DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and Lamb3

DIOPT Version :10

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_032510.2 Gene:Lamb3 / 16780 MGIID:99915 Length:1168 Species:Mus musculus


Alignment Length:1796 Identity:389/1796 - (21%)
Similarity:590/1796 - (32%) Gaps:707/1796 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 CERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQDKKCFLCDTREETKHDPYKNHRI 113
            |.|.:|||..|:|||||...|.|||||||..||.:|........||..||:|....   |.:||:
Mouse    21 CSRGACYPPVGDLLIGRTQLLRASSTCGLTKPETYCTQYGQWQMKCCKCDSRLPRN---YNSHRV 82

  Fly   114 GQIIYKTKPGTNIPTWWQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYIERSFDFGQTW 178
            ..:...:.|    ..||||:|.....::||||:.......:::.|....||.|.||||.|||:||
Mouse    83 ENVASSSGP----MRWWQSQNDVSPVSLQLDLDKRMQLQDIMMDFKGLTPAGMLIERSSDFGKTW 143

  Fly   179 HIYRYFAYDCKESFP----GVPTVLENITDVMCTSRYSNVEPS---RNGEVIFRVLPPNINVTDP 236
            .:|:|.|.||..:||    |.|   :|..||.|  |..:..|:   ..|:|...::.....:...
Mouse   144 RVYQYLATDCASTFPQVHQGQP---KNWQDVRC--RPLSQRPNGHLTGGKVQLNLMDLASAIPAS 203

  Fly   237 YAEHVQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQCLPLD 301
            .::.:|....:||||:..|||..     :..|.......|:.:|.:.::|||.|:|||.:|.|  
Mouse   204 QSKKIQELGDITNLRVNFTKLAP-----VPQRGSYPPSAYFAVSQLRLQGSCFCHGHADRCAP-- 261

  Fly   302 PAFSQADNEDG-----MVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHA 361
                   |..|     .|:..|.|.|||.|.||:.|..|:|:.||:||.|:.|:.|::|:||.|:
Mouse   262 -------NPGGSTTAVQVNNVCVCQHNTAGPNCDRCAPFYNNRPWRPAEGQDTHECQRCDCNGHS 319

  Fly   362 VSCHFDEAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSS 426
            .:||||.|||.||...:|||||||..:|.|::||.|..:::|:..........|.||:|||.|:.
Mouse   320 ETCHFDPAVFAASQGTNGGVCDNCRDHTEGKNCERCQLHYFRNRRPSAPIHETCIPCECDPDGAV 384

  Fly   427 DDGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTLNNSGC 491
            ....||.|                                                         
Mouse   385 QGAPCDRL--------------------------------------------------------- 392

  Fly   492 VMRTGECKCKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTG 556
               ||:|.||:||.|:.|:.|.|                                          
Mouse   393 ---TGQCVCKEYVQGERCDLCKP------------------------------------------ 412

  Fly   557 RSCSQPKQNYFIPLLPEVHEAEVVDECISYGANGNCSLVAETPDGSFTGIGFTRVPENSELVFTV 621
                                                         .|||:.|.            
Mouse   413 ---------------------------------------------GFTGLTFA------------ 420

  Fly   622 GDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPFSLPDRSRQ 686
                                                                             
Mouse   421 ----------------------------------------------------------------- 420

  Fly   687 VVALNEVCLEAGKVYKFRIYFERKRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVLADIRKKDY 751
                                                                             
Mouse   421 ----------------------------------------------------------------- 420

  Fly   752 EKYNCKSSLYDMNYKSDPKCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVG 816
                                                                             
Mouse   421 ----------------------------------------------------------------- 420

  Fly   817 RQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQPGYWNFPECR 881
                         .|:||.||||:.:|::                                    
Mouse   421 -------------NPKGCHACDCSILGAR------------------------------------ 436

  Fly   882 VCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVASGLAHA 946
                                                                             
Mouse   437 ----------------------------------------------------------------- 436

  Fly   947 DGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPDNGGTCSKCECSNNVDLYDTGNCDRQTGA 1011
                                                                             
Mouse   437 ----------------------------------------------------------------- 436

  Fly  1012 CLKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGTNNTIAHCDRFTGQCPCLPNVQGVRCD 1076
                            ||                         ..|:..||:|.|||||.|.:||
Mouse   437 ----------------KD-------------------------MPCEEETGRCLCLPNVVGPKCD 460

  Fly  1077 QCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACN-----QCQAHYWGNPN 1136
            |||.:|||:|||.|||.|.|||..:|..|||.:||||.|:.||||..|:     ||....:|:..
Mouse   461 QCAPSHWKLASGLGCEPCACDPRNSLSSQCNQFTGQCPCREGFGGLTCSSAAIRQCPDQTYGHVA 525

  Fly  1137 EKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGECFNNWDLILS 1201
            ..|:.|:||..|.....||:.:|.|:|..|..|.:|::|.||:..::|.|..|..||..:|..|.
Mouse   526 TGCRACDCDFRGTEGPGCDKASGRCLCRPGFTGPRCDQCQRGHCDRYPVCVACHSCFQAYDTDLQ 590

  Fly  1202 ALEDATTATILR-AKEIKQVGATG----AYTSEFSELDKKLQHIRNLLQNTSVSLVDIEKLDYET 1261
              |.|.....|| |.|....| ||    ...|...:...|::.||.:|:.|||:..|:.::....
Mouse   591 --EQARRLHSLRNATEGLWTG-TGLEDHGLASRLLDAKSKIEQIRQILEGTSVTEQDVAQVANGI 652

  Fly  1262 QSLRDQLQASHGRLSETEQNLDDIYNSLSLSGVELESL-QNHSRLVQQLSKELKENGIQLQESNI 1325
            .|:|..||.....| ..|:.::      |.|| :|.:| ::.|||: .:.:..||...:|...:.
Mouse   653 LSIRRTLQGLPLDL-PLEEEME------SFSG-DLGNLDRSFSRLL-LMYRSKKEQFEKLSSEDP 708

  Fly  1326 EGALNLTRHAYERVSNLSTLKDEANELASNTDRNCKRVENLSNKIQAEADDLANNNKLIEDYRAE 1390
            .||..:...|||:.|..:....:::.|.|....:.:..|.|    :.:|.........:...|.|
Mouse   709 SGAFRMLTMAYEQSSRAAQQVSDSSSLLSQLRDSRREAEGL----ERQAGGGGTGGAQLMALRLE 769

  Fly  1391 LTSLTSQIPELNNQVCGK-------PGDPCDSLC---GGAGCG-HCGGFLSCEHGAKTHSEEALK 1444
            :.||....|.: |::||:       |||....||   .|..|| ||.|.|....||   ...|.:
Mouse   770 MASLPDLTPTI-NKLCGRSRQTACTPGDCPGELCPQDNGTACGSHCRGALPRAKGA---FHMAGR 830

  Fly  1445 VAKDAETAITSKKDQADQTIRALTQAKLNASEAYEKAKRGFEQSERYLNQTNANIKLAEN----- 1504
            ||:.... ..::..|..|.|||          |.|.|.|....::|...|.:.:..|.|.     
Mouse   831 VAEQLRN-FNTQLQQTRQMIRA----------AEEAASRVQADAQRLETQVSTSRLLMEEDVQRT 884

  Fly  1505 --LFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQINRAVSSLKNVEAIIYRTK 1567
              |...:..|..:.....:..:::::..|.|.|..:...:.....:|....:.|.||::::.:||
Mouse   885 RLLIQQVRGFLTDPDTDAATIQQVSEAVLALWLPTDSATVLRKMKEIQAIAARLPNVDSVLSQTK 949

  Fly  1568 PDLDRVNNLQSIANATKEKADKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDLEKI 1632
            .|:.|...||:.|...:.:|..:....:.||.:|     .||..  |:|:|...::..|:.|..|
Mouse   950 QDIARARRLQAEAEQARSRAHAVEGQVDDVVGNL-----RQGTV--ALQEAQDTMQGTGRSLRLI 1007

  Fly  1633 DEETYSAEAPANNTAQQV----EKLAKKVQKLQNNIMKNDRDAKEITKEAGSVKLEAMRAR---- 1689
            .|..        ...|||    |:|.|.:::..:.....   .||:.::|...:.:||:||    
Mouse  1008 QERV--------GEVQQVLVPAERLVKGMKEQMSGFWAR---MKELRRQAQEEQAQAMQARQLAE 1061

  Fly  1690 ---GEANNLQSATSATNQTLT---DRASRSENARERAKQLL---QRASKLTVDTNAKLKDLNDLQ 1745
               .:|.|.|.......|..|   ||..:|....|:..::|   ..|.:|..:|...:..:.|::
Mouse  1062 GASQQAMNAQEGFKRLKQKYTELKDRLGQSPVLGEQGNRILSIKMEAEELFGETMEMMDKMKDME 1126

  Fly  1746 TVYLNKNQQLLRLQAEIGPLNKELNEHLIHIKERGSHYRQC 1786
            :..|..:|.::...|::..|.|.:.:...:|..|..:|..|
Mouse  1127 SELLRGSQAIMLRSADLSGLEKRVEQIRSYINGRVLYYATC 1167

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 54..286 CDD:459653 79/238 (33%)
EGF_Lam 287..343 CDD:238012 24/60 (40%)
Laminin_EGF 355..415 CDD:395007 26/59 (44%)
Laminin_EGF 418..475 CDD:395007 8/56 (14%)
EGF_Lam 477..526 CDD:238012 11/48 (23%)
EGF_Lam 529..567 CDD:214543 0/37 (0%)
EGF_Lam 789..834 CDD:214543 1/44 (2%)
Laminin_EGF 837..885 CDD:395007 4/47 (9%)
Laminin_EGF 883..930 CDD:395007 0/46 (0%)
Laminin_EGF 933..988 CDD:395007 0/54 (0%)
Laminin_EGF 991..1035 CDD:395007 2/43 (5%)
Laminin_EGF 1043..1091 CDD:395007 21/47 (45%)
Laminin_EGF 1094..1142 CDD:395007 22/52 (42%)
Laminin_EGF 1142..1190 CDD:395007 17/47 (36%)
Mplasa_alph_rch 1228..>1771 CDD:275316 136/578 (24%)
cc_DmLAMB1-like_C 1717..1786 CDD:411973 14/71 (20%)
Lamb3NP_032510.2 Laminin_N 20..248 CDD:470680 81/243 (33%)
EGF_Lam 249..301 CDD:238012 24/60 (40%)
Laminin_EGF 313..367 CDD:395007 26/53 (49%)
Laminin_EGF 376..425 CDD:395007 24/415 (6%)
Laminin_EGF 428..475 CDD:395007 27/253 (11%)
Laminin_EGF 478..531 CDD:395007 22/52 (42%)
EGF_Lam 530..579 CDD:238012 17/48 (35%)
Domain II 576..781 56/221 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 723..760 6/40 (15%)
Domain alpha 782..812 9/29 (31%)
Domain I 813..1168 87/387 (22%)
SMC_prok_B <830..1161 CDD:274008 77/359 (21%)
cc_LAMB_C 1098..1168 CDD:424069 14/70 (20%)

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