DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and epi-1

DIOPT Version :10

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_001294008.1 Gene:epi-1 / 177956 WormBaseID:WBGene00001328 Length:3715 Species:Caenorhabditis elegans


Alignment Length:2814 Identity:555/2814 - (19%)
Similarity:867/2814 - (30%) Gaps:1254/2814 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 LLIGRENRLTASSTCG--LHSP--ERFCIL------------SHLQDKK---------------- 93
            :.|.....:||:||||  ...|  |.:|.|            |:..|::                
 Worm    35 ITISHRKPITATSTCGEIQGQPVTEIYCSLTGSTQYTPLNSYSYQDDEQQKSWSQYENPMVRGGH 99

  Fly    94 -CFLCDTREETKHDPYKNHRIGQIIYKTKPGTNIPTWWQS-------ENGKENATIQLDLEAEFH 150
             |..|:...|..| |..|         ...|.|  :||.|       ::.:.|.||  |||.|||
 Worm   100 GCGHCNAGNENSH-PAAN---------MVDGNN--SWWMSPPLSRGLQHNEVNITI--DLEQEFH 150

  Fly   151 FTHLIITFTTF-RPAAMYIERSFDFGQT---WHIYRYFAYDCKESFPGVPTV--LENITDVMCTS 209
            ..::.|..... ||.:..:|||.|.|:|   |..:...|.:|...| |:.::  :.....|.|.:
 Worm   151 VAYVWIQMANSPRPGSWVLERSTDHGKTYQPWFNFAENAAECMRRF-GMESLSPISEDDSVTCRT 214

  Fly   210 RYSNVEPSRNGEVIFRVL---PPNINVTDPYAEHVQNQLKMTNLRIQMTKLHKLGDNLLDSRLEN 271
            ..::::|..|.|::.|:|   |.:.....  :|.:||..:.||:|:::.....|..:|:|.   |
 Worm   215 DMASLQPLENAEMVIRILEHRPSSRQFAT--SEALQNFTRATNVRLRLLGTRTLQGHLMDM---N 274

  Fly   272 E-------EKYYYGISNMVVRGSCSCYGHASQCLPLDPAFSQADNEDGMVHGRCECTHNTKGMNC 329
            |       .:|:|.|..:::.|.|.|.|||..|..|:|     .....::   |.|.|||.|..|
 Worm   275 EWRDPTVTRRYFYAIKEIMIGGRCVCNGHAVTCDILEP-----QRPKSLL---CRCEHNTCGDMC 331

  Fly   330 EECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHFD-------EAVFTASGFVSGGVCDNCLH 387
            |.|...|....|:.|.......|:.|.|...:..|.:|       :::.:...:..||||.||..
 Worm   332 ERCCPGFVQKQWQAATAHNNFTCEACNCFGRSNECEYDAEVDLNKQSIDSQGNYEGGGVCKNCRE 396

  Fly   388 NTRGQHCEECMPYFYR-----------------DPEQ---------------------------- 407
            ||.|.:|.:|...::|                 ||::                            
 Worm   397 NTEGVNCNKCSFGYFRPEGVTWNEPQPCKVCDCDPDKHTGACAEETGKCECLPRFVGEDCDQCAS 461

  Fly   408 --------------------DI------------------------------------------- 409
                                |:                                           
 Worm   462 GYYDAPKCKPCECNVNGTIGDVCLPEDGQCPCKAGFGGTFCETCADGYTNVTAGCVECVCDATGS 526

  Fly   410 --------TSERVCQP---------------------CDCDPQGSSDDGICDSLNE---LEEG-- 440
                    |.:..|:|                     |:|||.| ::.|:||....   .:||  
 Worm   527 EHGNCSASTGQCECKPAYAGLSCDKCQVGYFGDDCKFCNCDPMG-TEGGVCDQTTGQCLCKEGFA 590

  Fly   441 ----------------------------------------------------------------- 440
                                                                             
 Worm   591 GDKCDRCDIAFYGYPNCKACACDGAGITSPECDATSGQCPCNGNFTGRTCDKCAAGFYNYPDCRG 655

  Fly   441 ---AVAGA--------------------------------------------------------- 445
               .::||                                                         
 Worm   656 CECLLSGAKGQTCDSNGQCYCKGNFEGERCDRCKPNFYNFPICEECNCNPSGVTRDFQGCDKVSP 720

  Fly   446 ---CHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTLNN-SGCVMRTGECKCKKYVTG 506
               |.|:..||||.|:|||..:|:||..:.:||..|.||..||::. :.|.::||:|.|||...|
 Worm   721 GELCSCRKHVTGRICDQCKPTFWDLQYHHEDGCRSCDCNVNGTISGLNTCDLKTGQCMCKKNADG 785

  Fly   507 KDCNQCMPETYGL-SESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQNYFIPL 570
            :.|:||....|.| |.:..||..|:||.||:....||:.||||:|||.:||..|.||.:|::.|.
 Worm   786 RRCDQCADGFYRLNSYNQMGCESCHCDIGGALRAECDITSGQCKCRPRVTGLRCDQPIENHYFPT 850

  Fly   571 L-----------------------PE--------------------------------------- 573
            |                       ||                                       
 Worm   851 LWHNQYEAEDAHTEDQKPVRFAVDPEQFADFSWRGYAVFSPIQDKILIDVDITKATVYRLLFRYR 915

  Fly   574 -------------------VHEAE------------------VVD-------------------- 581
                               .|:.|                  .||                    
 Worm   916 NPTSVPVTATVTINPRFTHTHDVEQTGKATFAPGDLPAMKEITVDGKPFVLNPGKWSLAISTKQR 980

  Fly   582 -------------------------ECISYGA-NGNCSLVAETP--------------------- 599
                                     .|:|:.. |..|..:...|                     
 Worm   981 LFLDYVVVLPAEYYEGTVLRQRAPQPCLSHSTKNTTCVDLIYPPIPSVSRQFVDMDKVPFNYINE 1045

  Fly   600 DGSFTGI----------------GFTRVPENSELVFTVGDIPRSMPYDAVIRYQSTSRGDWENAF 648
            ||:.|.:                .|.|..||..:|....|:|.:..|..|:.|.:....| .|..
 Worm  1046 DGTTTALEHVPVEILLSEITGPAAFVRADENPRVVEAKLDVPETGEYVIVLEYHNREETD-GNIG 1109

  Fly   649 ITLVRPDQVDPEGG-----------CGELAAATSSETRIPFSLPDRSRQVVALN----------- 691
            :.:.:.|:....|.           |.||   .|||..||:...::....|.||           
 Worm  1110 VGISQNDKEVLNGNAVIHHCPYATFCREL---VSSEGTIPYIPLEKGEATVRLNIKPNHEFGLAG 1171

  Fly   692 -----------------EVCLE------------------------------------------- 696
                             .||::                                           
 Worm  1172 VQLIKKSDFSSEYLQQVPVCIKKDARCVQQSYPPAADSVTTEAESGSNMDKSILGDKLPFPVSNS 1236

  Fly   697 -----------------AGKV-----YKFRIYF-------------------------------- 707
                             :|.|     |.|.:::                                
 Worm  1237 KEMRVVPLDDAQATVEISGVVPTRGHYMFMVHYFNPDNTPINIDVLIQNEHYFQGDSCNSFACYN 1301

  Fly   708 ----------------------------ERKRHDV------DSPTAT----------ILVDSLTL 728
                                        :::|.:|      |..|||          |.:||:|.
 Worm  1302 KYSSRFIFNASVPLAFCPSISGCRALIRDKERPEVIQFYMDDKYTATFYHNSSQKGPIYIDSITA 1366

  Fly   729 IP------------RIDVTPIFQGSVLADIRKKDYEKYN--CKSSLY----DMN----------- 764
            :|            .:|::..|......|..|...|..:  ||..::    |.|           
 Worm  1367 VPYNSYKDKLMEPLALDLSNEFLKECSEDNLKNHPESVSDFCKQKIFSLTTDFNAAALSCDCVAQ 1431

  Fly   765 -------------------------------YKSDPKC--------------------------Q 772
                                           |.:.|:|                          |
 Worm  1432 GSESFQCEQYGGQCKCKPGVIGRRCERCAPGYYNFPECIKCQCNAGQQCDERTGQCFCPPHVEGQ 1496

  Fly   773 NLDNILS-VFVHD---GASMCNCNPTGSL--SKVCESNGGYCQCKPNVVGRQCDQCAPGTYGFGP 831
            ..|..:| .|.:|   |...|.|:|.||.  :.||:...|.|.|:.::.|||||:|..|.||| |
 Worm  1497 TCDRCVSNAFGYDPLIGCQKCGCHPQGSEGGNLVCDPESGQCLCRESMGGRQCDRCLAGFYGF-P 1560

  Fly   832 EGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQPG----------------------- 873
            . |..|.||..|:.::.||....||:|..|.||..|..|:.|                       
 Worm  1561 H-CYGCSCNRAGTTEEICDATNAQCKCKENVYGGRCEACKAGTFDLSAENPLGCVNCFCFGVTDS 1624

  Fly   874 ----------------------------------------------------------------- 873
                                                                             
 Worm  1625 CRSSMYPVTIMSVDMSSFLTTDDNGMVDNKDDTVIYTSEETSPNSVYFNVPIEKKDYTTSYGLKL 1689

  Fly   874 -------------------------------YW---------------------NF--------- 877
                                           ||                     ||         
 Worm  1690 TFKLSTVPRGGRKSMNADADVRLTGANMTIEYWASEQPTNPEEQFTVKCKLVPENFLTAEGKTVT 1754

  Fly   878 --------------------------------------------------------------PEC 880
                                                                          |.|
 Worm  1755 REELMKVLHSLQNITLKASYFDHPKTSTLYEFGLEISEPNGVDSVIKASSVEQCQCPAPYTGPSC 1819

  Fly   881 RV-------------------CQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGS 926
            ::                   |:||||:|||||..|.|.||:.:|.|..|:.|.:|:|||...||
 Worm  1820 QLCASGYHRVQSGSFLGACVPCECNGHSATCDPDTGICTDCEHNTNGDHCEFCNEGHYGNATNGS 1884

  Fly   927 EIGCRPCRCPETVASGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPD-NGGTCSK 990
            ...|..|.||....:..|.:  |.:......:.|:|:.||:|.||:.||..|||:|. :|.:||.
 Worm  1885 PYDCMACACPFAPTNNFAKS--CDVSEEGQLLQCNCKPGYTGDRCDRCASGFFGHPQISGESCSP 1947

  Fly   991 CECSNNVDLYDTGNCDRQTGACLKCLYQTTGDHCELCKDGFFGDAL-QQNCQQCECDFLGTNNTI 1054
            |:|:.|.:|.|:.:|...:|.|..|...|.|.|||.|...|:|||: .:||..|||...|:.   
 Worm  1948 CQCNGNNNLTDSRSCHPNSGDCYLCEQNTDGRHCESCAAWFYGDAVTAKNCSSCECSQCGSQ--- 2009

  Fly  1055 AHCDRFTGQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGF 1119
             :||..:|.|.|..||:|..||:|..:||..:..:||:.|:|. ..|.:.|||...|||.|:||.
 Worm  2010 -YCDNKSGGCECKINVEGDSCDRCKPDHWGFSKCQGCQGCHCG-TAAFNTQCNVENGQCTCRPGA 2072

  Fly  1120 GGRACNQCQAHYWGNPNEKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFP 1184
            .|..|..|:..||......|..|:|:...:....||..||.|.|.||..|.:|::|...|: :.|
 Worm  2073 TGMRCEHCEHGYWNYGEHGCDKCDCEADLSMGTVCDVRTGQCHCQEGATGSRCDQCLPSYL-RIP 2136

  Fly  1185 --HCSPCGECFNNW-----------DLILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKK 1236
              .|..|.||.::.           |::.:|:.:.::|||:.|:..:.       ..||::::: 
 Worm  2137 TYGCRRCDECVHHLIGDVDNLELEIDVLGTAIANISSATIVGARLARN-------KKEFNDINE- 2193

  Fly  1237 LQHIRNLLQNTSVSLVDI--EKLDYETQSLRDQLQASHGRLSETEQNLDDIYNSLSLSGVE-LES 1298
               |..:|.:...|..::  :..|..|.|  .|:|....|.....||......:::|:|.| |:.
 Worm  2194 ---ITKMLNDEENSFGNVFGDAQDILTNS--TQIQNKLVRTKTHSQNSVSSAKNITLNGTEFLQE 2253

  Fly  1299 LQNHSRLVQQLSKELKENGIQLQESNIEGALN----LTRHAYERVSNLSTLK-DEANELASNTDR 1358
            :...::..:|..:.|.|..:.:..|:  .|:|    |.:.|.|.:..|.... |:..|.|.... 
 Worm  2254 VMKRAQRARQSVRSLAEIALAIGSSS--KAVNVDPRLLKEAEETLMTLEAASADQYPEKAQTVP- 2315

  Fly  1359 NCKRVENLSNKIQAEADDLANNNKLIEDYRAELTSLTSQIPELNNQVCGKPGDPCDSLCGGAGCG 1423
              .::|.:..|||.|.:.|   :|..|.:.|:                                 
 Worm  2316 --GKLEEIQKKIQEETEKL---DKQKETFEAQ--------------------------------- 2342

  Fly  1424 HCGGFLSCEHGAKTHSEEALKVAKDAETAITSKKDQADQT-----------IRALTQAKLNASEA 1477
                        |..:||.......|:..:...|.:||::           :..|..|..:..|.
 Worm  2343 ------------KKRAEELAAYLNSAQQLLKESKSKADKSNNIAKMLQLTKVENLVAAITDDLER 2395

  Fly  1478 YEKAKRGFEQSERYLNQTNANIK-LAENLFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEE 1541
            .|.||..|::....:.....|:| ..|.:..|:....|.:. ..:|:.|.|:|.:..|.|     
 Worm  2396 VEAAKGEFQKLNVAIGNITENLKDKREEMTHAVTTLNETRN-DVAEALEAAKKRVRRDEK----- 2454

  Fly  1542 IETLGDQINRAVSSLKNVEAIIYRTKPDLDRVNNLQSI--ANA------TKEKADKILDSANSVV 1598
              ::..|:..|.:...:::|...|...|.::.|..|::  |||      |.:.|...:|:|...:
 Worm  2455 --SVDMQLVNAKAHELHLQATTLRQTFDNNKDNTDQAVEAANAFSNLTDTLKNAKAQIDNAYEAL 2517

  Fly  1599 ESLAAADESQGKAKD----------------AIQQANSNIELAGQDLEKIDE---------ETYS 1638
            .:..|..||...|:|                .:.|.....|...:.||::.|         |...
 Worm  2518 SAEPAFAESVQNARDKPFPDETKEKIDALSKTVSQDLKETEKLKKQLEQLTELSEKLRKRKEAVK 2582

  Fly  1639 AEAP--ANNTAQQVEKLAKKVQKLQNNIMKNDRD-----------AKEITKEAGSVKLEAMR-AR 1689
            |..|  :.||...:::..::|:||:..|..|..:           |:|||::|.|. :|.:| ||
 Worm  2583 AGIPKYSKNTLDSIDEKVQEVEKLKAEIDANIEETRAKISEIAGKAEEITEKANSA-MEGIRLAR 2646

  Fly  1690 -----------------GEANNLQSATSATNQTLTDRASRSEN----ARERAKQL-----LQRAS 1728
                             .|...|.||.||...:::|:.|:.:.    ||:.|.::     .::.|
 Worm  2647 RNSVQLNKLAPVIVSKFEELKKLSSARSAKVDSVSDKVSQIKEMIAVARDAANRIKLGAHFEKGS 2711

  Fly  1729 KLTVDTNAKLKDLNDLQTV 1747
            .|         |||..|.|
 Worm  2712 SL---------DLNIPQRV 2721

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 54..286 CDD:459653 69/280 (25%)
EGF_Lam 287..343 CDD:238012 19/55 (35%)
Laminin_EGF 355..415 CDD:395007 20/182 (11%)
Laminin_EGF 418..475 CDD:395007 25/189 (13%)
EGF_Lam 477..526 CDD:238012 19/50 (38%)
EGF_Lam 529..567 CDD:214543 20/37 (54%)
EGF_Lam 789..834 CDD:214543 21/46 (46%)
Laminin_EGF 837..885 CDD:395007 22/277 (8%)
Laminin_EGF 883..930 CDD:395007 24/46 (52%)
Laminin_EGF 933..988 CDD:395007 19/55 (35%)
Laminin_EGF 991..1035 CDD:395007 17/43 (40%)
Laminin_EGF 1043..1091 CDD:395007 17/47 (36%)
Laminin_EGF 1094..1142 CDD:395007 18/47 (38%)
Laminin_EGF 1142..1190 CDD:395007 16/49 (33%)
Mplasa_alph_rch 1228..>1771 CDD:275316 126/613 (21%)
cc_DmLAMB1-like_C 1717..1786 CDD:411973 9/36 (25%)
epi-1NP_001294008.1 LamNT 24..296 CDD:214532 69/280 (25%)
EGF_Lam 297..345 CDD:238012 19/55 (35%)
Laminin_EGF 427..474 CDD:395007 2/46 (4%)
EGF_Lam 471..520 CDD:238012 1/48 (2%)
EGF_Lam 519..564 CDD:214543 3/44 (7%)
Laminin_EGF 564..612 CDD:395007 10/48 (21%)
Laminin_EGF 610..658 CDD:395007 0/47 (0%)
Laminin_EGF 656..703 CDD:395007 2/46 (4%)
Laminin_EGF 701..753 CDD:395007 13/51 (25%)
Laminin_EGF 756..806 CDD:395007 19/49 (39%)
EGF_Lam 808..854 CDD:238012 22/45 (49%)
CBM6-CBM35-CBM36_like 855..988 CDD:271143 6/132 (5%)
Laminin_EGF 1426..1474 CDD:395007 3/47 (6%)
EGF_Lam 1472..1515 CDD:238012 6/42 (14%)
Laminin_EGF 1517..1567 CDD:395007 23/51 (45%)
Laminin_EGF 1565..1613 CDD:395007 15/47 (32%)
LamB 1669..1793 CDD:214597 4/123 (3%)
EGF_Lam 1840..1883 CDD:238012 22/42 (52%)
Laminin_EGF 1891..1945 CDD:395007 19/55 (35%)
EGF_Lam 1947..1998 CDD:238012 19/50 (38%)
EGF_Lam 2001..2045 CDD:214543 17/47 (36%)
EGF_Lam 2048..2092 CDD:214543 17/44 (39%)
EGF_Lam 2095..2140 CDD:214543 15/45 (33%)
PTZ00121 <2289..2917 CDD:173412 102/502 (20%)
Laminin_II 2589..2730 CDD:368703 35/143 (24%)
LamG 2704..2875 CDD:238058 7/27 (26%)
LamG 2909..3057 CDD:238058
LamG 3353..3510 CDD:238058
LamG 3532..3682 CDD:238058
Blue background indicates that the domain is not in the aligned region.

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