Protein Alignment LanB1 and Ntn3

DIOPT Version :10

• Sequence 1: NP_476618.1
• Gene: LanB1 / 34068
• FlyBaseID: FBgn0261800
• Length: 1788
• Species: Drosophila melanogaster
• Sequence 2: NP_035077.1
• Gene: Ntn3 / 18209
• MGIID: 1341188
• Length: 580
• Species: Mus musculus
• Alignment Length: 680
• Identity: 181/680 - (26%)
• Similarity: 266/680 - (39%)
• Gaps: 193/680 - (28%)

  Fly    48 PC-----ERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQDKKCFLCDTREETKHDP 107
            ||     |..||.|...|..:|||  :.|||||| .|..|.|..|                  ||
Mouse    29 PCYDEAREPRSCIPGLVNAALGRE--VLASSTCG-RSANRVCDSS------------------DP 72

  Fly   108 YKNHRIGQIIYKTKPGTNIPTWWQS---ENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYIE 169
            .:.|...  :..:.|||..|..|:|   :....|.|:.:.|...|....:.:.|.:..|.::.:.
Mouse    73 QRAHSAD--LLTSAPGTASPLCWRSDLLQQAPFNVTLTVPLGKAFELVFVSLRFCSAPPTSVALL 135

  Fly   170 RSFDFGQTWHIYRYFAYDCKESFPGVPTVLENIT----DVMCTSRYSNVEPSRNGEVIFRV---L 227
            :|.|.|::|....:|:..|...:..:|...:..:    :.:|... ...:|...|.:.|.|   .
Mouse   136 KSQDHGRSWVPLGFFSSSCTLDYGRLPAPADGPSGPGPEALCFPA-PQAQPDGGGLLAFSVQDGS 199

  Fly   228 PPNINVTDPYAEHVQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYG 292
            |..:::.:  :..:|:.:..|::||.:|:....||. .|..:  ...|.|..:.:.|.|.|.|.|
Mouse   200 PQGLDLDN--SPVLQDWVTATDIRIVLTRPAIQGDT-RDGGV--TVPYSYSATELQVGGRCKCNG 259

  Fly   293 HASQCLPLDPAFSQADNEDGMVHGR--CECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKC 355
            |||:|| ||            .||.  |:|.|.|:|.:|..|:.|:.|.||:.|.|::.:||..|
Mouse   260 HASRCL-LD------------THGHLVCDCQHGTEGPDCSRCKPFYCDRPWQRATGQEAHACLAC 311

  Fly   356 ECNDHAVSCHFDEAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDC 420
            .||.||..|.|:..::..||..|||||.||.|||.|:||..|...|||||.:.::..|.|:.|||
Mouse   312 SCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRVLSDRRACRACDC 376

  Fly   421 DPQGSSDDGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGT 485
            .|.|::.. .|:.        ..|.|.||..|||..||:|..|:  .||.:|  ..||...|:
Mouse   377 HPVGAAGK-TCNQ--------TTGQCPCKDGVTGLTCNRCAPGF--QQSRSP--VAPCVKTPV-- 426

  Fly   486 LNNSGCVMRTGECKCKKYVTGKDC-NQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCR 549
                     .|..:....|..:|| :.|.|                  |.|||.     ||.:..
Mouse   427 ---------PGPTEESSPVEPQDCESHCRP------------------ARGSYR-----ISLKKF 459

  Fly   550 CRPHMTGRSCSQPKQNYFIPLLPEVHEAEVVDECISYGANGNCSLVAETPDGSFTGIGFTRVPEN 614
            ||            ::|.:.              ::.||.|...       ||     :||.|..
Mouse   460 CR------------KDYAVQ--------------VAVGARGEAR-------GS-----WTRFPVA 486

  Fly   615 SELVFTVGD--------------------IPRSMPYDAVIRY--------------------QST 639
            ...||..|:                    .||.:|..   ||                    .|.
Mouse   487 VLAVFRSGEERARRGSSALWVPTLDAACGCPRLLPGR---RYLLLGGGPGAAAGSTAGRGQGLSA 548

  Fly   640 SRGD----WENAFI-TLVRPDQVDPEGGCG 664
            :||.    |.:|:. .|.|..:.:..|.||
Mouse   549 ARGSLVLPWRDAWTRRLRRLQRRERRGRCG 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanB1	NP_476618.1	Laminin_N	54..286	CDD:459653	55/241 (23%)
		EGF_Lam	287..343	CDD:238012	23/57 (40%)
		Laminin_EGF	355..415	CDD:395007	29/59 (49%)
		Laminin_EGF	418..475	CDD:395007	20/56 (36%)
		EGF_Lam	477..526	CDD:238012	9/49 (18%)
		EGF_Lam	529..567	CDD:214543	8/37 (22%)
		EGF_Lam	789..834	CDD:214543
		Laminin_EGF	837..885	CDD:395007
		Laminin_EGF	883..930	CDD:395007
		Laminin_EGF	933..988	CDD:395007
		Laminin_EGF	991..1035	CDD:395007
		Laminin_EGF	1043..1091	CDD:395007
		Laminin_EGF	1094..1142	CDD:395007
		Laminin_EGF	1142..1190	CDD:395007
		Mplasa_alph_rch	1228..>1771	CDD:275316
		cc_DmLAMB1-like_C	1717..1786	CDD:411973
Ntn3	NP_035077.1	Laminin_N	34..253	CDD:470680	57/247 (23%)
		EGF_Lam	254..299	CDD:238012	23/57 (40%)
		Laminin_EGF	311..362	CDD:395007	27/50 (54%)
		EGF_Lam	373..422	CDD:238012	21/61 (34%)
		NTR_netrin-1_like	456..562	CDD:239634	24/146 (16%)
		Cell attachment site, atypical. /evidence=ECO:0000255	500..502		0/1 (0%)