Protein Alignment mEFG1 and EFTUD2

DIOPT Version :10

• Sequence 1: NP_609105.1
• Gene: mEFG1 / 34004
• FlyBaseID: FBgn0263133
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_004238.3
• Gene: EFTUD2 / 9343
• HGNCID: 30858
• Length: 972
• Species: Homo sapiens
• Alignment Length: 843
• Identity: 181/843 - (21%)
• Similarity: 309/843 - (36%)
• Gaps: 224/843 - (26%)

  Fly    40 ERIRNIGISAHIDSGKTTLTERILFYTGRIAEMH-EVRGK-DNVGATMDSMELERQRGITIQSAA 102
            |.|||:.:..|:..|||...:.:      |.:.| |:|.: |......|.:..|::||:.|:|..
Human   127 ELIRNVTLCGHLHHGKTCFVDCL------IEQTHPEIRKRYDQDLCYTDILFTEQERGVGIKSTP 185

  Fly   103 TYTLWKDTN-----INIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLTVNRQMKRYN 162
            ...:..||.     .||:||||||:|:.||...||:.||.||.:.|..||...|..:.:...:..
Human   186 VTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTERLIKHAVQER 250

  Fly   163 VPCLAFINKLDRLGSNPYRVLSQMRSKMNHNAAFIQLPIGVESNCKGIVDLVREKAIYFEGEHGM 227
            :.....|||:|||         .:..|:....|:.:|        :.|||.|......:..:..:
Human   251 LAVTVCINKIDRL---------ILELKLPPTDAYYKL--------RHIVDEVNGLISMYSTDENL 298

  Fly   228 ----------------------------------DIRLDEIPQ----DMRVESLERRQELIEHLS 254
                                              ||...|..:    |:......|:.......|
Human   299 ILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKAPTS 363

  Fly   255 NADETLGELFLE---------------EKPFTEDDIKAALRRTCINRTFTPVLVGTALKNKG-VQ 303
            ::..:..|..||               ..|.|.|::...|.:..:.....|:|.....|..| ..
Human   364 SSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFT 428

  Fly   304 PLLDAVLDYLPNPGEVENLGFIEKEGQDPEKVVLNPARDGKDPFVGLAFK--------------- 353
            ..:|..:.::|:|          |.|..|:  :.:....|.|..:|.|..
Human   429 GFVDMCVQHIPSP----------KVGAKPK--IEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTKM 481

  Fly   354 ------LEAGRFGQLTYLRCYQG----VLRKGDNIFNARTNKKVRIARL----VRLHSNQMEDVN 404
                  ::...||::.....:.|    ||.:...:.:...::...:.||    .|.|.    :||
Human   482 YSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHI----EVN 542

  Fly   405 EVYAGDIFALFGVDCASGDTFT-TNPKNNLSMESIFVP-----EPVVSMAIKPNNTKDRDNFSKA 463
            .|.||:...:.|||.....|.| |.|:.|...: ||.|     ..|:.:|::|.|..:.......
Human   543 RVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQ-IFRPLKFNTTSVIKIAVEPVNPSELPKMLDG 606

  Fly   464 IARFTKEDPTFHFFFDNDVKET---LVSGMGELHLEIYAQRMEREYG-CPVTLGKPKVAFRETLV 524
            :.:..|..|:    ....|:|:   ::.|.|||:|:.....:.:.|. ..:.:..|.|.|.||:|
Human   607 LRKVNKSYPS----LTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVTFCETVV 667

  Fly   525 G----PCEFDYLHKKQSGGSGQYARIIGVMEPLPP---------------NQNTLLEF------- 563
            .    .|..:..:||.        :|..:.|||..               |:..|.||
Human   668 ETSSLKCFAETPNKKN--------KITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYDW 724

  Fly   564 ---------------------VDETVGTNVPKQFVPGVE----KGYREMAEKGMLSGHKLSGIRF 603
                                 ||:|:.:.|.|..:..|:    :|::....:|.|....:..::|
Human   725 DLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLCDELIRNVKF 789

  Fly   604 RLQD----------GGHHIVDSSELAFMLAAHGAIKEVFQNGSWQILEPIMLVEVTAPEEFQGAV 658
            ::.|          ||..|:.:        |...:...|...:.:::||...|||.||.:...||
Human   790 KILDAVVAQEPLHRGGGQIIPT--------ARRVVYSAFLMATPRLMEPYYFVEVQAPADCVSAV 846

  Fly   659 MGHLSKRHGIITGTEGTEG--WFTVYAEVPLNDMFGYAGELRSSTQGKGEFTMEYSRYSPCLP 719
            ...|::|.|.:|......|  .:|:.|.:|..|.||:..:||:.|||:. |::....:...:|
Human   847 YTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQA-FSLSVFHHWQIVP 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mEFG1	NP_609105.1	FusA	38..731	CDD:440248	181/843 (21%)
EFTUD2	NP_004238.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54
		EFTUD2	4..110	CDD:464968
		PRK13351	122..954	CDD:481252	181/843 (21%)