Protein Alignment MICU1 and Micu3

DIOPT Version :10

• Sequence 1: NP_001097110.1
• Gene: MICU1 / 33999
• FlyBaseID: FBgn0031893
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_084386.1
• Gene: Micu3 / 78506
• MGIID: 1925756
• Length: 523
• Species: Mus musculus
• Alignment Length: 500
• Identity: 128/500 - (25%)
• Similarity: 203/500 - (40%)
• Gaps: 127/500 - (25%)

  Fly    96 WGKVKRMLTPKVDADAGQRPSSAADVNGEDKSSESE--SEDSEDEEAGSDL----------HLHE 148
            ||:    |:....|..|........:.|:.::..||  :.:.||...|..|          .:..
Mouse    63 WGE----LSIAAAAGGGLVGLVCYQLYGDPRADPSELAAPELEDPPRGRGLLPIPVAAAKETVAT 123

  Fly   149 GKKIREKVGF----RERKIIEYENRIRQFSTPDKVFRYFATIQVPVADDRHEVYMTPTDFLTSMT 209
            |:.|.|.:..    |||:                 ||.||:|:.     ..:::|||.||:.::|
Mouse   124 GRAITEDLDLYATSRERR-----------------FRLFASIEC-----EGQLFMTPYDFILAVT 166

  Fly   210 PGMKQPDGLGLDQYRRYDP------KSVGEQ-LNLHLEK--------NSIFYKLGSYGLITFSDY 259
            ..               :|      ||:.:| |:..|.:        :.:|..|...|:|::::|
Mouse   167 TD---------------EPKFAKTWKSLSKQELSQMLSETPPVWKGSSKLFRNLKERGVISYTEY 216

  Fly   260 IFLLTVLSISRRHFEIAFRMFDLNGDGDVDCEEFEMVATLVRQQTSMGTRHRD------------ 312
            :|||.:|:.....|.|||.|||.:|:..||.:||.::..:.|::........|
Mouse   217 LFLLCILTKPHAGFRIAFNMFDTDGNEMVDKKEFLVLQEIFRKKNEKRETKGDEEKRAMLRLQLY 281

  Fly   313 --HANTGNTFKG-------------------------------------VNSALITYFFGPNMDE 338
              |:.|.:..|.                                     .::.|:.:|||.....
Mouse   282 GYHSPTNSVLKTDAGELVSRSYWDTLRRSTSQALFSDLAERADDITSLVADTTLLVHFFGKKGKA 346

  Fly   339 KLTIEKFLDFQEQLQREILSLEFERKEPNDEGNITEADFAELLLAYAGYPLKKKQKKLKRVKRRF 403
            :|..|.|..|.:.||.|:|.:|| ....|....|:|.|||.:||.|..  ::.....|:.|:...
Mouse   347 ELNFEDFYRFMDNLQTEVLEIEF-LSYSNGMNTISEEDFAHILLRYTN--VENTSVFLENVRYSI 408

  Fly   404 RDHGKGISKQDYLDFFHFLNNINDVDTALTFYHIAGASIDQQTLQHVAKTVAMVNLSDHVVDVVF 468
            .:. |||:..::..||.||||:.|...||..|:.|..||.|...:........:.||.|:|:.||
Mouse   409 SEE-KGITFDEFRSFFQFLNNLEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKLSPHLVNTVF 472

  Fly   469 TIFDENNDNQLSNKEFISVMKNRVQRGLEKPKDTGFLKMMRSVFK 513
            .|||.:.|:|||.||||.:||:|:.||....|........:|..|
Mouse   473 KIFDVDKDDQLSYKEFIGIMKDRLHRGFRGYKTVQKYPTFKSCLK 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICU1	NP_001097110.1	EFh_MICU	272..492	CDD:320080	78/270 (29%)
		EF-hand motif	272..301	CDD:320080	12/28 (43%)
		EF-hand motif	326..425	CDD:320080	33/98 (34%)
		EF-hand motif	426..455	CDD:320080	8/28 (29%)
		EF-hand motif	463..492	CDD:320080	16/28 (57%)
Micu3	NP_084386.1	EFh_MICU3	229..496	CDD:320083	78/270 (29%)
		EF-hand motif	229..258	CDD:320083	12/28 (43%)
		EF-hand motif	334..364	CDD:320083	10/29 (34%)
		EF-hand motif	430..459	CDD:320083	8/28 (29%)
		EF-hand motif	467..496	CDD:320083	16/28 (57%)