DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and NTNG1

DIOPT Version :10

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_001106697.1 Gene:NTNG1 / 22854 HGNCID:23319 Length:539 Species:Homo sapiens


Alignment Length:523 Identity:145/523 - (27%)
Similarity:226/523 - (43%) Gaps:117/523 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 TCGLHSPERFCILSHLQDKKCFLCD-----TREETKHDPYKNHRIGQIIYKTKPGTNIPTWWQSE 133
            ||| ..||.||.:.:     .::|:     :..|..|.|       ::::..: |.:..|:|||.
Human    71 TCG-DPPETFCAMGN-----PYMCNNECDASTPELAHPP-------ELMFDFE-GRHPSTFWQSA 121

  Fly   134 NGKE-----NATIQLDLEAEFHFT-HLIITFTTFRPAAMYIERSFDFGQTWHIYRYFAYDCKESF 192
            ..||     ...|.|........| :::|||.:.||..|.:|:|.|:|:||..|:|:|.||.::|
Human   122 TWKEYPKPLQVNITLSWSKTIELTDNIVITFESGRPDQMILEKSLDYGRTWQPYQYYATDCLDAF 186

  Fly   193 PGVPTVLENIT-----DVMCTSRYSNVEPSRNGEVIFRVL--------PPNINVTDPYAE----- 239
            ...|..:::::     :::||..||....:.:..:.|.:.        |...|:...|.:     
Human   187 HMDPKSVKDLSQHTVLEIICTEEYSTGYTTNSKIIHFEIKDRFAFFAGPRLRNMASLYGQLDTTK 251

  Fly   240 HVQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQCLPLDPAF 304
            .:::...:|:|||::.: ..:|:..:|..  :..:|:|.||::.|||.|.|..||:.|:      
Human   252 KLRDFFTVTDLRIRLLR-PAVGEIFVDEL--HLARYFYAISDIKVRGRCKCNLHATVCV------ 307

  Fly   305 SQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPA----FGKKT-NAC-------KKCEC 357
              .||.    ...|||.|||.|.:|.:|:..:...||.|.    ..|.| |.|       ..|||
Human   308 --YDNS----KLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISSIGNCEC 366

  Fly   358 NDHAVSCHFDEAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDP 422
            ..|:..|.:.:.:.|.       :|.:|.|||||||||.|...::|:....:..|.||..|.|:|
Human   367 FGHSNRCSYIDLLNTV-------ICVSCKHNTRGQHCELCRLGYFRNASAQLDDENVCIECYCNP 424

  Fly   423 QGSSDDGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDG-YWNLQSDNPEGCEPCTC-NPLGT 485
            .||..|. |:.         :|.|.||...||.:|::|..| .|:.      ||:|..| |.|..
Human   425 LGSIHDR-CNG---------SGFCECKTGTTGPKCDECLPGNSWHY------GCQPNVCDNELLH 473

  Fly   486 LNNSGCVMRTGECKCKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRC 550
            ..|.|.......|.|....||..|.:                 ..|:..||    |...||| ..
Human   474 CQNGGTCHNNVRCLCPAAYTGILCEK-----------------LRCEEAGS----CGSDSGQ-GA 516

  Fly   551 RPH 553
            .||
Human   517 PPH 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 54..286 CDD:459653 59/240 (25%)
EGF_Lam 287..343 CDD:238012 18/55 (33%)
Laminin_EGF 355..415 CDD:395007 20/59 (34%)
Laminin_EGF 418..475 CDD:395007 17/57 (30%)
EGF_Lam 477..526 CDD:238012 11/49 (22%)
EGF_Lam 529..567 CDD:214543 9/25 (36%)
EGF_Lam 789..834 CDD:214543
Laminin_EGF 837..885 CDD:395007
Laminin_EGF 883..930 CDD:395007
Laminin_EGF 933..988 CDD:395007
Laminin_EGF 991..1035 CDD:395007
Laminin_EGF 1043..1091 CDD:395007
Laminin_EGF 1094..1142 CDD:395007
Laminin_EGF 1142..1190 CDD:395007
Mplasa_alph_rch 1228..>1771 CDD:275316
cc_DmLAMB1-like_C 1717..1786 CDD:411973
NTNG1NP_001106697.1 Laminin_N 50..295 CDD:459653 59/240 (25%)
NGL discriminant loop I 80..91 2/15 (13%)
NGL discriminant loop II 208..214 2/5 (40%)
NGL discriminant loop III 273..275 0/1 (0%)
EGF_Lam 296..342 CDD:238012 19/57 (33%)
EGF_Lam 364..412 CDD:238012 19/54 (35%)
EGF_Lam 420..467 CDD:214543 20/62 (32%)
Blue background indicates that the domain is not in the aligned region.

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