DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herp and Herpud2

DIOPT Version :9

Sequence 1:	NP_609151.2	Gene:	Herp / 34065	FlyBaseID:	FBgn0031950	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	XP_006242785.1	Gene:	Herpud2 / 300463	RGDID:	1307343	Length:	402	Species:	Rattus norvegicus

Alignment Length:	486	Identity:	136/486 - (27%)
Similarity:	204/486 - (41%)	Gaps:	135/486 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QKNPETSVRLLIKSSNQQYEDLNVDSDLCWTVQRLKKHLSLIYPGKPLIQDQKLIYSGKLLDDSQ 86
            |...|..|.|:||:.||:|.|..:...|.|||.:||.|||.:||.|||.:||:|:|||:||.|..
  Rat     3 QSGMEIPVTLIIKAPNQKYSDQTISCFLNWTVGKLKTHLSNVYPSKPLTKDQRLVYSGRLLPDHL 67

  Fly    87 KISEVIRSYKDVYQQHHIFHLVCASKQVIRPAAKAPTVPQ---------------------KDAV 130
            ::.:::|.    ..::|:.||||||:       ..|:.|:                     .|:.
  Rat    68 QLKDILRK----QDEYHMVHLVCASR-------SPPSSPKSSTDGESHGALASSTNSNSDHSDST 121

  Fly   131 PAGPE------VTGNANELRQRHAPHQQQAQQGNAGPH-----VTGDIGLANPWTHFWQQSQGAA 184
            ...|.      |.|::..||.|..|   |||...|..|     :.|::....|       .||..
  Rat   122 TPSPSQESLSLVAGSSEGLRHRTLP---QAQTDPAQSHQFPYVIQGNVDHQFP-------GQGVP 176

  Fly   185 PAANASASPHALFQQQALIYNAWMQQAYAQ--YMQ-QLTLRSTLPGSNQSGLPPPTQPLLPSVPL 246
            |.       ..::...:.:...|.||.|||  ||| |..:.:....|..|.....:.||
  Rat   177 PG-------FPMYPAFSPLQMLWWQQMYAQQYYMQYQAAVTAQATSSASSAQHAASSPL------ 228

  Fly   247 IAGRNFGEVQQVAGAAAAPAAQVPADPQINGAPQN-----RNFPNIQEEPEMHDWLDSFFSFTRL 306
                   .:..|.|....||..:.|  |.|| |:|     :..|.:.||....||||..::|:|.
  Rat   229 -------NLAHVPGEEPPPAPNLVA--QENG-PENVQMNAQGGPVLNEEDFNRDWLDWVYTFSRA 283

  Fly   307 AIFVTVLYFNSSALRCLLVVLIAGAIYLYHIGVLRRRRERNN----NNINRNNNAGDAAAFAAVQ 367
            |:.::::||.||..|.::|:.....:||:..|....|:|...    ||::.||. |..|....::
  Rat   284 AVLLSIVYFYSSFSRFIMVMGAMLLVYLHQAGWFPFRQEGGQQQAPNNVDANNE-GQNANNLELE 347

  Fly   368 QIQRMMDAAVQRENNDPQAANEPGAVPAAGPAAAGEQDAIDAPPAGAPVAPASAANPEPTDVSAE 432
            :::|:||..::.|:.:.                |||    ||..|..|...|||
  Rat   348 EMERLMDDGLEDESGED----------------AGE----DASAAQRPGLMASA----------- 381

  Fly   433 AVEPPNANNSVISVVRTFVITFFTSLLPEAP 463
                           .:|:.||||||:||.|
  Rat   382 ---------------WSFITTFFTSLIPEGP 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herp	NP_609151.2	Herp_N	28..110	CDD:176385	36/81 (44%)
Herp	NP_609151.2	UBQ	29..110	CDD:214563	36/80 (45%)
Herpud2	XP_006242785.1	Herp_N	9..87	CDD:176385	36/81 (44%)
Herpud2	XP_006242785.1	UBQ	10..87	CDD:214563	36/80 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351068
Domainoid	1	1.000	66	1.000	Domainoid score	I9698
eggNOG	1	0.900	-	-		E1_KOG4583
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10756
Inparanoid	1	1.050	134	1.000	Inparanoid score	I4486
OMA	1	1.010	-	-		QHG45891
OrthoDB	1	1.010	-	-		D1251727at2759
OrthoFinder	1	1.000	-	-		FOG0003073
OrthoInspector	1	1.000	-	-		otm46173
orthoMCL	1	0.900	-	-		OOG6_108340
Panther	1	1.100	-	-	O	PTHR12943
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2439
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770