DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and LanA

DIOPT Version :10

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster


Alignment Length:2857 Identity:582/2857 - (20%)
Similarity:872/2857 - (30%) Gaps:1281/2857 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 PATGNLLIGRENRLTASSTCG--LHSPERFCIL------------SHLQDKKCFLCDTREETKHD 106
            |...||..||  ::.|::|||  ...||.:|.|            |.:|.:.|..||.....::.
  Fly    26 PPYFNLATGR--KIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTVPERNH 88

  Fly   107 PYKNHRIGQIIYKTKPGTNIPTWWQS---ENGKE--NATIQLDLEAEFHFTHLIITF-TTFRPAA 165
            |.:|         ...||.  .||||   ..|.:  ...:.::.|.|||..:|.|.. .:.||..
  Fly    89 PPEN---------AIDGTE--AWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPRPGL 142

  Fly   166 MYIERSFDFGQTWHIYRYFA---YDCKESFPGVPTVLENIT---DVMCTSRYSNVEPSRNGEVIF 224
            ..:|:|.|:|:||..:::|:   .|| |::.|..| .:.||   ||:||:.||.:.|..|||:..
  Fly   143 WTLEKSTDYGKTWTPWQHFSDTPADC-ETYFGKDT-YKPITRDDDVICTTEYSKIVPLENGEIPV 205

  Fly   225 RVLPPNINVTDPYAEHV-QNQLKMTNLRIQMTKLHKLGDNLLDSRLEN---EEKYYYGISNMVVR 285
            .:|....:.|:.:...| |...:.||:||::.:...|..:|:....::   ..:|:|.|.::.:.
  Fly   206 MLLNERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDISIG 270

  Fly   286 GSCSCYGHASQCLPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTN 350
            |.|.|.|||..|...||       :..:....|.|.|:|.|:.|.||...|....|:    :.||
  Fly   271 GRCMCNGHADTCDVKDP-------KSPVRILACRCQHHTCGIQCNECCPGFEQKKWR----QNTN 324

  Fly   351 A----CKKCECNDHAVSCHFDEAVFTASG--------FVSGGVCDNCLHNTRGQHCEECMPYFYR 403
            |    |:.|.|:.|:..|.:||.| ...|        :..||||.||.|||.|.:|.:|.|.:||
  Fly   325 ARPFNCEPCNCHGHSNECKYDEEV-NRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYR 388

  Fly   404 DP-----EQDITS---------------------------------------------------- 411
            ..     |.|:.|                                                    
  Fly   389 PKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLN 453

  Fly   412 ----------------------------------------------------------------- 411
                                                                             
  Fly   454 GTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGECKCLT 518

  Fly   412 -------ER---------VCQPCDCDPQGSSDD-------------------------------- 428
                   ||         .|..||||.||:..:                                
  Fly   519 NFGGDNCERCKHGYFNYPTCSYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYPD 583

  Fly   429 -------------------GICDSLNEL------------------------------------- 437
                               |.|:.||..                                     
  Fly   584 CKPCNCSSTGSSAITCDNTGKCNCLNNFAGKQCTLCTAGYYSYPDCLPCHCDSHGSQGVSCNSDG 648

  Fly   438 ----------------EEG---------------------------AVAGACHCKAFVTGRRCNQ 459
                            :||                           .|...|.||..||||.||:
  Fly   649 QCLCQPNFDGRQCDSCKEGFYNFPSCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRICNE 713

  Fly   460 CKDGYWNLQSDNPEGCEPCTCNPLGTLNN-SGCVMRTGECKCKKYVTGKDCNQCMPETYGL-SES 522
            ||..||||...|.||||.|.|...||::. ..|..::|:|.||.:..|:.|.:|...|:.| |.|
  Fly   714 CKPLYWNLNISNTEGCEICDCWTDGTISALDTCTSKSGQCPCKPHTQGRRCQECRDGTFDLDSAS 778

  Fly   523 PEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQNYFIP------------------ 569
            ..||..|:||.|||:.:.||.|||||:|.|.:||.:|:||...:|.|                  
  Fly   779 LFGCKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQFQYEYEDGSLPSGT 843

  Fly   570 ----------------------------------------------------------------- 569
                                                                             
  Fly   844 QVRYDYDEAAFPGFSSKGYVVFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNAENVTATISVTSDN 908

  Fly   570 ---------------------------------------------------------LLPEV-HE 576
                                                                     |||.. :|
  Fly   909 PLEVDQHVKVLLQPTSEPQFVTVAGPLGVKPSAIVLDPGRYVFTTKANKNVMLDYFVLLPAAYYE 973

  Fly   577 AEVVDECISYGAN-GNCSLV-------------AETPDGSFTGIG-----------FTRVPENSE 616
            |.::...||.... ||..|.             |.||   |. ||           :|. ||:.:
  Fly   974 AGILTRHISNPCELGNMELCRHYKYASVEVFSPAATP---FV-IGENSKPTNPVETYTD-PEHLQ 1033

  Fly   617 LVFTVGDI----------------PRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGG--- 662
            :|..||||                |||..|..||.|.| .|...::.:|.|...|..|.|..   
  Fly  1034 IVSHVGDIPVLSGSQNELHYIVDVPRSGRYIFVIDYIS-DRNFPDSYYINLKLKDNPDSETSVLL 1097

  Fly   663 --------CGE----------------------LAAATSSETRIPF----SLPDRSRQVVALN-- 691
                    |..                      ::|.....:|.|.    ::|.....:..:|  
  Fly  1098 YPCLYSTICRTSVNEDGMEKSFYINKEDLQPVIISADIEDGSRFPIISVTAIPVDQWSIDYINPS 1162

  Fly   692 EVCL---EAGKVYKFR-------IYFERKRHD--------------------VDSPT-ATILVDS 725
            .||:   :.....|||       |.||....|                    :||.. |||:::|
  Fly  1163 PVCVIHDQQCATPKFRSVPDSKKIEFETDHEDRIATNKPPYASLDERVKLVHLDSQNEATIVIES 1227

  Fly   726 LTLIPRIDVT----------------------------------------------------PIF 738
                 ::|.|                                                    |..
  Fly  1228 -----KVDATKPNLFVILVKYYQPSHPKYQVYYTLTAGKNQYDGKFDIQHCPSSSGCRGVIRPAG 1287

  Fly   739 QGSVLADIRKK-------------DY------EKY------------------NCKSSLYDMNYK 766
            :||...|...|             ||      ::|                  ||....:.:.:.
  Fly  1288 EGSFEIDDEFKFTITTDRSQSVWLDYLVVVPLKQYNDDLLVEETFDQTKEFIQNCGHDHFHITHN 1352

  Fly   767 SDPKCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCK-------------------- 811
            :...|:.....|:...:.||..|||:..||.|..|...||.||||                    
  Fly  1353 ASDFCKKSVFSLTADYNSGALPCNCDYAGSTSFECHPFGGQCQCKPNVIERTCGACRSRYYGFPD 1417

  Fly   812 ----------------------PNVVGRQCDQCAPGTYGFGPE-GCKACDCNSIG--SKDKYCDL 851
                                  |||:|..|::|||.||||... ||:.|.||.:|  :.:..|||
  Fly  1418 CKPCKCPNSAMCEPTTGECMCPPNVIGDLCEKCAPNTYGFHQVIGCEECACNPMGIANGNSQCDL 1482

  Fly   852 ITGQCQCVPNTYGRECNQCQPGYWNFPEC------------------------------------ 880
            ..|.|:|..|..||.|:.|..||:|||.|                                    
  Fly  1483 FNGTCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGTELEVCDKIDGACFCKKNVVGRDCDQC 1547

  Fly   881 ----------------------------------------------------------------- 880
                                                                             
  Fly  1548 VDGTYNLQESNPDGCTTCFCFGKTSRCDSAYLRVYNVSLLKHVSITTPEFHEESIKFDMWPVPAD 1612

  Fly   881 ----------------------------------------------------------------- 880
                                                                             
  Fly  1613 EILLNETTLKADFTLREVNDERPAYFGVLDYLLNQNNHISAYGGDLAYTLHFTSGFDGKYIVAPD 1677

  Fly   881 --------------------------RV------------------------------------- 882
                                      ||                                     
  Fly  1678 VILFSEHNALVHTSYEQPSRNEPFTNRVNIVESNFQTISGKPVSRADFMMVLRDLKVIFIRANYW 1742

  Fly   883 ----------------------------------------------------------------- 882
                                                                             
  Fly  1743 EQTLVTHLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYSGHSCEDCAPGYYRDPSGPYGGYCI 1807

  Fly   883 -CQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVASGLAHA 946
             |:||||:.|||...|.|..||..|.|..|:.|:.|||||...|:...|..|.||....|. ..|
  Fly  1808 PCECNGHSETCDCATGICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMICACPLPFDSN-NFA 1871

  Fly   947 DGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPDN-GGTCSKCECSNNVDLYDTGNCDRQTG 1010
            ..|.:....:.:.|.|:.||:|.|||.||:.|:|.|:: |..|..||||.|::..|.|:||.:||
  Fly  1872 TSCEISESGDQIHCECKPGYTGPRCESCANGFYGEPESIGQVCKPCECSGNINPEDQGSCDTRTG 1936

  Fly  1011 ACLKCLYQTTGDHCELCKDGFFGDALQ-QNCQQCECDFLGTNNTIAHCDRFTGQCPCLPNVQGVR 1074
            .||:||..|.|..|.||..||:|||:: :|||.|:||.|||..    ||.|.|.|.|..||.|.|
  Fly  1937 ECLRCLNNTFGAACNLCAPGFYGDAIKLKNCQSCDCDDLGTQT----CDPFVGVCTCHENVIGDR 1997

  Fly  1075 CDQCAENHWKIASGEGCESCNCDPIGALHE--QCNSYTGQCQCKPGFGGRACNQCQAHYWGNPNE 1137
            ||:|..:|:...||.||.:|:|   ||...  ||:.:||.|.||.|..||.|::|...:|....:
  Fly  1998 CDRCKPDHYGFESGVGCRACDC---GAASNSTQCDPHTGHCACKSGVTGRQCDRCAVDHWKYEKD 2059

  Fly  1138 KCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYI-----GQFPHCSPCGECFNNWD 1197
            .|.||.|:|..:..|.|:..||.|.|..|:.|.:|:.|...::     |       |.||.|...
  Fly  2060 GCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGDRCDACPNRWVLIKDEG-------CQECNNCHH 2117

  Fly  1198 LIL-----------SALEDATTATILRAKEIKQVGATGAYTSE----FSELDKKLQHIRNLLQNT 1247
            .:|           |.|||..:.|:            ..:||:    :.:|..:|:....||...
  Fly  2118 ALLDVTDRMRYQIDSVLEDFNSVTL------------AFFTSQKLNYYDQLADELEPKVKLLDPN 2170

  Fly  1248 SVSLVDIEKLDYETQSLRDQLQASHGRLSETEQNLDDI--YNSLSLSGVEL---ESLQNHSRL-- 1305
            ||.|...:|.:.|.:|   ..::...::::|..|..||  .:|.:|..:.:   |::::..:.  
  Fly  2171 SVDLSPSKKANSELES---DAKSYAKQVNQTLANAFDIRERSSTTLGNITVAYDEAVKSADQAKE 2232

  Fly  1306 ----VQQLSKELKE--------------------NGIQLQESNIEGALNLTRHAYERVS------ 1340
                |:.|||.|:.                    ||..::.:..|..|...|..||.|:      
  Fly  2233 AIASVEALSKNLEAAASTKIDAALEQAQHILGQINGTSIELTPNEQVLEKARKLYEEVNTLVLPI 2297

  Fly  1341 -----NLSTLKDEANELASNTD------------------RNCKRVENLSN---------KIQAE 1373
                 :|:.||::..|.:.:.:                  ||....:...|         |:|||
  Fly  2298 KAQNKSLNALKNDIGEFSDHLEDLFNWSEASQAKSADVERRNVANQKAFDNSKFDTVSEQKLQAE 2362

  Fly  1374 ------ADDLANNNKLIEDYRAELTSLTSQIPELNNQVCGKPGDPCDSLCGGAGCGHCGGFLSCE 1432
                  .:.|.|.:..:.....:|.:|...:.|||:                             
  Fly  2363 KNIKDAGNFLINGDLTLNQINQKLDNLRDALNELNS----------------------------- 2398

  Fly  1433 HGAKTHSEEALKVAKDAETAITSKKDQADQ-----------------TIRALTQAKLNASEAYEK 1480
              ...:.:|.|.|.:|......:..|||:|                 .:.|..:..:.|:.||..
  Fly  2399 --FNKNVDEELPVREDQHKEADALTDQAEQKAAELAIKAQDLAAQYTDMTASAEPAIKAATAYSG 2461

  Fly  1481 AKRGFEQSERYLNQTNANIKLAENLFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETL 1545
            .....|.::          ||:::...|..| ..:||....|...||. |...||          
  Fly  2462 IVEAVEAAQ----------KLSQDAISAAGN-ATDKTDGIEERAHLAD-TGSTDL---------- 2504

  Fly  1546 GDQINRAVSSLKNVEAIIY-RTKPDLDRVNNLQSIANATKEKADKILDSANSVVESLAAADE--- 1606
               :.||..||:.|:..:. |......:|..:.::.|||:.:    |...|.:::.|.|..:   
  Fly  2505 ---LQRARQSLQKVQDDLEPRLNASAGKVQKISAVNNATEHQ----LKDINKLIDQLPAESQRDM 2562

  Fly  1607 ---SQGKAKDAIQ--------------QANSNIELA---GQDLEKIDEETYSAEAPANNTAQQVE 1651
               |...|.||::              |....:|.|   .:||:..:::...|....::....|.
  Fly  2563 WKNSNANASDALEILKNVLEILEPVSVQTPKELEKAHGINRDLDLTNKDVSQANKQLDDVEGSVS 2627

  Fly  1652 KLAKKVQKLQNNIMKNDRDAKEITKEAGSVKLEAMRARGEANNLQSATSATNQTLTDRASRSENA 1716
            ||::..:.::....:....::::.:|..::|.:...||..||:::...:....|:.:.     ..
  Fly  2628 KLSELAEDIEEQQHRVGSQSRQLGQEIENLKAQVEAARQLANSIKVGVNFKPSTILEL-----KT 2687

  Fly  1717 RERAKQLLQRASKLTV--------------DTNAKLKDLNDLQTVYLNKNQQLLRLQAEIGP 1764
            .|:.|.|..|.:..|.              :.|...:..||...|.:.....:|.:....||
  Fly  2688 PEKTKLLATRTNLSTYFRTTEPSGFLLYLGNDNKTAQKNNDFVAVEIVNGYPILTIDLGNGP 2749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 54..286 CDD:459653 72/259 (28%)
EGF_Lam 287..343 CDD:238012 18/55 (33%)
Laminin_EGF 355..415 CDD:395007 28/205 (14%)
Laminin_EGF 418..475 CDD:395007 30/187 (16%)
EGF_Lam 477..526 CDD:238012 16/50 (32%)
EGF_Lam 529..567 CDD:214543 20/37 (54%)
EGF_Lam 789..834 CDD:214543 25/87 (29%)
Laminin_EGF 837..885 CDD:395007 24/344 (7%)
Laminin_EGF 883..930 CDD:395007 22/46 (48%)
Laminin_EGF 933..988 CDD:395007 20/55 (36%)
Laminin_EGF 991..1035 CDD:395007 23/43 (53%)
Laminin_EGF 1043..1091 CDD:395007 22/47 (47%)
Laminin_EGF 1094..1142 CDD:395007 18/49 (37%)
Laminin_EGF 1142..1190 CDD:395007 14/52 (27%)
Mplasa_alph_rch 1228..>1771 CDD:275316 120/671 (18%)
cc_DmLAMB1-like_C 1717..1786 CDD:411973 12/62 (19%)
LanANP_476617.1 LamNT 18..271 CDD:214532 72/259 (28%)
EGF_Lam 272..>314 CDD:238012 16/48 (33%)
EGF_Lam 332..389 CDD:238012 22/57 (39%)
EGF_Lam 402..443 CDD:238012 0/40 (0%)
Laminin_EGF 448..497 CDD:395007 0/48 (0%)
Laminin_EGF 495..543 CDD:395007 4/47 (9%)
Laminin_EGF 541..589 CDD:395007 6/47 (13%)
Laminin_EGF 587..634 CDD:395007 4/46 (9%)
Laminin_EGF 632..679 CDD:395007 2/46 (4%)
Laminin_EGF 677..729 CDD:395007 18/51 (35%)
Laminin_EGF 732..782 CDD:395007 16/49 (33%)
EGF_Lam 785..828 CDD:238012 22/42 (52%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 0/134 (0%)
Laminin_EGF 1375..1423 CDD:395007 13/47 (28%)
EGF_Lam 1420..1457 CDD:238012 10/36 (28%)
Laminin_EGF 1466..1516 CDD:395007 21/49 (43%)
Laminin_EGF 1514..1562 CDD:395007 0/47 (0%)
LamB 1632..1760 CDD:214597 2/127 (2%)
Laminin_EGF <1775..1801 CDD:395007 0/25 (0%)
EGF_Lam 1808..1851 CDD:238012 21/42 (50%)
EGF_Lam 1859..1907 CDD:214543 18/48 (38%)
EGF_Lam 1916..1968 CDD:238012 26/51 (51%)
EGF_Lam 1969..2015 CDD:238012 23/49 (47%)
EGF_Lam 2016..>2054 CDD:238012 16/40 (40%)
EGF_Lam 2063..>2097 CDD:238012 13/33 (39%)
Laminin_I 2134..2385 CDD:310534 49/265 (18%)
SMC_prok_B 2356..>2705 CDD:274008 75/413 (18%)
Laminin_II 2566..2700 CDD:368703 24/138 (17%)
LamG 2674..2843 CDD:238058 13/81 (16%)
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Blue background indicates that the domain is not in the aligned region.

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