Protein Alignment MICU1 and micu2

DIOPT Version :10

• Sequence 1: NP_001097110.1
• Gene: MICU1 / 33999
• FlyBaseID: FBgn0031893
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: XP_002940795.2
• Gene: micu2 / 100486652
• XenbaseID: XB-GENE-994925
• Length: 431
• Species: Xenopus tropicalis
• Alignment Length: 414
• Identity: 112/414 - (27%)
• Similarity: 182/414 - (43%)
• Gaps: 94/414 - (22%)

  Fly   130 SESEDSEDEEAGSDLHLHEGKKIREKVGFRERKIIEYENRIRQFSTPDKVFRYFATIQVPVADDR 194
            ::.||:.||       ..|.:.|| |..|.:...::||.
 Frog    66 AQKEDANDE-------AKENQSIR-KQRFMQFASLKYEG-------------------------- 96

  Fly   195 HEVYMTPTDFLTSMTPGMKQPDGLGLDQYRRYDPKSVGEQLN-----------LHLEKNSIFYK- 247
             |.||||.|||.|:             .:.:.:.:::.:.|.           ...:..|:|::
 Frog    97 -EYYMTPRDFLFSV-------------MFEQMERRTISKPLTKKELDAMLSQATKAKPGSMFFRD 147

  Fly   248 LGSYGLITFSDYIFLLTVLSISRRHFEIAFRMFDLNGDGDVDCEEFEMVATLVRQQTSM-----G 307
            ||..|||::::|:||||:|:..:..|.|||.|.|.:|:..|:..||..:..::..:..|     |
 Frog   148 LGDKGLISYTEYLFLLTILTKPQTGFRIAFNMLDTDGNEQVEKREFFKLQRILGHKEDMKMSPGG 212

  Fly   308 TRHRDHANTGNTFKGVNSALITYFFGPNMDEKLTIEKFLDFQEQLQREILSLE---------FER 363
            .......:|.::  .||:.|:.:|||....|||...:|..|.|.||.|:..:|         |.|
 Frog   213 VTSTQEPSTDSS--DVNTTLLVHFFGRGGREKLQYSEFYKFMENLQTEVQEMEFIQFSKGLNFMR 275

  Fly   364 KEPNDEGNITEADFAELLLAYAGYPLKKKQKKLKRVKRRFRDHGKGISKQDYLDFFHFLNNINDV 428
            ||          ||||.||.:...  :......:.|:.|. ..|:.||..::..|:.|:||:.|.
 Frog   276 KE----------DFAEWLLFFTDE--ENNDVYWQNVQARI-PPGESISMDEFKSFYQFMNNLEDF 327

  Fly   429 DTALTFYHIAGASIDQQTLQHVAKTVAMVNLSDHVVDVVFTIFDENNDNQLSNKEFISVMKNRVQ 493
            ...:..:..|..:|.....:...|......||::|:|.||.|||.:.||.||:.||:.|::||:.
 Frog   328 SITMKLFSSANRAIKMAEFKRAVKVATGQELSNNVLDTVFKIFDLDGDNCLSHGEFLGVLRNRLH 392

  Fly   494 RGLEK-PKDTGFLKMMRSVFKCAK 516
            |||:. |:..|    :...:||.|
 Frog   393 RGLKHVPQQQG----VHGYWKCVK 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICU1	NP_001097110.1	EFh_MICU	272..492	CDD:320080	69/233 (30%)
		EF-hand motif	272..301	CDD:320080	10/28 (36%)
		EF-hand motif	326..425	CDD:320080	32/107 (30%)
		EF-hand motif	426..455	CDD:320080	4/28 (14%)
		EF-hand motif	463..492	CDD:320080	15/28 (54%)
micu2	XP_002940795.2	FRQ1	80..198	CDD:444056	39/158 (25%)
		EFh_MICU2	172..391	CDD:320082	69/233 (30%)
		EF-hand motif	172..201	CDD:320082	10/28 (36%)
		EF-hand motif	229..259	CDD:320082	12/29 (41%)
		EF-hand motif	325..354	CDD:320082	4/28 (14%)
		EF-hand motif	362..391	CDD:320082	15/28 (54%)