Protein Alignment MICU1 and micu1

DIOPT Version :10

• Sequence 1: NP_001097110.1
• Gene: MICU1 / 33999
• FlyBaseID: FBgn0031893
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001077302.2
• Gene: micu1 / 561210
• ZFINID: ZDB-GENE-070410-22
• Length: 489
• Species: Danio rerio
• Alignment Length: 482
• Identity: 239/482 - (49%)
• Similarity: 321/482 - (66%)
• Gaps: 56/482 - (11%)

  Fly    49 LTKSSANLSLMQTRGHKRFG----HQEEKTPSVTKYFHMFILSLFLISVMDWGKVKRMLTPKVDA 109
            :|..||:..||.||.:...|    |:|:                           .|...|..|.
Zfish    42 VTGISASAGLMWTRAYAEAGSSVKHEEQ---------------------------MREEEPLKDV 79

  Fly   110 DAGQRPSSAADVNGEDKSSESESEDSEDEEAGSDLHLHEGKKIREKVGFRERKIIEYENRIRQFS 174
                  :..|:.:|..:||..|.||    |.||     |.||.::::|||:||::|||||||.:|
Zfish    80 ------AEEAESDGALESSSGEDED----EVGS-----EEKKKKQRIGFRDRKVMEYENRIRAYS 129

  Fly   175 TPDKVFRYFATIQVPVADDRHEVYMTPTDFLTSMTPGMKQPDGLGLDQY--RRYDPKSVGEQLNL 237
            ||||:||||||:::.......||||||.||:.|:||..|||:.|||||:  :|||.|...::::.
Zfish   130 TPDKIFRYFATLKIINEHGDAEVYMTPQDFVRSITPNEKQPENLGLDQFMVKRYDGKDFWQKISQ 194

  Fly   238 HLEK----NSIFYKLGSYGLITFSDYIFLLTVLSISRRHFEIAFRMFDLNGDGDVDCEEFEMVAT 298
            ..||    :||||.||..|||:|||||||.||||..:|:|||||:||||||||:||.||||.|.:
Zfish   195 DREKFADEDSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDLEEFEQVQS 259

  Fly   299 LVRQQTSMGTRHRDHANTGNTFK--GVNSALITYFFGPNMDEKLTIEKFLDFQEQLQREILSLEF 361
            ::|.|||||.||||.:.||||.|  |.:|||.|||||.::..||||..||:||.:||.::|.|||
Zfish   260 IIRSQTSMGMRHRDRSTTGNTLKTGGCSSALTTYFFGADLKGKLTISSFLEFQRKLQHDVLKLEF 324

  Fly   362 ERKEPNDEGNITEADFAELLLAYAGYPLKKKQKKLKRVKRRFRDHGKGISKQDYLDFFHFLNNIN 426
            ||.:|.| |.|||..|..:||||:|...:|.::..|.:||.|:| .:||:.::..:||.||.|:|
Zfish   325 ERNDPVD-GRITEKQFGGMLLAYSGVQSRKLKQMQKNLKRMFKD-AQGITFEEVENFFTFLKNVN 387

  Fly   427 DVDTALTFYHIAGASIDQQTLQHVAKTVAMVNLSDHVVDVVFTIFDENNDNQLSNKEFISVMKNR 491
            ||||||:|||:||||||:.|::.||:|||.|.|||||.||||.:||.:.:.:|||||||::||.|
Zfish   388 DVDTALSFYHMAGASIDKATMKQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFIAIMKQR 452

  Fly   492 VQRGLEKPKDTGFLKMMRSVFKCAKET 518
            :.||||||||.||.:::|:::|||::|
Zfish   453 LMRGLEKPKDMGFTRLVRAMWKCAQDT 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICU1	NP_001097110.1	EFh_MICU	272..492	CDD:320080	128/221 (58%)
		EF-hand motif	272..301	CDD:320080	20/28 (71%)
		EF-hand motif	326..425	CDD:320080	47/98 (48%)
		EF-hand motif	426..455	CDD:320080	20/28 (71%)
		EF-hand motif	463..492	CDD:320080	16/28 (57%)
micu1	NP_001077302.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..109		18/88 (20%)
		Polybasic region. /evidence=ECO:0000250|UniProtKB:Q9BPX6	106..117		4/10 (40%)
		K/R-ring. /evidence=ECO:0000250|UniProtKB:Q9BPX6	133..136		1/2 (50%)
		K/R-ring. /evidence=ECO:0000250|UniProtKB:Q9BPX6	270..274		3/3 (100%)
		C-helix region. /evidence=ECO:0000250|UniProtKB:Q9BPX6	467..477		3/9 (33%)