 CDD:395007 23/46 (50%)
Laminin_EGF 933..988 CDD:395007 21/59 (36%)
Laminin_EGF 991..1035 CDD:395007 23/43 (53%)
Laminin_EGF 1043..1091 CDD:395007 21/50 (42%)
Laminin_EGF 1094..1142 CDD:395007 20/47 (43%)
Laminin_EGF 1142..1190 CDD:395007 16/47 (34%)
Mplasa_alph_rch 1228..>1771 CDD:275316 121/599 (20%)
cc_DmLAMB1-like_C 1717..1786 CDD:411973 19/83 (23%)
LanB2NP_524006.1 LamNT 61..296 CDD:214532 66/257 (26%)
EGF_Lam 298..347 CDD:238012 25/59 (42%)
Laminin_EGF 359..414 CDD:395007 23/63 (37%)
EGF_Lam 414..458 CDD:214543 19/56 (34%)
Laminin_EGF 461..511 CDD:395007 17/49 (35%)
LamB 572..697 CDD:214597 34/207 (16%)
EGF_Lam 743..791 CDD:238012 23/48 (48%)
EGF_Lam 793..836 CDD:214543 21/51 (41%)
Laminin_EGF 847..897 CDD:395007 25/49 (51%)
Laminin_EGF 902..953 CDD:395007 21/50 (42%)
EGF_Lam 956..1001 CDD:214543 19/44 (43%)
Laminin_EGF 1004..1046 CDD:395007 15/42 (36%)
SMC_prok_B <1054..1621 CDD:274008 135/659 (20%)

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