Protein Alignment MICU1 and Micu1

DIOPT Version :10

• Sequence 1: NP_001097110.1
• Gene: MICU1 / 33999
• FlyBaseID: FBgn0031893
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001278371.1
• Gene: Micu1 / 216001
• MGIID: 2384909
• Length: 483
• Species: Mus musculus
• Alignment Length: 511
• Identity: 243/511 - (47%)
• Similarity: 329/511 - (64%)
• Gaps: 53/511 - (10%)

  Fly    22 LNIIQNPAQIAYASTLCNQNSNHNAKDLTKSSANLSLMQTRGHKRFGHQEEKTPSVTKYFHMFIL 86
            ||.:...|::|..|     ...|.|...|::...|.|:...|          ..:||       .
Mouse     4 LNTLSALAELAVGS-----RWYHGASQPTQTKRRLMLVAFLG----------ASAVT-------A 46

  Fly    87 SLFLISVMDWGKVKRMLTPKVDADAGQRPSSAADVNGEDK-----SSESESEDSEDEEAGSDLHL 146
            |..|:    |.|......|.|::   ::|.:      |||     |.|..|.:....:|.::.:.
Mouse    47 STGLL----WKKAHAESPPCVNS---KKPDT------EDKERNKDSGEVSSREGRAADAAAEPYP 98

  Fly   147 HEGKKIREKVGFRERKIIEYENRIRQFSTPDKVFRYFATIQVPVADDRHEVYMTPTDFLTSMTPG 211
            .:.||.|.  |||:||::|||||||.:|||||:||||||::|.......||:|||.||:.|:||.
Mouse    99 EDKKKKRS--GFRDRKVMEYENRIRAYSTPDKIFRYFATLKVINEPGETEVFMTPQDFVRSITPN 161

  Fly   212 MKQPDGLGLDQY--RRYDPK------SVGEQLNLHLEKNSIFYKLGSYGLITFSDYIFLLTVLSI 268
            .|||:.||||||  :|:|.|      .:.::.....::.||||.||..|||:|||||||.||||.
Mouse   162 EKQPEHLGLDQYIIKRFDGKEFWQTEKIAQEREKFADEGSIFYSLGECGLISFSDYIFLTTVLST 226

  Fly   269 SRRHFEIAFRMFDLNGDGDVDCEEFEMVATLVRQQTSMGTRHRDHANTGNTFK-GVNSALITYFF 332
            .:|:|||||:||||||||:||.||||.|.:::|.|||||.||||...||||.| |:.|||.||||
Mouse   227 PQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFF 291

  Fly   333 GPNMDEKLTIEKFLDFQEQLQREILSLEFERKEPNDEGNITEADFAELLLAYAGYPLKKKQKKLK 397
            |.::..||||:.||:||.:||.::|.|||||.:|.| |.|:|..|..:||||:|...||.....:
Mouse   292 GADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVD-GRISERQFGGMLLAYSGVQSKKLTAMQR 355

  Fly   398 RVKRRFRDHGKGISKQDYLDFFHFLNNINDVDTALTFYHIAGASIDQQTLQHVAKTVAMVNLSDH 462
            ::|:.|:| |||::.|:..:||.||.|||||||||:|||:||||:|:.|:|.||:|||.|.||||
Mouse   356 QLKKHFKD-GKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDH 419

  Fly   463 VVDVVFTIFDENNDNQLSNKEFISVMKNRVQRGLEKPKDTGFLKMMRSVFKCAKET 518
            |.||||.:||.:.:.:||||||:|:||.|:.||||||||.||.::|::::|||:||
Mouse   420 VCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQET 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICU1	NP_001097110.1	EFh_MICU	272..492	CDD:320080	129/220 (59%)
		EF-hand motif	272..301	CDD:320080	20/28 (71%)
		EF-hand motif	326..425	CDD:320080	47/98 (48%)
		EF-hand motif	426..455	CDD:320080	20/28 (71%)
		EF-hand motif	463..492	CDD:320080	16/28 (57%)
Micu1	NP_001278371.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..107		13/60 (22%)
		Polybasic region. /evidence=ECO:0000250|UniProtKB:Q9BPX6	101..112		6/12 (50%)
		K/R-ring. /evidence=ECO:0000250|UniProtKB:Q9BPX6	128..131		1/2 (50%)
		EFh_MICU1	230..449	CDD:320081	129/220 (59%)
		EF-hand motif	230..259	CDD:320081	20/28 (71%)
		K/R-ring. /evidence=ECO:0000250|UniProtKB:Q9BPX6	267..271		3/3 (100%)
		EF-hand motif	285..315	CDD:320081	17/29 (59%)
		EF-hand motif	383..412	CDD:320081	20/28 (71%)
		EF-hand motif	420..449	CDD:320081	16/28 (57%)
		C-helix region. /evidence=ECO:0000250|UniProtKB:Q9BPX6	463..473		3/9 (33%)