DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and Megf8

DIOPT Version :10

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_609180.3 Gene:Megf8 / 34099 FlyBaseID:FBgn0031981 Length:2892 Species:Drosophila melanogaster


Alignment Length:1837 Identity:343/1837 - (18%)
Similarity:546/1837 - (29%) Gaps:760/1837 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   286 GSCSCYGHASQCLPLDPAFSQADNED----GM--VHGRCECTHNTKGMNCEECEDFFND------ 338
            |:||...::|.....:.|::|..:.|    |:  .|...:||:.....||.....:..|      
  Fly  1159 GNCSLALNSSSHHDAEWAYAQCPDVDECGLGLHDCHKEAKCTNTQGSYNCHCRRGYIGDGKFSCV 1223

  Fly   339 -----------------------LPWKPAFGKKTNACKKCECNDHAVSCHFDEAVFTASGFVSGG 380
                                   |.|..|     :....|.||:|: :|  :|.:         |
  Fly  1224 RTCYELCQNGNCSGPPDYTCRCALGWTGA-----DCGLSCGCNNHS-TC--NERL---------G 1271

  Fly   381 VCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSDDGICDSLNELEEGAVAGA 445
            .||.|...:.|:.||.|....|    .:.|:...|.||:|:..|:.|.|:|:..|        |.
  Fly  1272 KCDQCQDWSEGEKCERCRQGSY----GNATAPHGCLPCECNGHGNQDLGVCNVSN--------GE 1324

  Fly   446 CHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPC--TCNPLGTLNNS---------------GCVM 493
            |:||....|..|..|..||:.    :|.|...|  .|...|.|.|.               |..:
  Fly  1325 CYCKDNTQGLNCELCAPGYYG----DPRGGGKCYYQCESRGILTNIGKSAIGSYQSYRSPWGASL 1385

  Fly   494 RTGEC---------KCKKYV---------TGKDCNQ-------CMPETYGLSE------------ 521
            ...||         :.:|.:         ...||::       .:|:..|.::            
  Fly  1386 EVKECLWILQPKTLQAEKSLLQLEFQWQSLAMDCDENAVYIYDSLPDLTGATQQNQLLAVVCAPY 1450

  Fly   522 -------------------------------------------SPEGCSL---CNCDAG--GS-- 536
                                                       ||..|..   |.|.||  |:  
  Fly  1451 SSPRIIEARSSHVTVHYKQGSERRHFGFNALYSVMNCVAGSCISPHICDAQQRCVCPAGYVGASC 1515

  Fly   537 -------------YDNYCDVISGQCRC-RPHMTGRSC-SQPKQNYFIPLLPEVHEAEVVDECIS- 585
                         ...:||...|:|.| ..:..|..| :..::|:.:  :.|:...:::.|.:. 
  Fly  1516 EIEICPSNCNAKRMQGFCDTEYGRCICSNANYAGADCGTLVQRNHLV--MTELFNTQLLSESLEH 1578

  Fly   586 -------YGANGNC-----------------------------------SLVAETPDGS------ 602
                   :|.:.|.                                   ::.:.||:..      
  Fly  1579 LRKTIPRFGHSVNADRRGSLWMFGGYSPNHGPLNDFRQFDTKNSTWLQVTVESSTPEDRMPLGRY 1643

  Fly   603 ---------------FTGIGFTRVPENSEL-----VFTVG--------------------DIPRS 627
                           :.|||     .||:|     :|::.                    |:|..
  Fly  1644 FHASEIYVKKQIIYIYGGIG-----ANSQLLNDFWMFSIQNQRWSQIKVEVEPPEADYEVDVPPP 1703

  Fly   628 MPYDAV--IRYQ-------------STSR-----------GDW---------------------- 644
            :....:  ||||             :.||           |.|                      
  Fly  1704 LAGHTLTHIRYQEHESLILLGGLSLNKSRPLELWEFNLDTGRWQQLAAVGARMPVLYGHTSVYHQ 1768

  Fly   645 ENAFITLVRPDQVDPEGGCGELAAATSSETRI--------PFSLPDRSR----QVVALNEVCLEA 697
            |...:.|......:|:.....|.....|.|.:        |.||..|:|    .|...:.:.|..
  Fly  1769 ETNSVYLFGGYSTEPQSNLYALDLQKLSWTELPSFRELNSPASLLPRARYFHSAVTTEHYMILYG 1833

  Fly   698 GKVYKFR--------IY----FERKRHDVD---SPTATILVDSLTLIPRIDVTPIFQG------- 740
            |:...|.        :|    :.|...||:   ...|:...:.:.:.|......:..|       
  Fly  1834 GRTQPFNGTDVLIAYVYACNQWVRLTEDVELIGRVPASSYAEDMAIDPDTGAIYVIGGWDGSSTH 1898

  Fly   741 SVLADIRKKD-------YEKYNCKS---------------SLYDMNYKSDPKCQNLDNILSVFVH 783
            |.:..|...|       ..||.|:.               |.:..::...| |.|.:..|  .|:
  Fly  1899 SHVTKITLPDDICQLWSNGKYQCRHYMGCSYCTIQNTYSYSSHCFSHGRTP-CANHNGTL--VVN 1960

  Fly   784 DGASMCNCNPTGSLSKVCES--NGGYC--------QCKPNVVGRQCDQCAPGTYG-FGPEGCKAC 837
            :||:   |:.....|:.|.|  ..|.|        :..|  |...||.|  |..| ..|.|   .
  Fly  1961 NGAA---CDDDWMASRNCSSFATCGACLAAWPTHQEVAP--VCHWCDDC--GIRGRCVPAG---V 2015

  Fly   838 DCNSIGSKDKYCDL-----ITGQCQCVPNTYGRECNQC--QPG-YWNFPECRVCQC--------N 886
            ||   |.:..:|:.     :.|.|. :|..|...|..|  ||. .|...|....:|        |
  Fly  2016 DC---GRRSAWCNKELSVGVLGLCP-LPQCYQLSCESCMLQPQCNWARNELGTVECIAKELVEKN 2076

  Fly   887 GHAAT------CDPIQ--GTCI---------DCQDSTTGYSCDS-------CLDGYYGNPLFGSE 927
            .:...      |...:  ..|:         :|:.||....|.:       |..|..|..|..||
  Fly  2077 QYRVVESCPLPCHTYENCSLCLSQTPTQDHQECKWSTMLNLCLTPSSQPLLCAGGVCGLVLEASE 2141

  Fly   928 IGCRPCRCPE-----TVASGL---AHADGCSLDTRNNNMLC------HCQEGYSGSRCEICADNF 978
            :.    ||||     |..|..   ||...|:.:..|.:.:|      |.||..|||.|::    .
  Fly  2142 LQ----RCPEPCHVYTQCSSCLEHAHCGWCAREGFNGDGICTEGALEHKQEHPSGSTCDL----I 2198

  Fly   979 FGNPDNGGTCS----------KC----ECSNNVDLYDTGNCDRQTGACL--------KCL----Y 1017
            :.:..|....:          :|    ||.|.     ..|||..:..|:        ||:    |
  Fly  2199 YASWRNDSQLTHADVVSWHYVQCPAENECING-----HHNCDTVSEQCIDLDTAVGYKCVCAQGY 2258

  Fly  1018 QTTGDHC-ELCKDGFFGDALQQNC---QQCECDF--LGTNNTI-------AHCDRFTGQCPCLP- 1068
            :.....| .:|..|    .::.||   .||:|||  :|.|.:|       ::|:..:....||. 
  Fly  2259 REEQGACLPVCSQG----CVRGNCVSPDQCQCDFGYVGANCSIQCLCNGHSNCESSSRLDICLKC 2319

  Fly  1069 --NVQGVRCDQC--------AENHWKIASGEGCESC--------------NCDP---------IG 1100
              |..|.:|::|        .|.|       .|:.|              :.||         :.
  Fly  2320 HNNTMGEQCEKCQPLFVGNPREGH-------ACQPCLDYCHGHSDVCVAYDADPAVFNMTRSELE 2377

  Fly  1101 ALHEQCNSYTGQC-QCKPGFGGRACNQCQAHYWGNP---NEKCQPCECDQFGAADFQCDRETG-- 1159
            .:.::..:|...| :|.....|..|:.|...|:...   :::|:||:|...|..   ||..||  
  Fly  2378 RILQEGPAYNATCLRCGNHTAGDRCDSCLTGYFRGSEDLHKECRPCQCHGHGNI---CDPVTGEK 2439

  Fly  1160 -NC--------VCHEGIGG---------YKCNECARGYIGQFPHCSPCGE--------CFNNWDL 1198
             ||        .|..| ||         .:|::|...|.|.......|.:        ||:    
  Fly  2440 CNCANNTESDATCTAG-GGKNSAQLCWMVQCSKCRDSYAGNPTDGHQCYKQITVESRMCFD---- 2499

  Fly  1199 ILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNLLQNTSVSLVDIEKLDYETQS 1263
                           ||.|::..:..|..       |..|.:..::|...:: |||..:...||.
  Fly  2500 ---------------AKPIEECKSKPAAL-------KPGQTVFFVIQPRFMN-VDIRIIIDVTQG 2541

  Fly  1264 LRDQLQASHGRLSETEQN---------LDDIYNSLSLSGVELE-------SLQNHSRL-VQQL-S 1310
            ..|...:........|.|         ||:.||    .|.:::       :|..|..: :|:| |
  Fly  2542 ELDVFMSPQDDSFIVETNETTGYHEIFLDNRYN----WGPKIKREHPLNVALPRHDNVTIQKLFS 2602

  Fly  1311 KELKENG------------------IQLQESNIEGALNL---TRHAYERVSNLSTLKDEANELAS 1354
            .|.:..|                  .|||:....|..|.   .:||          ||.:..:..
  Fly  2603 PERRIGGGGLGGGGGERIGANTYYVPQLQDCKSHGGHNFIVKDQHA----------KDLSTHVTL 2657

  Fly  1355 NTDRNCKRVENLSNKIQAEADDLANNNKLIEDYRAELTSLTSQIPELNNQVCGKPGDPCDSLCGG 1419
            |......|:..|.|::.......|:|   :...|..:....|..||.:                 
  Fly  2658 NHCNTLLRLFGLKNRLVLTLPQHAHN---LSATRFFIALRASSGPEPS----------------- 2702

  Fly  1420 AGCGHCGGFLSCEHGAKTHSEEALKVAKD----------------AETAITSKKDQADQTIRALT 1468
                         :|:....::.|.:  |                |...|..|..||....||..
  Fly  2703 -------------YGSVVFRQDQLHI--DLFVFFSVFFSCFFLFLAVCVIVWKVKQAADLRRARR 2752

  Fly  1469 QAKLNASEAYEKAKRGFEQSERYLNQTNANIKLAENLFIALNNFQENK---TASPSESKELAQKT 1530
            |   :..|....|||.|.|                 :|:|.|....:.   |:|.|.::.:.|:.
  Fly  2753 Q---HVVEMLHLAKRPFAQ-----------------IFLASNGLDMDSPQPTSSSSSARAMRQRA 2797

  Fly  1531 LDLDLKLEPEEIETLGD 1547
            ....|..|    ::.||
  Fly  2798 RQALLLQE----QSAGD 2810

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 54..286 CDD:459653 343/1837 (19%)
EGF_Lam 287..343 CDD:238012 15/90 (17%)
Laminin_EGF 355..415 CDD:395007 16/59 (27%)
Laminin_EGF 418..475 CDD:395007 17/56 (30%)
EGF_Lam 477..526 CDD:238012 15/145 (10%)
EGF_Lam 529..567 CDD:214543 13/56 (23%)
EGF_Lam 789..834 CDD:214543 14/55 (25%)
Laminin_EGF 837..885 CDD:395007 14/55 (25%)
Laminin_EGF 883..930 CDD:395007 14/78 (18%)
Laminin_EGF 933..988 CDD:395007 19/68 (28%)
Laminin_EGF 991..1035 CDD:395007 14/60 (23%)
Laminin_EGF 1043..1091 CDD:395007 16/67 (24%)
Laminin_EGF 1094..1142 CDD:395007 11/74 (15%)
Laminin_EGF 1142..1190 CDD:395007 17/67 (25%)
Mplasa_alph_rch 1228..>1771 CDD:275316 70/378 (19%)
cc_DmLAMB1-like_C 1717..1786 CDD:411973
Megf8NP_609180.3 CUB 33..141 CDD:238001
NanM <210..455 CDD:442289
KELCH repeat 228..268 CDD:276965
KELCH repeat 370..420 CDD:276965
KELCH repeat 425..476 CDD:276965
NanM 431..>630 CDD:442289
KELCH repeat 480..540 CDD:276965
EGF_3 1186..1222 CDD:463759 7/35 (20%)
EGF_Lam 1257..1302 CDD:238012 16/60 (27%)
EGF_Lam 1304..1354 CDD:238012 19/61 (31%)
KELCH repeat 1585..1638 CDD:276965 4/52 (8%)
NanM 1596..1892 CDD:442289 40/300 (13%)
KELCH repeat 1642..1685 CDD:276965 7/47 (15%)
KELCH repeat 1760..1813 CDD:276965 8/52 (15%)
KELCH repeat 1817..1867 CDD:276965 9/49 (18%)
EGF_Lam 2299..2346 CDD:238012 9/53 (17%)
EGF_Lam 2422..2487 CDD:238012 18/68 (26%)
Blue background indicates that the domain is not in the aligned region.

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