Protein Alignment MICU1 and MICU3

DIOPT Version :10

• Sequence 1: NP_001097110.1
• Gene: MICU1 / 33999
• FlyBaseID: FBgn0031893
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001262741.1
• Gene: MICU3 / 42357
• FlyBaseID: FBgn0038735
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 486
• Identity: 133/486 - (27%)
• Similarity: 205/486 - (42%)
• Gaps: 138/486 - (28%)

  Fly    98 KVKRMLTPKVDADAGQRPSSAADVNGEDKSSESE----------SEDSEDEEAGSDLHLHEGKKI 152
            |.:|:|| .|...|....:.||.:  :.:|:|:.          .:|||.|..
  Fly    46 KTRRLLT-IVGGSAVSLAALAAFI--KLRSAENPVNAVSLKRRMRDDSELENV------------ 95

  Fly   153 REKVGFRERKIIEYENRIRQFSTPDKVFRYFATIQVPVADDRHEVYMTPTDFLTSMT-----PGM 212
              |:..|||:.|:                 ||:::.   ||  ::||||.|||.|:.     |.:
  Fly    96 --KLTARERRFIK-----------------FASVEY---DD--QLYMTPQDFLDSVVEQEPRPRL 136

  Fly   213 K--QPDGLGLDQYRRYDPKSVGEQLNLHLEKNS--IFYKLGSYGLITFSDYIFLLTVLSISRRHF 273
            |  |.....:|:|:...|.         |:|.|  :|..|...|::::::|:|||::|:..:..|
  Fly   137 KRRQLSSDEVDKYKENTPA---------LKKGSTRLFRNLRDKGIVSYTEYLFLLSILTKPKSGF 192

  Fly   274 EIAFRMFDLNGDGDVDCEEF-----------------------------------EMVATLVRQQ 303
            .|||.|||.:|:..||.:||                                   :|...:...|
  Fly   193 RIAFNMFDTDGNQRVDKDEFLVIISILAGALKDTQNVDPQTKRILSRLVSYDEQSQMTKPMAVPQ 257

  Fly   304 TSMGTRHR---------------------------DHANTGNTFKG---VNSALITYFFGPNMDE 338
            ...|...|                           ::.|.|...:.   |.:.|..:|||.....
  Fly   258 AKRGIMERIFSGAWKEKHGEQEPEEELATPTPLEQNYVNDGEGLQRRHMVATTLQLHFFGKRGTG 322

  Fly   339 KLTIEKFLDFQEQLQREILSLEFERKEPNDEGN--ITEADFAELLLAYAGYPLKKKQKKLKRVKR 401
            .:..:.|..|.:.||.|:|.|||..   ..:||  |:|.|||::||.|......:....|:|:..
  Fly   323 VINYDNFYRFMDNLQTEVLELEFHE---FSKGNSVISELDFAKILLRYTYLATDEYDVFLERLLE 384

  Fly   402 RFRDHGKGISKQDYLDFFHFLNNINDVDTALTFYHIAGASIDQQTLQHVAKTVAMVNLSDHVVDV 466
            |.:|. ||||..|:.||.|||||::|...|:..|.:|..:|.:.......|......||.|::|.
  Fly   385 RVKDE-KGISFHDFRDFCHFLNNLDDFTIAMRMYTLADRAISKDEFSRAVKICTGYKLSPHLIDT 448

  Fly   467 VFTIFDENNDNQLSNKEFISVMKNRVQRGLE 497
            ||.|||.:.|..||.||||::||:|:.||.:
  Fly   449 VFAIFDADGDGLLSYKEFIAIMKDRLHRGFK 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICU1	NP_001097110.1	EFh_MICU	272..492	CDD:320080	82/286 (29%)
		EF-hand motif	272..301	CDD:320080	13/63 (21%)
		EF-hand motif	326..425	CDD:320080	38/100 (38%)
		EF-hand motif	426..455	CDD:320080	6/28 (21%)
		EF-hand motif	463..492	CDD:320080	15/28 (54%)
MICU3	NP_001262741.1	EFh_MICU	191..474	CDD:333716	82/286 (29%)
		EF-hand motif	191..220	CDD:320080	12/28 (43%)
		EF-hand motif	310..340	CDD:320080	8/29 (28%)
		EF-hand motif	408..437	CDD:320080	6/28 (21%)
		EF-hand motif	445..474	CDD:320080	15/28 (54%)