Protein Alignment Wnt6 and WNT6

DIOPT Version :10

• Sequence 1: NP_609108.3
• Gene: Wnt6 / 34010
• FlyBaseID: FBgn0031902
• Length: 420
• Species: Drosophila melanogaster
• Sequence 2: NP_006513.1
• Gene: WNT6 / 7475
• HGNCID: 12785
• Length: 365
• Species: Homo sapiens
• Alignment Length: 421
• Identity: 169/421 - (40%)
• Similarity: 234/421 - (55%)
• Gaps: 65/421 - (15%)

  Fly     2 RLLMVIAILIFAMPMTGFGWAEGTNILLDPNLMCKKTRRLRGKLAEICRHDSALLKEIIINGINL 66
            ||.:::.:|:....:.|..||.|:.:::||..:|:|.|||.|:.||:|:.:..::.| :..|..|
Human     8 RLGLLLLLLLCPAHVGGLWWAVGSPLVMDPTSICRKARRLAGRQAELCQAEPEVVAE-LARGARL 71

  Fly    67 GFRECEFQFRNRRWNCTVLRKSMRKILMRDSRETGFVNAITAAGVTYAVTKACTMGQLVECSCDK 131
            |.|||:||||.|||||:...|:..:||.:|.|||.||.||||||.::|||:||:||:|::|.|.
Human    72 GVRECQFQFRFRRWNCSSHSKAFGRILQQDIRETAFVFAITAAGASHAVTQACSMGELLQCGCQ- 135

  Fly   132 AHMRRNGGQPQMVTAATAEAALERQQQAAMLRQQMPLQDQHPSQRLSRMNNASTMTDIAPVEHRG 196
                                                                      ||   ||
Human   136 ----------------------------------------------------------AP---RG 139

  Fly   197 GRNRRPGGRRGRRKFWDNIKFPEGQ--WEWGGCSDNVNFGLRHSRVFLDAKQRQRRSDLGTLVKF 259
            ....||.|..|..........|||.  ||||||.|:|:||...||:|:||:.::.|.|:..||:.
Human   140 RAPPRPSGLPGTPGPPGPAGSPEGSAAWEWGGCGDDVDFGDEKSRLFMDARHKRGRGDIRALVQL 204

  Fly   260 HNNNAGRLAIRDAMRLECKCHGLSGSCTVKTCWLKMPPFREVAGRLRDRYDSARKVTLRNDGNSF 324
            |||.|||||:|...|.|||||||||||.::|||.|:||||||..||.:|:..|.:|...|||.:.
Human   205 HNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKAL 269

  Fly   325 MPESPHARPANKYQLVFADDSPDFCTPNSKTGALGTQGRECNVTSSGSDRCDRLCCNRGHTRRIV 389
            :|.....:|..:..|::|.||||||.||.:||:.||:||.||.::.....||.|||.|||.:..|
Human   270 LPAVRTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESV 334

  Fly   390 EEQTNCKCVFKWCCEVTCEKCLEHRAVNTCL 420
            :.:.||.|.|.|||.|.|.:|...:.::.||
Human   335 QLEENCLCRFHWCCVVQCHRCRVRKELSLCL 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wnt6	NP_609108.3	Wnt_Wnt6	29..420	CDD:381712	160/392 (41%)
WNT6	NP_006513.1	Wnt_Wnt6	35..365	CDD:381712	160/392 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	140..164		6/23 (26%)