Protein Alignment LanB1 and wb

DIOPT Version :10

• Sequence 1: NP_476618.1
• Gene: LanB1 / 34068
• FlyBaseID: FBgn0261800
• Length: 1788
• Species: Drosophila melanogaster
• Sequence 2: XP_061516340.1
• Gene: wb / 3291603
• VectorBaseID: AGAMI1_002052
• Length: 3300
• Species: Anopheles gambiae
• Alignment Length: 2184
• Identity: 529/2184 - (24%)
• Similarity: 819/2184 - (37%)
• Gaps: 614/2184 - (28%)

  Fly    26 RPPQHGRRDRPKYPPNKFIK----------THPCER-----SSCYPATGNLLIGRENRLTASSTC 75
            |..|..|..||::...:.:|          |...|:     |..:|:..|:.:  ...::.::||
Mosquito    84 RTRQIWRHHRPRHSGRQELKLLSGLTVSSATTDYEQQLPKASGLWPSFFNVAL--RATISVNATC 146

  Fly    76 GLHSPERFCILS----HLQDKKCFLCDTREETKHDPYKNHRIGQIIYKTKPGTNIPTWWQS---E 133
            |....|.:|.|:    ..:..:|.:||....   ||.|.|.|..|:    .|||  :||||   :
Mosquito   147 GQTGREEYCRLAEGAGRSRGSQCGICDANNP---DPEKRHPITNIV----DGTN--SWWQSPTLQ 202

  Fly   134 NGKEN--ATIQLDLEAEFHFTHLIITFTTFR------PAAMYIERSFDFGQTWHIYRYFAYD--- 187
            .|.:|  .||.|||...:.     |.|.|.|      |||..:|:|.| |:.:..::|||.|
Mosquito   203 KGAKNDRVTINLDLGQLYQ-----IVFFTMRAAISPLPAAWVLEKSMD-GRAYDAWQYFAADDTE 261

  Fly   188 CKESFPGVPT-----VLENITDVMCTSRYSNVEPSRNGEVIFRVLP--PNINVTDPYAEHVQNQL 245
            |:|.| |:|.     :.::.|:|:|::::|::||..|||:...::.  |:..:|.|   .:||..
Mosquito   262 CRERF-GLPAYTANYIFKSDTEVICSTQFSSLEPLENGEINLSIISGRPSEMITSP---ELQNFT 322

  Fly   246 KMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQCLPLDPAFSQADNE 310
            ....:||::.::..          ...::.:|.|.::.:.|.|.|.|||.:|..::   :..|||
Mosquito   323 LARYVRIRLLRMQS----------AEAQRSFYTIRSLRIGGRCFCSGHAGKCKTMN---NNIDNE 374

  Fly   311 DGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHFDEAV----- 370
            .     :|||.|||.|.||:.|...:|..|::.......|.|:||||:.||.||.:|:.|
Mosquito   375 P-----QCECVHNTCGANCDRCCPLYNQRPYRIGTPVAANKCEKCECHGHAKSCIYDKLVDEQHL 434

  Fly   371 -FTASGFVS-GGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSDDGICDS 433
             .:..|.:| ||||.||.|:|.|.:||.|:|.:||..::.......|.||:|...|:.  |.|
Mosquito   435 SLSIRGKMSGGGVCQNCTHHTTGVNCERCLPGYYRPMDRLPIHPEPCLPCNCTSPGAV--GEC-- 495

  Fly   434 LNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTLNNSGCVMRTGEC 498
                  ..:.|.|.|....||.:|.:|..|:..::      |..|.|:..|||:...|..|   |
Mosquito   496 ------SPIGGECRCLEGFTGAQCTECLPGHSGVR------CTRCDCDARGTLSGRECDER---C 545

  Fly   499 KCKKYVTGKDCNQCMPETYGLSESP-EGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQP 562
            .||.:|.|:.|::|....:.|.|.. :||..|          ||..:..:|.. .|:...|.:..
Mosquito   546 SCKAHVVGERCDRCDEGYFALDEDHIDGCLKC----------YCSGVGTKCSV-AHVENSSYTTL 599

  Fly   563 KQNYFIPLLPEVHEAEVVDECISYGANGNCSLVAETPDGSFTGIGFTRVPENSELVF------TV 621
            |......|....|.....|.                 |..|...|...:|| :|.|:      .:
Mosquito   600 KGWTVTNLAMSEHIVPTKDN-----------------DTGFLVFGMFEMPE-TEAVYWKAPEGYL 646

  Fly   622 GDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPD-----QVDP---------------EGGCGEL 666
            |::.||  |.:    |.|.:.||    || ||.|     .|.|               |....|.
Mosquito   647 GNLLRS--YGS----QLTFKMDW----IT-VRGDTSGKPTVGPSLILVGRNGMKIAYGEESYEET 700

  Fly   667 AAAT-------SSETRIPFSLPD----------------RSRQVVALN--EVCLEAGKVYKFRIY 706
            ..||       .|...:|.::.|                ||:.:..|.  ||.|..|..:..::.
Mosquito   701 GGATITVPLKEDSWYHVPRTVKDIITRLRRTEYHGDPVTRSQFMAVLTDVEVVLLRGTYHTDQVE 765

  Fly   707 FERKRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVLADIRKKDYEKYNCKSSL--YDMNYKSDP 769
            ...::.|:.|.:.:....|.:....|::....:|          |...:|:...  |...|::..
Mosquito   766 SVLEQADLFSGSHSTTDSSASSSGFIELCECPEG----------YRGTSCEQCAFGYVRIYETSV 820

  Fly   770 KCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYC-QCKPNVVGRQCDQCAPGTYGFG--- 830
            ..:.:...:.      .||||.:...     |:...|.| .|..|.||..|::|.||.||..
Mosquito   821 THERIGRCIP------CSMCNGHAAS-----CDLETGECGLCLHNTVGTNCERCLPGFYGNATLG 874

  Fly   831 -PEGCKAC-------------DCNSIGSKDKYCDLITGQCQCVPNTY-GRECNQCQPGYWNFP-- 878
             |:.||.|             :|.|.|......:.:..||   |..| |..|..|..||:..|
Mosquito   875 RPDDCKRCACPLESPSNNFSPNCQSRGGSSDPSEYVCTQC---PEGYTGDHCELCDDGYYGEPTV 936

  Fly   879 ---ECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVA 940
               :|..|.|  |...|:...|.||:|..:|.|:.|:.|..||:|.|    :.||.||.|.|..|
Mosquito   937 IGGQCLPCPC--HGGPCNAQTGECIECVGNTEGWRCERCKTGYWGVP----DDGCEPCSCSELGA 995

  Fly   941 SGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPDNGGTCSKCECSNNVDLYDTGNC 1005
            .    .:.|.:.|..    |.|:..|.|.||:.| |..:||.|.  .|..|.|:.|..:...  |
Mosquito   996 L----ENVCDVTTGQ----CICKPRYGGRRCDEC-DVGYGNLDL--DCPACACNVNGSVSTV--C 1047

  Fly  1006 DRQTGACLKCLYQTTGDHCELCKDGFFG--DALQQNCQQCECDFLGTNNTIAHCDRFTGQCPCLP 1068
            :..:|.| :|...|.|.||:.|::.|||  |.....|:.|.|...|:..  ..|::.||||.|.|
Mosquito  1048 NVVSGQC-ECNVGTEGIHCDRCREEFFGLSDEQPGACEGCNCHPKGSLG--QGCNQKTGQCHCKP 1109

  Fly  1069 NVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQCQ----- 1128
            |::|.:|:.|.:.:|.:.||.||.||:||..|:..|.|:.:||||.||.|..|.:|::|.
Mosquito  1110 NIEGRQCNLCRKGYWDLNSGNGCISCSCDTNGSELEGCDLHTGQCFCKTGVTGTSCDRCDVGFYG 1174

  Fly  1129 -----------------------------------------AHYWGNPNEK-CQPCECDQFGAAD 1151
                                                     |:.|||..:| |:.|.||..|:..
Mosquito  1175 FSAQGCKRCDVCSSAAYVCDPDTGRCICPANSHGPECRSCIANTWGNEFQKGCKHCACDIVGSIG 1239

  Fly  1152 FQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPC---------------------GECFNN 1195
            ..||||||.|.|.||..|.:|||||.||.| :|.|..|                     |:| ..
Mosquito  1240 QSCDRETGQCSCKEGYTGRQCNECALGYYG-YPTCHRCACDERGTLPSNNGTVFPCDRNGQC-QC 1302

  Fly  1196 WDLILSALEDATTATILRAKEIKQVGATGAY----TSEFSELDK-----KLQHIRNL-------- 1243
            .:::.....|...............|.|..:    .||.::.|.     :|...|||
Mosquito  1303 KEMVYGKRCDICRQGTFGLAAFHPEGCTRCFCFGRASECTQSDHSWGQVRLAGSRNLSVEYLERQ 1367

  Fly  1244 -------------LQNT-----SVSLVDIEKLD-------------YET-----------QSLRD 1266
                         |:.|     .|::..:..|:             |.|           |.|.|
Mosquito  1368 DGHTEVDYVVILQLEGTQMHREDVNITSMNNLELIPSSSGNVSIGAYATFRYPLYFQLPPQFLGD 1432

  Fly  1267 QLQASHGRL--------------------------SETEQNLD-DIYNSLSLSGVELESLQNHS- 1303
            : .||:|.|                          ..|.:||. |.|......|..:||   ||
Mosquito  1433 R-TASYGGLLNFTLITDGATINIPEPSLRQFPLVQLHTHENLVLDFYEQTIRYGQPVES---HSV 1493

  Fly  1304 RLVQQLSKELKENGIQLQESNIEGALNLTRHAYER-----------VSNLSTLKDEANELASNTD 1357
            ||:..|.:. ..:|.....:.:..||...||.:.|           ::|::.  |....:|...:
Mosquito  1494 RLLGSLWRN-HYDGAWANRTILMTALQNVRHIFVRGTTTMDFQQVVLTNVTL--DTGIFVAGAEN 1555

  Fly  1358 RNCKRVENLSNKIQAEADDLANNNKLIEDYRAELTSLTSQIPELNNQV-----CGKPG-----DP 1412
            .:...||..|  ...:...|:..|.....||..|..:..:...:::.:     ||..|     ||
Mosquito  1556 NHAYGVERCS--CTPKYSGLSCQNPGPGYYRHRLPIVDLEWATIDDMIGKVVPCGCNGRSEECDP 1618

  Fly  1413 CDSLC-------GGAGCGHCG-GFL---------------------------------------- 1429
            ...:|       ||..|..|. ||.
Mosquito  1619 ETGVCLNCRNNTGGEHCERCAEGFYGDPNLGQCSPCPCPETRKNFARGCTVRGSDVHCICKTGYT 1683

  Fly  1430 -----SCEHGAKTHSE------EALKVAKDAETA---------------ITSKK-DQADQ----- 1462
                 ||..|...|..      ||.:..::...:               ||.:| |:.:|
Mosquito  1684 GALCDSCMRGYFGHPHLDNGHCEACECNREGSMSDECDHFTGECHCRPGITGRKCDRCEQPKHIV 1748

  Fly  1463 -----------TIRALTQAKLNASEAYEKA----KRG----------FEQSERYLNQTNANIKLA 1502
                       ||..:...::.||...|:.    :.|          :|...|.|:...|.:..|
Mosquito  1749 QDYRCKICDNCTITLIDDFEILASRLAEETAHIDRNGIPAPWVKLTKYEAKTRKLSNRVARLLEA 1813

  Fly  1503 ENL---FIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQINRAVSSLKNVEAIIY 1564
            |::   |:|  :|.|..|.:.:...:..|| :|..|....|||:...:   ||....:.:.||
Mosquito  1814 EDMAKKFMA--DFAEPLTRNATRLTKRLQK-MDNRLTAREEEIDKCNE---RANDLFEEINAI-- 1870

  Fly  1565 RTKPDLDRVNNLQSIAN------------ATKEKADKILDSANSVVESLAAAD---ESQGKAKDA 1614
                |.|..|.:|.:.|            |.||..|.:.| ...:.|::...|   |...|..|.
Mosquito  1871 ----DGDLRNTIQILKNYGVGDHHIKLPLAVKEAKDLLAD-IRDLAEAVEFDDTVLECANKQFDH 1930

  Fly  1615 IQQANSNIELAGQDLE----KIDEETYSAEAPANNTAQQVEKLAKKVQKLQNNIMKNDRDAKEIT 1675
            ....:..:|...:.|:    :|::..:.|:...|.|. ||.:..::.:..|....|:...|:...
Mosquito  1931 WSNVSKKVERQARRLDDLKFEIEQIHHKADHLQNYTV-QVFRHVQETEVYQTTNQKHFDKARAAY 1994

  Fly  1676 KEAGSVKLEAMRARGEANNLQSATSATNQTLTDRASRSENARERAKQLLQRASKLTVDTNAKLKD 1740
            ::|...:.|.|:...  .|:.|.|..|.:.|.|...:.|......:.||...|..|.|...:...
Mosquito  1995 EKALEDEAEVMKLLD--TNIMSDTDVTLEQLGDNYDQLEKDNRTLQFLLDGLSDATEDLIREKSI 2057

  Fly  1741 LNDLQTVYLNKNQQLLRLQAEIGPLNKELNEHLIHIKER 1779
            |.:.|.....::.:.|:.:|:             |||.:
Mosquito  2058 LLETQIPQALRHAEQLKAKAD-------------HIKNK 2083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanB1	NP_476618.1	Laminin_N	54..286	CDD:459653	69/256 (27%)
		EGF_Lam	287..343	CDD:238012	21/55 (38%)
		Laminin_EGF	355..415	CDD:395007	26/66 (39%)
		Laminin_EGF	418..475	CDD:395007	13/56 (23%)
		EGF_Lam	477..526	CDD:238012	16/49 (33%)
		EGF_Lam	529..567	CDD:214543	7/37 (19%)
		EGF_Lam	789..834	CDD:214543	16/49 (33%)
		Laminin_EGF	837..885	CDD:395007	16/66 (24%)
		Laminin_EGF	883..930	CDD:395007	16/46 (35%)
		Laminin_EGF	933..988	CDD:395007	17/54 (31%)
		Laminin_EGF	991..1035	CDD:395007	15/45 (33%)
		Laminin_EGF	1043..1091	CDD:395007	17/47 (36%)
		Laminin_EGF	1094..1142	CDD:395007	22/94 (23%)
		Laminin_EGF	1142..1190	CDD:395007	26/68 (38%)
		Mplasa_alph_rch	1228..>1771	CDD:275316	146/773 (19%)
		cc_DmLAMB1-like_C	1717..1786	CDD:411973	12/63 (19%)
wb	XP_061516340.1	None