DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment santa-maria and Scarb2

DIOPT Version :9

Sequence 1:	NP_609121.2	Gene:	santa-maria / 34024	FlyBaseID:	FBgn0025697	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_446453.1	Gene:	Scarb2 / 117106	RGDID:	621882	Length:	478	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	130/460 - (28%)
Similarity:	232/460 - (50%)	Gaps:	49/460 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DWIMHKEMALAPDTRVYENWKSPPIDLSLDIYLYNWTNPEDF--GNLSTKPILEQVGPYRFIERP 104
            |..:.|.|.|...|:|:::|:.||:.:.:..|.:|.||||:.  |.:   |:||:||||.:.|..
  Rat    34 DQTIEKNMVLQNGTKVFDSWEKPPLPVYIQFYFFNVTNPEEILQGEI---PLLEEVGPYTYRELR 95

  Fly   105 DKVDIHWHPENASVTYRRRSLFYFDAAGSNGS-LDDEITTLNAVALSAAATAKYWPPVKRSLVDV 168
            :|.::.:.....:::......:.|:...|.|. ..|.|.|:|...|:....|:  .|..|.:::.
  Rat    96 NKANVQFGENGTTISAVTNKAYIFERNQSVGDPTVDLIRTINIPLLTVVEMAQ--QPFLREIIEA 158

  Fly   169 GLKMYGAEMSVQKSIDELLFTGYNDAMIDVAMAMPIFGDEVKVPFDKFGWFYTRNGSADLTGVFN 233
            .||.|...:.|..::.|||: ||.|   :|...:.||..:|.   ..||.||.|||:.|  |.:.
  Rat   159 MLKAYQQTLFVTHTVHELLW-GYKD---EVLSLVHIFRPDVS---PNFGLFYERNGTND--GEYV 214

  Fly   234 VFTGADQLAKLGQMHSWNYQENTGFFDS-YCGMTNGSAGE-FQPQHLKPGDSVGLFTPDMCRTIP 296
            ..||.|......::..||.:.:..::.: .|.|.||:.|: |.|. :...:::.:|..|.||::.
  Rat   215 FLTGEDNYLNFTKIVEWNGKTSLDWWTTDTCNMINGTDGDSFHPL-ISKDETLYIFPSDFCRSVY 278

  Fly   297 LDYVETVDIEGLEGYKFSGGPRSVDNGTQYPENLCFC--GGQCVPSGVMNISSCRFGSPVFMSYP 359
            :.:....::|||..:::......:.|.:   ||..||  .|.|:.:||:|:|.|:.|:|:.||:|
  Rat   279 ITFSSFENVEGLPAFRYKVPAEILANSS---ENAGFCIPEGNCMDAGVLNVSICKNGAPIIMSFP 340

  Fly   360 HFFNADPYYPDQVEGLSPNQKDHEFYMVVQPSTGIPLEVAARFQVNMLVEPIQGISLYTGIPRIF 424
            ||:.||..:...::|:.||:::||.::.:.|.|||.|..|.|||:|..|:.:........|..:.
  Rat   341 HFYQADEKFVSAIKGMRPNKEEHESFVDINPLTGIILRGAKRFQINTYVKKLDDFVETGNIRTMV 405

  Fly   425 FPLVWFEQKVRITPDMADQLKV----------LPIVMLSGHIFAGICLIVGITLLCWTPVQILLA 479
            ||:::..:.|.|..:.|.|||.          :|.::::..:|.|:       :..|       .
  Rat   406 FPVMYLNESVLIDKETASQLKSVINTTLIVTNIPYIIMALGVFFGL-------IFTW-------L 456

  Fly   480 SCRNR 484
            :||.:
  Rat   457 ACRGQ 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
santa-maria	NP_609121.2	CD36	23..474	CDD:279474	128/448 (29%)
Scarb2	NP_446453.1	CD36	34..457	CDD:395898	128/454 (28%)
Scarb2	NP_446453.1	Important for interaction with GBA. /evidence=ECO:0000250	155..191		11/39 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45589
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930