DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herp and herpud1

DIOPT Version :9

Sequence 1:	NP_609151.2	Gene:	Herp / 34065	FlyBaseID:	FBgn0031950	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	XP_005159177.1	Gene:	herpud1 / 565499	ZFINID:	ZDB-GENE-050913-47	Length:	408	Species:	Danio rerio

Alignment Length:	499	Identity:	137/499 - (27%)
Similarity:	204/499 - (40%)	Gaps:	169/499 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SVRLLIKSSNQQYEDL---NVDSDLCWTVQRLKKHLSLIYPGKPLIQDQKLIYSGKLLDDSQKIS 89
            ::.|:||:.||.:.|.   .|.:|  |||:.||.|||.:||..|..:||:||||||||.|:..|
Zfish    11 TISLVIKTPNQFHGDQLIEGVRAD--WTVKDLKCHLSKVYPNNPAEKDQRLIYSGKLLLDNLLI- 72

  Fly    90 EVIRSYKDVYQQ-----HHIFHLVCASKQVIRPAAKAPTVPQKDAVPAGPEVTGNANELRQRHAP 149
                  :||:.:     ....|||||.:.  :||::         :.|.|:||          :.
Zfish    73 ------RDVFSKVPSDTKPTLHLVCAVRP--QPASQ---------LGARPKVT----------ST 110

  Fly   150 HQQQAQQG------NAGPHVT---GDIGLANPWTHFWQQSQGAAP--AANASA-----------S 192
            |||.:|..      ::||.||   ...||.       |:.....|  :||.||           .
Zfish   111 HQQSSQPSPLTPSQSSGPSVTSLHSTDGLR-------QRGHATLPDTSANTSAPVTAAMNHPAFP 168

  Fly   193 PHALFQQQALIYNAWMQQAYAQ--YMQ-QLTLRSTLPGSNQSGLPPPTQPLLPSVPLIAGRNFGE 254
            .::|:..|.|:   |:||.||:  ||| |..:.:.      :..|..|.....|:|:      |.
Zfish   169 TYSLYSPQQLL---WLQQMYARQYYMQYQAAMAAA------ASAPMTTPAAASSLPV------GP 218

  Fly   255 VQQVAGAAAAPAAQVPADPQINGAPQNRNFPN----------------------IQEEPEMH-DW 296
            .|     ||.||| :|....||..|.|:|.|.                      :::|.:|: ||
Zfish   219 HQ-----AAVPAA-LPNQGPINDLPANQNAPGPAFINPEGANQNLRMNAQGGPVVEDEEDMNRDW 277

  Fly   297 LDSFFSFTRLAIFVTVLYFNSSALRCLLVVLIAGAIYLYHIG--VLRRRRERNNNN-----INRN 354
            ||..::.:||.:|::::||.||..|.:||:.....:||:..|  ..|:|.:....|     :|:|
Zfish   278 LDWMYTASRLGVFLSIVYFYSSMSRFILVMSSLVIMYLHTAGWFPFRQRPQARPQNEPAPEVNQN 342

  Fly   355 NNAGDAAAFAAVQQIQRMMDAAVQRENNDPQAANEPGAVPAAGPAAAGEQDAIDAPPAGAPVAPA 419
            ...                    |.|:..|:        |.|.||...:...:|         ||
Zfish   343 QQN--------------------QNEDQHPE--------PVAPPAEVEDVGVVD---------PA 370

  Fly   420 SAANPEPTDVSAEAVEPPNANNSVISVVRTFVITFFTSLLPEAP 463
            ..|.|.|      .|..|     ::.....|...||.||:||.|
Zfish   371 MTAVPVP------QVRAP-----ILWTAWVFFKAFFASLIPEPP 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herp	NP_609151.2	Herp_N	28..110	CDD:176385	36/89 (40%)
Herp	NP_609151.2	UBQ	29..110	CDD:214563	36/88 (41%)
herpud1	XP_005159177.1	UBQ	12..92	CDD:294102	36/88 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592811
Domainoid	1	1.000	64	1.000	Domainoid score	I10148
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	140	1.000	Inparanoid score	I4482
OMA	1	1.010	-	-		QHG45891
OrthoDB	1	1.010	-	-		D1251727at2759
OrthoFinder	1	1.000	-	-		FOG0003073
OrthoInspector	1	1.000	-	-		otm26382
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12943
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2439
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.010