DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and Lama3

DIOPT Version :10

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_001380677.1 Gene:Lama3 / 307582 RGDID:628776 Length:3333 Species:Rattus norvegicus


Alignment Length:2644 Identity:562/2644 - (21%)
Similarity:852/2644 - (32%) Gaps:1153/2644 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LIVVIVLALLSWQWDPVDSQRPPQHGRRDRPKYPPNKFIKTHPCERSSCYPATGNLLIGRENRLT 70
            |:::::|..:|..|..| :|.|                    |..|.|.:|...||  .:..::.
  Rat    16 LVLLLLLLRMSPCWSVV-AQDP--------------------PAARLSLHPPYFNL--AQAAKIW 57

  Fly    71 ASSTCGLHS-------PERFCIL---------SH-LQDKKCFLCDTREETKHDPYKNHRIGQIIY 118
            |::|||...       ||.||.|         .| :|.:.|..|::.:..|..| ..|.|     
  Rat    58 ATATCGERGLDVSRPRPELFCKLVGGPTAPGSGHTIQGQFCDYCNSEDSRKAHP-AIHAI----- 116

  Fly   119 KTKPGTNIPTWWQS-------ENGKENATIQLDLEAEFHFTHLIITFTTF-RPAAMYIERSFDFG 175
               .|:.  .||||       :..|.|.|  |||...||..:::|.|... ||....:|||.|||
  Rat   117 ---DGSE--RWWQSPPLSSGTQYNKVNLT--LDLGQLFHVAYILIKFANSPRPDLWVLERSVDFG 174

  Fly   176 QTWHIYRYFAY---DCKESFPGVPTVLENITD-VMCTSRYSNVEPSRNGEVIFRVLPPNINVTDP 236
            .|:..::|||:   ||.:.|.....:.....| |:|.:.||.:.|..|||::..::...     |
  Rat   175 NTYSPWQYFAHSRGDCLQQFGQEANMAVTRDDQVLCVTEYSRIVPLENGEIVVSLINGR-----P 234

  Fly   237 YAEH------VQNQLKMTNLRIQMTKLHKLGDNLLDSRLENE----EKYYYGISNMVVRGSCSCY 291
            .|:|      ::...|.||:|::..:.:.|..:|: |:.|.:    .:|||.|.::.|.|.|.|.
  Rat   235 GAKHFAFSDTLREFTKATNIRLRFLRTNTLLGHLI-SKAERDPTVTRRYYYSIKDISVGGRCVCN 298

  Fly   292 GHASQCLPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCE 356
            |||..|        .|||.:...  ||:|.|:|.|..|..|...:|..||:||...:.|.|:.|.
  Rat   299 GHAEAC--------SADNPEKQF--RCKCQHHTCGDTCNRCCAGYNQRPWRPAAQDQHNECEACN 353

  Fly   357 CNDHAVSCHFDEAV------FTASG-FVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERV 414
            |:.|||.|::||||      ..:.| :..||||.:|.|||.|.:||:|...::|.....:.:...
  Rat   354 CHGHAVDCYYDEAVSRQQASLNSKGVYTGGGVCIDCQHNTAGVNCEKCAKGYFRPHGVPVEALHG 418

  Fly   415 CQPCDCDP-------QGSS----------------DDG--------------------------- 429
            |.||.|||       |||.                .||                           
  Rat   419 CIPCSCDPDRADECDQGSGRCHCKPNFSGDFCETCADGYYNFPFCLRIPVFPDYTLNPEDPMAGN 483

  Fly   430 --------------ICDS--------------LNELEEGAVA----------------------- 443
                          |||.              .:....|:.:                       
  Rat   484 IKGCDCNLEGVLPEICDDRGRCLCRPGVEGPRCDSCRSGSYSFPICQACQCSTSGSYPVPCDPET 548

  Fly   444 GACHCKAFVTGRRCNQCKDG--------------------------------------------Y 464
            |.|.|...||||||::|..|                                            |
  Rat   549 GQCECLPGVTGRRCDRCLSGAYDFPYCQGSSSVCDPAGTMDSSLGYCQCKLHVTSPTCSVCKPLY 613

  Fly   465 WNLQSDNPEGCEPCTCNPLGTLNNSG-CVMRTGECKCKKYVTGKDCNQCMPETYGLSESPE-GCS 527
            |:|..:||.||..|.|:..||::..| |....|:|.||.:|||..|:.|....:.|.:|.. ||.
  Rat   614 WDLAKENPRGCSECQCHEAGTVSGIGECGQEDGDCSCKAHVTGDACDTCADGYFSLEKSNYFGCQ 678

  Fly   528 LCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQN-YFIPLLPEVHEAEVVDECISYGANGN 591
            .|.||.||:....|...||:|:||.|:.|:.|.:|:.| ||    |::|..:...|. ..|.||.
  Rat   679 GCQCDIGGALTTMCSGPSGECQCREHIEGKQCQRPESNCYF----PDLHHMKYEVEG-GTGPNGR 738

  Fly   592 CSLVA----ETPDGSFTG-IGFTRVPENSELVFTVGDIPRSMPYDAVIRYQS------------- 638
            .....    |.|:.|:.| :..|.|....::..||.....|: :..::||.:             
  Rat   739 DLRFGFDPLEFPEFSWRGYVPMTSVQNEVKVRLTVRKSSLSL-FRIILRYINPGMEEVSGRITVY 802

  Fly   639 TSRG--------------DWENAFITL----------VRPD------QVD--------------- 658
            :|||              ..|.||:|:          :.|.      ||:               
  Rat   803 SSRGKSDASQSKEITFPPSKEPAFVTVPGNGFADPFSITPGTWIACIQVEGVLLDYLVLLPRDYY 867

  Fly   659 ------------------PEGGC-------------------------GE---LA---------- 667
                              |:..|                         ||   ||          
  Rat   868 EAFALQVPVTEPCAHTGSPQDNCLLYQHLPLTRFSCTLACEATHFLIDGERRPLAVRQPMPTHPA 932

  Fly   668 ----AATSSETRIPFSLPDRSRQVVALN-----------EVCLE------AGKV----YKFRI-- 705
                :.|..|..:...:|.....||.|.           :|.|:      ||:|    .|:.|  
  Rat   933 MVDLSGTEVELHLRLRVPQIGHYVVMLEYATEVDQLFVVDVNLKSPESALAGQVNIYSCKYSILC 997

  Fly   706 -----------------------------------------------YFERKRHDVDS------- 716
                                                           |...:.|.:.|       
  Rat   998 RSVVIDSLSRTAVYELLADADVQLKVHAARFLLHHICVIPAEEFSTEYLRPQVHCIASYGQSANP 1062

  Fly   717 ------------PTATIL---------------------VDSLTL-IPRIDVT------------ 735
                        |||.||                     .:.:|| .|:..||            
  Rat  1063 SASCVSVTHETPPTALILDATSGGHFSPLPHEPSSPADVTNGVTLKAPQNQVTLRGLIPHLGRHV 1127

  Fly   736 -------------------------------------------PIFQGSVLADIRKKDY------ 751
                                                       .|.:|.|..||.:.|.      
  Rat  1128 FVVHFYQAEHPGFPTEVVVDGGRRWSGSFRASFCPHLLGCQDQVISEGQVEFDISEADVAVTVKI 1192

  Fly   752 ----------------EKYNC---------KSSLY------DMNYKSDPK-----CQNLDNILSV 780
                            |.|:.         |||.:      |..| .||:     |:|....|..
  Rat  1193 PDGKSLTLVRVLVVPAEDYDYHILHRTSVDKSSEFISSCGGDSFY-IDPQAASGFCKNSARSLVA 1256

  Fly   781 FVHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVGRQCDQCAPGTYGF---------------- 829
            |.|:||..|.|:|.|:....|...||.|.|:|||:||||.:||.|.|||                
  Rat  1257 FYHNGAVPCECHPAGAAVHHCSPEGGQCPCRPNVIGRQCTRCATGYYGFPHCKPCNCGRRLCEEV 1321

  Fly   830 -----------GPE---------------GCKACDCNSIGSKD---KYCDLITGQCQCVPNTYGR 865
                       .|:               ||:.|:|:..|:.:   ..||..:|||:|.|...|:
  Rat  1322 TGKCLCPPNTVRPQCEVCEMNSFNFHPVAGCEVCNCSRKGTVEAAVSECDRDSGQCRCKPRVTGQ 1386

  Fly   866 ECNQCQPGYWNFPECRVCQCN---GHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYY----GNPL 923
            :|::|.||:::||||..|.||   .....|||..|.|: |:::..|..|..|.:|.:    .|| 
  Rat  1387 QCDKCAPGFYHFPECVPCSCNRDGTEPGVCDPGTGACM-CKENVEGPQCQFCREGSFYLDSANP- 1449

  Fly   924 FGSEIGCRPCRC---------------------------------------------------PE 937
                .||..|.|                                                   |.
  Rat  1450 ----EGCTRCFCFGVNTDCRSSHKRRAKFVDMMGWRLETADGVDVPVSFNPSSNSVVADLQELPS 1510

  Fly   938 TVAS----------------------------GL------------------------------- 943
            :|.|                            ||                               
  Rat  1511 SVHSASWVAPPSYLGDKVSSYGGYLTYQAKSFGLPGDMVLLEKQPDVQLIGQHMSIIHAEPSDPR 1575

  Fly   944 ----------------AHADGCSLDTRNNNM---------------------------------- 958
                            .||...:..:|...|                                  
  Rat  1576 PDRPHHGRVQVVEGNFRHAGNSAPVSREELMAVLSSLEGLHIRGLHFTETQRLTLGEVGLEEASD 1640

  Fly   959 -----------LCHCQEGYSGSRCEICADNFFGNPDN--GGTCSKCECSNNVDLYDTGNCDRQTG 1010
                       :|.|...|:|..|:.|...::.:..:  .|.|..|.|:.:     :..|...:|
  Rat  1641 TGSGPRAHLVEMCTCPPDYTGDSCQGCRPGYYRDIKSFPAGRCVPCNCNGH-----SNRCQDGSG 1700

  Fly  1011 ACLKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGTNNTIAHCDRFTGQCPCLPNVQGVRC 1075
            .|:.|.:.|.|:|||.|::|::|.|:..:|:.|.|         .|.:.|...|.    |.|   
  Rat  1701 VCINCQHNTAGEHCERCQEGYYGSAIHGSCRVCPC---------PHTNSFATGCA----VDG--- 1749

  Fly  1076 DQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQCQAHYWGNPNE--- 1137
                                    ||:         :|.||||:.|..|.:|...|:|||.:   
  Rat  1750 ------------------------GAV---------RCACKPGYTGAQCERCAPGYFGNPQKFGG 1781

  Fly  1138 KCQPCECD---QFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPC---------- 1189
            .||||.|:   |||.    ||..||:||..|...|....||        ..|..|          
  Rat  1782 SCQPCNCNSNGQFGT----CDPLTGDCVSQEPKDGSPAEEC--------DDCDSCVMTLLNDLVS 1834

  Fly  1190 -GECFNNWDLILSALEDATTAT---------ILRAKEIKQ--VGATGAYTSEFSELD---KKLQH 1239
             ||   ...|:.|.|:..:.:|         .::||:::.  :|...|.:|..|::|   |:|.|
  Rat  1835 MGE---ELRLVKSRLQGLSVSTGALEQIRHVEMQAKDLRNQLLGFRSAISSHGSKMDGLEKELSH 1896

  Fly  1240 IRNLLQNTSVSLVDIEKLDYETQSLRDQLQASHGRLSETEQNLDD-IYNSLSLSGVELESLQNHS 1303
                             |:.|.::|:::.|.:..:......|:|. |.|:..|.......:||..
  Rat  1897 -----------------LNQEFETLQEKAQVNSRKAQTLYNNIDQTIQNAKELDMKIKNIIQNVH 1944

  Fly  1304 RLVQQL---------------SKELKENGIQLQE---------------SNIEGALNLTR----- 1333
            .|::|:               |:||.|....|:|               ..:|..|.|.|     
  Rat  1945 ILLKQIARPGGEGMDLPVGDWSRELAEAQRMLRELRGRDFKKHLQEAEAQKMEAQLLLNRIRTWL 2009

  Fly  1334 --HAYERVSNLSTLKDEANELASN-------------------------------TDRNCKRVEN 1365
              |..|....|..::|..|:..:.                               ..|..|.:::
  Rat  2010 ESHQVENNGLLKNIRDSLNDYEAKLQDLRSVLQEAAAQGKQATGLNHENEGVLGAIQRQMKEMDS 2074

  Fly  1366 LSNKIQ---AEAD-DLANNNKLIE-------DYRAELTSLTSQIPELNNQVCGKPGDPCDSLCGG 1419
            |.|.:.   |.|| .|...|.|::       :|.:...:|.....|||:||              
  Rat  2075 LKNDLTEHLATADASLLQTNSLLQRMDTSQKEYESLAAALNGARQELNDQV-------------- 2125

  Fly  1420 AGCGHCGGFLSCEHGAKTHSEEALKVAKDAETAITSKKDQADQTIRALTQAKLNASEAYEKAKRG 1484
            ......||.......|:.|::...::||..|.  ..:....|:.:|    ..::|:.|||..   
  Rat  2126 RELSRSGGKAPLVAEAEKHAQSLQELAKQLEE--IKRNTSGDELVR----CAVDAATAYESI--- 2181

  Fly  1485 FEQSERYLNQTNANIKLAENLFIALNNFQENKTASPSES-------KELAQ--KTLDLDLKLEPE 1540
                      .|| |:.||:        ...|.||.|||       ::|.:  |||..|    .|
  Rat  2182 ----------LNA-IRAAED--------AAGKAASASESAFQTVIKEDLPRRAKTLSSD----SE 2223

  Fly  1541 EI--------ETLGDQINRAVSSLKN-----------VEAIIYRTKPDLDRV--NNLQSIANATK 1584
            |:        :.|..:||.|::||:.           ::|.:...:.||..:  .::.|:.:..|
  Rat  2224 ELLNEAKMTRKRLQQEINPALNSLQQTLKTVSVQKDLLDANVTAVRNDLRGIQRGDIDSVVSGAK 2288

  Fly  1585 EKADKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDLEKIDEETYSAEAPANNTAQQ 1649
            ....|.....:.|::.|:......|:.||:......      :|..|       |...|||:   
  Rat  2289 SMVRKANGITSEVLDGLSPIQTDLGRIKDSYGSTRH------EDFNK-------ALIDANNS--- 2337

  Fly  1650 VEKLAKKVQKLQNNIMKNDRDAKEITKEAGSVKLEAMRARGEANNLQSATSATNQTLTDRASRSE 1714
            |:||.||:..|                   .||:|::                ||.|....:.|:
  Rat  2338 VKKLTKKLPDL-------------------FVKIESI----------------NQQLLPLGNISD 2367

  Fly  1715 NARERAKQLLQR----ASKLTVDT--NAKL-------KDLNDLQ 1745
            |. :|.::|:|:    |:|:.:..  |.|.       .||.||:
  Rat  2368 NV-DRIRELIQQARDAANKVAIPMRFNGKSGVEVRLPNDLEDLK 2410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 54..286 CDD:459653 75/270 (28%)
EGF_Lam 287..343 CDD:238012 20/55 (36%)
Laminin_EGF 355..415 CDD:395007 24/66 (36%)
Laminin_EGF 418..475 CDD:395007 29/201 (14%)
EGF_Lam 477..526 CDD:238012 17/50 (34%)
EGF_Lam 529..567 CDD:214543 16/38 (42%)
EGF_Lam 789..834 CDD:214543 23/86 (27%)
Laminin_EGF 837..885 CDD:395007 20/50 (40%)
Laminin_EGF 883..930 CDD:395007 15/53 (28%)
Laminin_EGF 933..988 CDD:395007 18/227 (8%)
Laminin_EGF 991..1035 CDD:395007 14/43 (33%)
Laminin_EGF 1043..1091 CDD:395007 7/47 (15%)
Laminin_EGF 1094..1142 CDD:395007 16/50 (32%)
Laminin_EGF 1142..1190 CDD:395007 17/61 (28%)
Mplasa_alph_rch 1228..>1771 CDD:275316 130/644 (20%)
cc_DmLAMB1-like_C 1717..1786 CDD:411973 11/42 (26%)
Lama3NP_001380677.1 LamNT 42..293 CDD:214532 76/271 (28%)
EGF_Lam 294..340 CDD:238012 20/55 (36%)
EGF_Lam 351..419 CDD:238012 24/67 (36%)
EGF_Lam 421..461 CDD:238012 10/39 (26%)
Laminin_EGF 487..534 CDD:395007 4/46 (9%)
EGF_Lam 531..573 CDD:238012 11/41 (27%)
Laminin_EGF 627..677 CDD:395007 17/49 (35%)
EGF_Lam 680..723 CDD:238012 19/46 (41%)
Laminin_EGF 1265..1313 CDD:395007 22/47 (47%)
EGF_Lam 1310..1353 CDD:238012 2/42 (5%)
EGF_Lam 1355..1400 CDD:238012 16/44 (36%)
EGF_Lam 1403..1453 CDD:238012 16/55 (29%)
Laminin_B 1517..1651 CDD:459652 6/133 (5%)
EGF_Lam 1685..1731 CDD:238012 15/50 (30%)
EGF_Lam 1733..1784 CDD:238012 21/99 (21%)
Laminin_I 1846..2103 CDD:310534 50/273 (18%)
Smc <1964..>2283 CDD:440809 72/364 (20%)
Laminin_II 2287..2415 CDD:368703 38/176 (22%)
LamG 2434..2569 CDD:214598
LamG 2601..2741 CDD:238058
LamG 2768..2900 CDD:238058
LamG 2992..3134 CDD:238058
LamG 3158..3309 CDD:238058
Blue background indicates that the domain is not in the aligned region.

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