DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and lamc1

DIOPT Version :10

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_001090659.1 Gene:lamc1 / 100036631 XenbaseID:XB-GENE-478553 Length:1592 Species:Xenopus tropicalis


Alignment Length:1911 Identity:489/1911 - (25%)
Similarity:781/1911 - (40%) Gaps:482/1911 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LRLIVVIVLALLSWQWDPVDSQRPPQHGRRDRPKYPPNKFIKTHPCERSSCYPATGNLLIGRENR 68
            |.::.|::|..:....|....:..||   |..|::.            ::.:.||          
 Frog     6 LAVLAVLLLGTVRAAMDECYEEGSPQ---RCMPEFV------------NAAFNAT---------- 45

  Fly    69 LTASSTCGLHSPERFCILSHLQ--DKKCFLCDTRE-ETKH-----DPYKNHRIGQIIYKTKPGTN 125
            :.|::|||. .||.:|:.:.:.  .|.|.:||:.: ..:|     ..|.|.  .:|         
 Frog    46 VVATNTCGT-PPEEYCVQTGVTGVTKSCHICDSGQFHLQHGAEYLTDYNNQ--AEI--------- 98

  Fly   126 IPTWWQSENG----KENATIQLDLE--AEFHFTHLIITFTTFRPA--AMYIERSFDFGQTWHIYR 182
              |||||:..    :..:||.|.|.  ..|..|::.:.|.|.||.  |:| :|:.:.| .|..|:
 Frog    99 --TWWQSQTMLAGIQYPSTINLTLHLGKAFDITYVRLKFHTSRPESFALY-KRTHEDG-PWIPYQ 159

  Fly   183 YFAYDCKESFP----GVPTVLENITDVMCTSRYSNVEPSRNGEVIFRVL---PPNINVTDPYAEH 240
            |::..|::::.    |.....|:....:||..:|::.|...|.|.|..|   |...|..:  :..
 Frog   160 YYSGSCEKTYQKFNRGFIRTGEDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDN--SPV 222

  Fly   241 VQNQLKMTNLRIQMTKLHKLGDNLL-DSRLENEEKYYYGISNMVVRGSCSCYGHASQCLPLDPAF 304
            :|..:..|::|:.:.:|:..||.:. |.::  .:.|||.||:..|.|.|.|.||||:|:      
 Frog   223 LQEWVTATDIRVTLNRLNTFGDEVFSDPKV--LKSYYYAISDFAVGGRCKCNGHASECV------ 279

  Fly   305 SQADNE-DGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHFDE 368
               .|| :.:|   |.|.|||.|.:||:|..|:||.||:.:.....|.|..|.||..:..|:||.
 Frog   280 ---RNEFEKIV---CNCKHNTFGSDCEKCLPFYNDRPWRRSTADSPNECLPCNCNGRSQECYFDP 338

  Fly   369 AVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSDDGICDS 433
            .::.::|  .||.|..|..||.|.:||.|...:||   ||  :...|..|.|:|.||.... ||:
 Frog   339 ELYRSTG--HGGHCTGCADNTDGPNCERCRENYYR---QD--NNEPCHACQCNPVGSLSTQ-CDN 395

  Fly   434 LNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTLNNSGCVMRTGEC 498
            .         |.|.||..|.|.:|::|:.|:.:|   ...||.||.|||.|:.:.  |.:.||.|
 Frog   396 Y---------GRCSCKPGVMGEKCDRCQPGFHSL---TEAGCRPCACNPAGSTDE--CNVETGRC 446

  Fly   499 KCKKYVTGKDCNQCMPETYGLSE-SPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQP 562
            .||..|.|.:|.:|.|..:.|.| :|.||:.|.|....|.                     ||..
 Frog   447 SCKDNVEGFNCERCKPGFFHLDEANPRGCTPCFCYGHSSV---------------------CSSA 490

  Fly   563 KQNYFIPLLPEVHEAEVVDECISYGANGNCSLVAETPDGSFTGIGFTRVPENSELVFTVGDIPRS 627
                         |...|...:|...:|.....|:..|||...:.:  |.::|            
 Frog   491 -------------EGYRVSSIVSTFESGVEGWTAQQRDGSEYSLSW--VSDSS------------ 528

  Fly   628 MPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIP--FSLPDR--SRQVV 688
                                                   |.:..||:..|  |..|.:  ..|..
 Frog   529 ---------------------------------------AVSVISESYFPIYFIAPAKFLGNQGA 554

  Fly   689 ALNEVCLEAGKVYKFRIYFERKRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVLADIRKKDYEK 753
            :..:     ...:.||:    :|.|.......::::...|  |:.|..|.||:        .|..
 Frog   555 SYGQ-----NLTFSFRV----ERRDTRLSAEDLVLEGAGL--RVSVPLIAQGN--------SYPS 600

  Fly   754 YNCKSSLYDMNYKSD----PKC------QNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGG-- 806
            ...:..::.|:..:|    |..      :.|.|:.::.:....|..:......:|.|....|.  
 Frog   601 ETTQRYIFRMHEATDYPWRPSVSPFEFQKMLQNLTAIKIRGSYSERSAGFLEEVSLVTAVAGAGP 665

  Fly   807 ------YCQCKPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGR 865
                  .|.|....:|:.|::||||                                     |.|
 Frog   666 SAPWVEICSCPTGYIGQFCERCAPG-------------------------------------YRR 693

  Fly   866 ECNQCQPGYWNFPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGC 930
            |    .|....:..|.:|.||||:.||||..|.| |||.:|.|..|:.|.:||||:...||...|
 Frog   694 E----NPSQGPYSPCVLCTCNGHSDTCDPESGVC-DCQHNTAGPHCERCSEGYYGDSTTGSASDC 753

  Fly   931 RPCRCPETVASGLAHADGCSLDTRNNNMLC-HCQEGYSGSRCEICADNFFGNP--DNGG--TCSK 990
            :||.||        ....|::..|...::| :|..|.:|.|||:|.|.:||:|  :||.  .|..
 Frog   754 QPCPCP--------GGSSCAVVPRTKEVVCTNCPLGTTGKRCELCDDGYFGDPLGENGAPRPCRI 810

  Fly   991 CECSNNVDLYDTGNCDRQTGACLKCLYQTTGDHCELCKDGFFGDALQQN----CQQCECDFLGTN 1051
            ||||||:|....|||||.||.||||:|.|.|.:|:.|:|||:|:.|.||    |:.|.|:..||.
 Frog   811 CECSNNIDPNAVGNCDRLTGECLKCIYNTGGFYCDRCRDGFYGNPLAQNPDLKCRACSCNPYGTV 875

  Fly  1052 NTIAHCDRFTGQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCK 1116
            ...:.|::.||||.|||:|....|..|....:.:.||.|||.|:|..:|:...||:..||||:|.
 Frog   876 KGQSGCNQVTGQCECLPHVTERDCSACEPGFYNLLSGRGCERCDCHSLGSTSGQCDVRTGQCECH 940

  Fly  1117 PGFGGRACNQCQAHYWGNPNEKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYI- 1180
            ||..|:.|.||:.:::|...|.|:||:||..|:...|| :|.|.|.|..|..|.:|::|...|. 
 Frog   941 PGISGQQCQQCEPNHFGFGPEGCKPCDCDPEGSGSLQC-KEDGRCECKSGFVGTRCDQCEENYFY 1004

  Fly  1181 -GQFPHCSPCGECFNNWDLILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNLL 1244
             ...|.|..|..|:.                :::.|..:|.|              |||.:.:||
 Frog  1005 NRSGPGCQECPACYR----------------LVKDKVNEQRG--------------KLQELEDLL 1039

  Fly  1245 QNTSVSLVDIEKLDYETQSLRDQLQASHGRLSETEQNLDDIYNSLSLSGVELESLQNHSRLVQQL 1309
            :|.|..          .:::.|  ||...||.|.|:.::|:.                  |..|.
 Frog  1040 KNLSTG----------EENITD--QAFEERLREAEKAVNDLL------------------LDAQS 1074

  Fly  1310 SKELKENGI-QLQESNIEGALNLTRHAYERVSNLSTLKDEANELASNTDRNCKRVENLSNKIQAE 1373
            ||::.:..: :|.|.|...:..|     ||:.|:       .::..:||:          :.|..
 Frog  1075 SKDVDQGMLDRLAEINTTLSFQL-----ERLQNI-------RDMIRDTDK----------QAQEA 1117

  Fly  1374 ADDLANNNKLIEDYRAELTSLTSQIPELNNQVCGKPGDPCDSLCGGAGCGHCGGFLSCEHGAKTH 1438
            .|.:.|...:|:..|.:|......|..::.......|||.:..            |..|...|. 
 Frog  1118 RDRVENTEFIIDSARVQLEKAKMAIANVSITPPESTGDPNNMT------------LLAEEARKL- 1169

  Fly  1439 SEEALKVAKDAETAITSKKDQADQTIRAL-------TQAKLNASE---AYEKAKRGFEQSERYLN 1493
            :|..::.|:|.|.|.....|.|::.:|.|       .|..|:..|   .|.:||....:.|:..:
 Frog  1170 AERHMQEARDIEKAAKEANDTANEALRLLQKTLASENQTALDIEELNRKYAQAKDIARELEKQAS 1234

  Fly  1494 QTNANIKLAENLFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQINRAVSSLK- 1557
            :.:|..:.|.|..:.:   ..|.|:.||......|...| .::.|.||:::|.|:..|....|: 
 Frog  1235 KVHAEAEEAGNRALQI---YANLTSVPSIDTTALQNEAD-KIQKEAEELDSLIDRKLRDYEDLRE 1295

  Fly  1558 -------NVEAIIYRTKPDLDRVNNLQSIANATKEKAD-------KILDSANSVVESLAAADESQ 1608
                   .|:.::.:.|.:....:.|.:.|:|.|.:|:       :.|..||.::..|...|:..
 Frog  1296 DMRGREMEVKNLLDKGKTEQQTADQLLARADAAKAQAEEAAKKGRETLQEANDILNKLRDFDKRV 1360

  Fly  1609 GKAKDAIQQANSNIELAGQDLEKIDEETYSAEAP---ANNTAQQVEKLAKKVQKLQNNIMKN--- 1667
            ...|.|.:.|...|.:..|.:.:.:.:|..||:.   ||..|:..:..|::.:.|.|.:.|.   
 Frog  1361 NDNKTAAEAALRKIPMIAQTIAEANNKTRQAESALGNANADARGAKSKAEEAEALANTVQKKAAT 1425

  Fly  1668 -----DRDAKEITKEAGSV------------KLEAMRARGEANNLQSATSATNQTLTDRASRSEN 1715
                 |...||:|...|.:            :|:..:|..|::. :.|..|:|.| .|..|.:.|
 Frog  1426 ARAEADNTFKEVTDLDGELQDMLQQLQEAENQLKKKQAEAESDE-KMAEMASNAT-KDAESNANN 1488

  Fly  1716 ARERAK-------QLLQRASKL-TVDTN-------------------------AKLKDLNDLQTV 1747
            :::...       :||.|..:| :||..                         |:|::.::||.|
 Frog  1489 SKKSVNGVLATIDELLSRLGQLDSVDVGQLTVLEKTLDDAKNQLRDSDLDRKLAELQESSNLQRV 1553

  Fly  1748 ----YLNKNQQLLRLQAEIGPLNKEL 1769
                |.....|:||..|.:..:...|
 Frog  1554 ALDSYSRDIDQILRDIANLEDIKNTL 1579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 54..286 CDD:459653 65/255 (25%)
EGF_Lam 287..343 CDD:238012 24/56 (43%)
Laminin_EGF 355..415 CDD:395007 21/59 (36%)
Laminin_EGF 418..475 CDD:395007 17/56 (30%)
EGF_Lam 477..526 CDD:238012 20/49 (41%)
EGF_Lam 529..567 CDD:214543 5/37 (14%)
EGF_Lam 789..834 CDD:214543 11/52 (21%)
Laminin_EGF 837..885 CDD:395007 6/47 (13%)
Laminin_EGF 883..930 CDD:395007 24/46 (52%)
Laminin_EGF 933..988 CDD:395007 19/59 (32%)
Laminin_EGF 991..1035 CDD:395007 27/43 (63%)
Laminin_EGF 1043..1091 CDD:395007 17/47 (36%)
Laminin_EGF 1094..1142 CDD:395007 19/47 (40%)
Laminin_EGF 1142..1190 CDD:395007 17/49 (35%)
Mplasa_alph_rch 1228..>1771 CDD:275316 132/628 (21%)
cc_DmLAMB1-like_C 1717..1786 CDD:411973 17/90 (19%)
lamc1NP_001090659.1 LamNT 27..267 CDD:214532 69/284 (24%)
EGF_Lam 268..313 CDD:238012 24/56 (43%)
Laminin_EGF 325..378 CDD:395007 21/59 (36%)
Laminin_EGF 381..428 CDD:395007 19/59 (32%)
Laminin_EGF 428..475 CDD:395007 19/48 (40%)
Laminin_B 541..671 CDD:459652 23/148 (16%)
Laminin_EGF 707..753 CDD:395007 24/46 (52%)
EGF_Lam 755..803 CDD:238012 18/55 (33%)
Laminin_EGF 811..855 CDD:395007 27/43 (63%)
EGF_Lam 866..916 CDD:238012 18/49 (37%)
EGF_Lam 918..963 CDD:214543 18/44 (41%)
EGF_Lam 965..1012 CDD:238012 17/47 (36%)
Domain II and I. /evidence=ECO:0000250 1013..1592 137/668 (21%)
Smc <1018..>1544 CDD:440809 125/626 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1456..1489 9/34 (26%)

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