DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and Lamb2

DIOPT Version :10

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_032509.2 Gene:Lamb2 / 16779 MGIID:99916 Length:1799 Species:Mus musculus


Alignment Length:1802 Identity:746/1802 - (41%)
Similarity:997/1802 - (55%) Gaps:112/1802 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 CERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQD-KKCFLCDTREE-TKHDPYKNH 111
            |.|.|||||||:||:||.:|||||||||||||:.:||:||||| |||||||:|.. :..|...:|
Mouse    45 CSRGSCYPATGDLLVGRADRLTASSTCGLHSPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPNSH 109

  Fly   112 RIGQIIYKTKPGTNIPTWWQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYIERSFDFGQ 176
            ||..::....|... ..|||||||....||||||||||||||||:||.|||||||.:|||.|||:
Mouse   110 RIQNVVTSFAPQRR-TAWWQSENGVPMVTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGR 173

  Fly   177 TWHIYRYFAYDCKESFPGVPTV-LENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTDPYAEH 240
            |||:||||:|||...|||:|.. .....||:|.||||.:|||..||||:|||.|.|.:.|||:..
Mouse   174 TWHVYRYFSYDCGADFPGIPLAPPRRWDDVVCESRYSEIEPSTEGEVIYRVLDPAIPIPDPYSSR 238

  Fly   241 VQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQCLPLDPAFS 305
            :||.||:||||:.:|:||.|||||||.|.|..|||||.:..:|:||:|.||||||||.|...|.:
Mouse   239 IQNLLKITNLRVNLTRLHTLGDNLLDPRREIREKYYYALYELVIRGNCFCYGHASQCAPAPGAPA 303

  Fly   306 QADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHFDEAV 370
            .|   :|||||.|.|.|||:|:|||:|:||:.||||.||....|:||:|||||.|..|||||.||
Mouse   304 HA---EGMVHGACICKHNTRGLNCEQCQDFYQDLPWHPAEDGHTHACRKCECNGHTHSCHFDMAV 365

  Fly   371 FTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSDDGICDSLN 435
            :.|||.|||||||.|.|||.|:|||.|.|:|||||.:|:....||:||||||.||.|.|.|||.:
Mouse   366 YLASGNVSGGVCDGCQHNTAGRHCEFCRPFFYRDPTKDMRDPAVCRPCDCDPMGSQDGGRCDSHD 430

  Fly   436 ELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTL-NNSGCVMRTGECK 499
            :...|.|:|.|.||..|.|.||.||:||::.|.:.:|.||:.|.||..||: .:|.|...:|.|.
Mouse   431 DPVLGLVSGQCRCKEHVVGTRCQQCRDGFFGLSASDPRGCQRCQCNSRGTVPGSSPCDSSSGTCF 495

  Fly   500 CKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQ 564
            ||:.|||..|::|:|..:|||....||..|:||.||:.|..||..:||||||.||.||.|.|.:.
Mouse   496 CKRLVTGHGCDRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEATGQCRCRQHMIGRRCEQVQP 560

  Fly   565 NYFIPLLP----EVHEA-----EVVDECISYGANGNCSLVAETPDGSFTGIGFTRVPENSELVFT 620
            .||.|.|.    |...|     |||:..::.         .|||  |:||.||.|:.|..|:.|.
Mouse   561 GYFRPFLDHLTWEAEAAQGQGLEVVERLVTN---------RETP--SWTGPGFVRLREGQEVEFL 614

  Fly   621 VGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPFSLPDRSR 685
            |..:||:|.||.::|::......|....:.:.||..|.....||.:   ...:.||...|...:|
Mouse   615 VTSLPRAMDYDLLLRWEPQVPEQWAELELMVQRPGPVSAHSPCGHV---LPKDDRIQGMLHPNTR 676

  Fly   686 QVVALNEVCLEAGKVYKFRIYF--ERKRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVLADI-R 747
            .:|....||||.|..||.::..  ...|...::..:.:|:|||.|.|.:.|..:|.|...|.: |
Mouse   677 FLVFPRPVCLEPGISYKLKLKLIGTGGRAQPETSYSGLLIDSLVLQPHVLVLEMFSGGDAAALER 741

  Fly   748 KKDYEKYNC-KSSLYDMNYKSDPKCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCK 811
            :..:|:|.| :..|..........|..|...:|..:::||..|.|:|.||||..|..:||.|:||
Mouse   742 RTTFERYRCHEEGLMPSKAPLSETCAPLLISVSALIYNGALPCQCDPQGSLSSECSPHGGQCRCK 806

  Fly   812 PNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQPGYWN 876
            |.||||:||.||.|.|||||.||:||.|:..|:....|:..:|||.|.|..:|..|:.||.|.|.
Mouse   807 PGVVGRRCDVCATGYYGFGPAGCQACQCSPDGALSALCEGTSGQCPCRPGAFGLRCDHCQRGQWG 871

  Fly   877 FPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPL--FGSEIGCRPCRCPETV 939
            ||.||.|.|||.|..||...|.|:.|:|.|.|..|:.|:.|::|:|.  :|.:  ||||.|||..
Mouse   872 FPNCRPCVCNGRADECDTHTGACLGCRDYTGGEHCERCIAGFHGDPRLPYGGQ--CRPCPCPEGP 934

  Fly   940 ASGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPDN-GGTCSKCECSNNVDLYDTG 1003
            .|....|..|..|..:..::|.|:|||:|.|||.||...||:|.. ||.|..||||.|:|..|..
Mouse   935 GSQRHFATSCHRDGYSQQIVCQCREGYTGLRCEACAPGHFGDPSKPGGRCQLCECSGNIDPMDPD 999

  Fly  1004 NCDRQTGACLKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGT------NNTIAHCDRFTG 1062
            .||..||.||:||:.|.|.||..||.||.|.|.:|:|.:|.|:.|||      :..:.|||..||
Mouse  1000 ACDPHTGQCLRCLHNTEGPHCGYCKPGFHGQAARQSCHRCTCNLLGTDPRRCPSTDLCHCDPSTG 1064

  Fly  1063 QCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQC 1127
            ||||||:|||:.||.||.|.|...||.||:.|.|.|..|....||.:||||.|..|||||.|::|
Mouse  1065 QCPCLPHVQGLNCDHCAPNFWNFTSGRGCQPCACHPSRARGPTCNEFTGQCHCHAGFGGRTCSEC 1129

  Fly  1128 QAHYWGNPNEKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGEC 1192
            |..|||:|..:|:.|:||..|....||.|.||:|.|..|:.|.:|::||||:.|.||.|.||..|
Mouse  1130 QELYWGDPGLQCRACDCDPRGIDKPQCHRSTGHCSCRPGVSGVRCDQCARGFSGVFPACHPCHAC 1194

  Fly  1193 FNNWDLILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNLLQNTSVSLVDIEKL 1257
            |.:||.::..|...|......|:|::|.|..||:.|.|..:..||..::.::...:.|.....||
Mouse  1195 FGDWDRVVQDLAARTRRLEQWAQELQQTGVLGAFESSFLNMQGKLGMVQAIMSARNASAASTAKL 1259

  Fly  1258 DYETQSLRDQLQASHGRLSETEQNL----DDIYN-SLSLSGVELESLQNHSRLVQQLSKELKENG 1317
            ...|:.||.::..:..||::.|..|    |:.:| :.:|||:|.:.|..:..| :||.:.|:   
Mouse  1260 VEATEGLRHEIGKTTERLTQLEAELTAVQDENFNANHALSGLERDGLALNLTL-RQLDQHLE--- 1320

  Fly  1318 IQLQESNIEGALNLTRHAY------ERVSNLSTLKDEANELASNTDRNCKRVENL--SNKIQAEA 1374
             .|:.||..||.:..|||:      ||.:|.||.  ......||:....:|.|.|  :.|.....
Mouse  1321 -ILKHSNFLGAYDSIRHAHSQSTEAERRANASTF--AVPSPVSNSADTRRRTEVLMGAQKENFNR 1382

  Fly  1375 DDLANNNKLIE-DYRAELTSLTSQIPELNNQVCGKPGD-PC-DSLCGGAGC------GHCGGFLS 1430
            ..|||...|.. ...|...|||.    :|..|||.||| || .|.||||||      ..||| |.
Mouse  1383 QHLANQQALGRLSAHAHTLSLTG----INELVCGAPGDAPCATSPCGGAGCRDEDGQPRCGG-LG 1442

  Fly  1431 CEHGAKT---------HSEEALKVAKDAETAITSKKDQADQTIRALTQAKLNASEAYEK--AKRG 1484
            |...|.|         |::..|:.|......|.|:   ..:|.|...:|:..|..|.:|  |.||
Mouse  1443 CSGAAATADLALGRARHTQAELQRALVEGGGILSR---VSETRRQAEEAQQRAQAALDKANASRG 1504

  Fly  1485 -FEQSERYLNQTNANIKLAENLFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQ 1548
             .||:.:.|.:...|:|          :|...:.|.|...:.:|.:.||:.:...||:|:.|..:
Mouse  1505 QVEQANQELRELIQNVK----------DFLSQEGADPDSIEMVATRVLDISIPASPEQIQRLASE 1559

  Fly  1549 INRAVSSLKNVEAIIYRTKPDLDRVNNLQSIANATKEKADKILDSANSVVESLAAADESQGKAKD 1613
            |...|.||.:|:.|:..|..|:.|...|...|:..:.:|:.....|.:|..:|..|..:||.|:.
Mouse  1560 IAERVRSLADVDTILAHTMGDVRRAEQLLQDAHRARSRAEGERQKAETVQAALEEAQRAQGAAQG 1624

  Fly  1614 AIQQANSNIELAGQDLEKIDEETYSAEAPANNTAQQVEKLAKKVQKLQNNIMKNDRDAKEITKEA 1678
            ||..|..:.:...|.|:::.|....||...|:..::..:|...::.|:.....|...|....:.|
Mouse  1625 AIWGAVVDTQNTEQTLQRVQERMAGAEKSLNSAGERARQLDALLEALKLKRAGNSLAASTAEETA 1689

  Fly  1679 GSVKLEAMRARGEANNLQSATSATNQTLTDRASRSEN----ARERAKQLLQRASKLTVDTNAKLK 1739
            ||.:   .|||.....|:.......||:...|.|...    |:.||:||...|..|......||:
Mouse  1690 GSAQ---SRAREAEKQLREQVGDQYQTVRALAERKAEGVLAAQARAEQLRDEARDLLQAAQDKLQ 1751

  Fly  1740 DLNDLQTVYLNKNQQLLRLQAEIGPLNKELNEHLIHIKERGSHYRQC 1786
            .|.:|:..|....:.|....|::..|...:...|..|..:...|..|
Mouse  1752 RLQELEGTYEENERALEGKAAQLDGLEARMRSVLQAINLQVQIYNTC 1798

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 54..286 CDD:459653 143/234 (61%)
EGF_Lam 287..343 CDD:238012 33/55 (60%)
Laminin_EGF 355..415 CDD:395007 38/59 (64%)
Laminin_EGF 418..475 CDD:395007 28/56 (50%)
EGF_Lam 477..526 CDD:238012 20/49 (41%)
EGF_Lam 529..567 CDD:214543 20/37 (54%)
EGF_Lam 789..834 CDD:214543 28/44 (64%)
Laminin_EGF 837..885 CDD:395007 20/47 (43%)
Laminin_EGF 883..930 CDD:395007 19/48 (40%)
Laminin_EGF 933..988 CDD:395007 24/55 (44%)
Laminin_EGF 991..1035 CDD:395007 24/43 (56%)
Laminin_EGF 1043..1091 CDD:395007 27/53 (51%)
Laminin_EGF 1094..1142 CDD:395007 24/47 (51%)
Laminin_EGF 1142..1190 CDD:395007 23/47 (49%)
Mplasa_alph_rch 1228..>1771 CDD:275316 162/580 (28%)
cc_DmLAMB1-like_C 1717..1786 CDD:411973 17/68 (25%)
Lamb2NP_032509.2 Laminin_N 50..284 CDD:459653 143/234 (61%)
EGF_Lam 286..338 CDD:238012 33/54 (61%)
Laminin_EGF 350..401 CDD:395007 36/50 (72%)
Laminin_EGF 413..470 CDD:395007 28/56 (50%)
Laminin_EGF 473..527 CDD:395007 23/53 (43%)
EGF_Lam 524..565 CDD:238012 22/40 (55%)
EGF_Lam 784..829 CDD:214543 28/44 (64%)
Laminin_EGF 832..880 CDD:395007 20/47 (43%)
Laminin_EGF 878..925 CDD:395007 19/48 (40%)
EGF_Lam 927..985 CDD:238012 25/57 (44%)
Laminin_EGF 987..>1029 CDD:395007 23/41 (56%)
Laminin_EGF 1039..1093 CDD:395007 27/53 (51%)
Laminin_EGF 1096..1144 CDD:395007 24/47 (51%)
Laminin_EGF 1144..1191 CDD:395007 22/46 (48%)
Domain II 1191..1410 66/229 (29%)
SMC_prok_B <1204..1571 CDD:274008 116/391 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1339..1365 7/27 (26%)
Domain alpha 1411..1443 18/32 (56%)
Domain I 1444..1799 93/371 (25%)
Smc <1446..>1787 CDD:440809 90/356 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1679..1701 7/24 (29%)
cc_LAMB2_C 1728..1799 CDD:411970 19/71 (27%)

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