Protein Alignment SA1 and Stag3

DIOPT Version :10

• Sequence 1: NP_477268.2
• Gene: SA1 / 33974
• FlyBaseID: FBgn0020616
• Length: 1127
• Species: Drosophila melanogaster
• Sequence 2: NP_058660.2
• Gene: Stag3 / 50878
• MGIID: 1355311
• Length: 1240
• Species: Mus musculus
• Alignment Length: 1120
• Identity: 428/1120 - (38%)
• Similarity: 672/1120 - (60%)
• Gaps: 75/1120 - (6%)

  Fly    25 DALNESTSDADSPTKRMTRLRARGGVRDKPPIIDDDEDDFFAPIARKRKTPATRKGPTERKERVE 89
            |..::.|::.|||:...                |.|.:|......:||......|.....|.|.:
Mouse    46 DRDSQGTAEWDSPSTNE----------------DSDFEDSLRRNVKKRAAKQPPKAVPAAKHRKK 94

  Fly    90 RPRKEPVDKGHHERIDSEREITTDENSLYYIVRHSKNPIASIVDQWIEQYKANRETALVALMQFF 154
            :.|......|.:|.:.|       .|.|:..|:.:::.:.|:||:|::.||.:.....:.|:.||
Mouse    95 QSRIVSSGNGKNESVPS-------TNYLFDAVKAARSCMQSLVDEWLDNYKQDENAGFLELINFF 152

  Fly   155 INASGCKGKISEDIQYPVDHTSIIRRMTEEFDEESGEYPLIMSGTQWRKFKNNFCDFVQTLVKQC 219
            |.|.|||..::.::...:.::.||:.:||||:|:||:|||...|..|:||:.:||:||:|||.||
Mouse   153 IRACGCKSTVTPEMFKTMSNSEIIQHLTEEFNEDSGDYPLTAPGPSWKKFQGSFCEFVKTLVYQC 217

  Fly   220 QYSIIYDQFLMDNVISLLTGLSDSQVRAFRHTATLAAMKLMTALVDVALLVSNNFDNAAKQFEAE 284
            |||::||.|.||::||||.|||||||||||||:|||||||||:||.|||.:|.:.||..:|:|||
Mouse   218 QYSLLYDGFPMDDLISLLIGLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSLHKDNNQRQYEAE 282

  Fly   285 RVKSRDRRASDRLDSLMTKRSELEENMDEIKSMLTYMFKSVFVHRYRDSLPDIRAICMAEIGIWM 349
            |.|..::||.:||:||:.||.|.:||.::|:.|:..:|:.||||||||.||:|||||:.|||.||
Mouse   283 RNKGPEQRAPERLESLLEKRKEFQENQEDIEGMMNAIFRGVFVHRYRDILPEIRAICIEEIGYWM 347

  Fly   350 ENYPQNFLDDSYLKYIGWTLHDKIGEVRLRCLQSLLPLYEKDELKGKLELFTSKFKDRIVAMTLD 414
            ::|..:||:||||||||||||||..||||:|:::|..||...||..::||||::||||:|:|.:|
Mouse   348 QSYSTSFLNDSYLKYIGWTLHDKHKEVRLKCVKALAGLYSNQELSLRMELFTNRFKDRMVSMVMD 412

  Fly   415 KEFEVSVHAVKLVISILKIHPEILADKDCEIVYELVYSSHRGVAQAAAEFLNVRLFH------LT 473
            :|.||:|.|::|:..|||....:|...|||.:|.:||.|:|.:|.:|.||:..::||      ..
Mouse   413 RECEVAVEAIRLLTLILKNMEGVLTSADCEKIYSIVYISNRAMASSAGEFVYWKIFHPECGAKAV 477

  Fly   474 ADMEETKTKRGKVRMPNTPLVRDLVQFFIESELHEHGAYLVDSFID-SNDMVRDWECMTDLLLEE 537
            :|.|..::.:.:     ...:..|:.||:|||.|.|.||||||..| :...::|||.:|:|||::
Mouse   478 SDRERRRSPQAQ-----KTFIYLLLAFFMESEHHNHAAYLVDSLWDCAGSYLKDWESLTNLLLQK 537

  Fly   538 PGPNEEVLDNKQESTLIEIMVSSVKQSATGEVPVGRASNRKCTLSAKELKAIQDEKAKLTEHFIV 602
                ::.|.:.||..||||:|||.:|:|.|..||||.:.:| :|:|||.|....:|.||.||.|.
Mouse   538 ----DQNLGDMQERMLIEILVSSARQAAEGHPPVGRITGKK-SLTAKERKLQAYDKMKLAEHLIP 597

  Fly   603 TLPSLLEKYQADSEKLANLLAVPQYFDLNLYTTNRQEGNLQALLDRINQVMSMHTGREVLETCAK 667
            .||.||.|:.||:|.:|.||.:..||||::|.|.|.|.:|:.||.::.:|:..|...||||..|.
Mouse   598 LLPQLLAKFSADAENVAPLLQLLSYFDLSIYCTQRLEKHLELLLQQLQEVVVKHVEPEVLEAAAH 662

  Fly   668 TLECLCAEGSATYTRCNIARSNIIESAVNKYKDAIEEWRNLIQGEETPNEDDIYNITITLKVLSI 732
            .|..||......::|.:.|||.:::...::::..:::   |:|.... :||::|::|.|||.||.
Mouse   663 ALYLLCKPEFTFFSRVDFARSQLVDFLTDRFQQELDD---LMQSSFL-DEDEVYSLTATLKRLSA 723

  Fly   733 LYSSHNLNPWELFKSLFQDVEEAQSKENIDRCLPNEALVYCIEACYFSISWGLQYVENECESVNV 797
            .|::|:|..||:.:...:.:.:|.....:    |::.::..:...||||.|.:.::.   ||.:.
Mouse   724 FYNAHDLTRWEISEPCSRLLRKAVDTGEV----PHQVILPALTLVYFSILWTVTHIS---ESTSH 781

  Fly   798 TEVVAELRNNLDTFMGACFELTRD-GPTVQIQEAAYQSICDLLIIFSDKLARSEIEHIRGLEYKS 861
            .:::: |:..:..|...|.....| .|  :|||.|:..:.|||:|||.::.....:.:|.|.:..
Mouse   782 KQLMS-LKKRMVAFCELCQSCLSDVDP--EIQEQAFVLLSDLLLIFSPQMIVGGRDFLRPLVFFP 843

  Fly   862 RMDEHLILDNFVQHYVFSLKQDVA-----QDETRIEELHKKRNFLACYCKLVVYNIIPTMRAASI 921
            .......|.:|:..:||....::.     :|..:||.||::|..||.:|||::|.::....|:.:
Mouse   844 EATLQSELASFLMDHVFLQPGELGNGQSQEDHVQIELLHQRRRLLAGFCKLLLYGVLELDAASDV 908

  Fly   922 FKYYVKCYNDYGDIIKATLGKAREINKVNFAMTLLLSLITVFKSL-QEQSEDGIVSKSSQEFVDL 985
            ||:|.|.|.|||||||.||.:||:|::...:..|||||..::..| |||...|:....:  |:::
Mouse   909 FKHYNKFYEDYGDIIKETLTRARQIDRCQCSRILLLSLKQLYTELIQEQGPQGLTELPA--FIEM 971

  Fly   986 KELAKRFALTFGFDAIKNRESVAAIHRGGIYFAANK-EPDDPVRAPTRLLFLEVLNEFNYKLLKQ 1049
            ::||:||||:||...:.||:.|..:|:.||.|:.:: .|......|..|.|||:|:||:.:|..|
Mouse   972 RDLARRFALSFGPQQLHNRDLVVMLHKEGIKFSLSELPPAGSSHEPPNLAFLELLSEFSPRLFHQ 1036

  Fly  1050 DKKVIMSFLDKIIPPAMPSSRA--EEWQPLILYRNSLLHGE-TDQA-----PVASKRAYTRKRRD 1106
            ||::::|:|:|.:...   |:|  ..|.|:..|.:||...| |.:|     |.:.||......|.
Mouse  1037 DKRLLLSYLEKCLQRV---SKAPNHPWGPVTTYCHSLHPLEITAEASPRGPPHSKKRCVEGPCRP 1098

  Fly  1107 HDEEEEEEEDEEEHN 1121
            .:||...:|:..:.|
Mouse  1099 QEEESSSQEESLQLN 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SA1	NP_477268.2	IRR1	66..>426	CDD:227824	176/359 (49%)
		STAG	190..303	CDD:462502	71/112 (63%)
Stag3	NP_058660.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..108		15/77 (19%)
		IRR1	56..>426	CDD:227824	183/392 (47%)
		STAG	188..301	CDD:462502	71/112 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1077..1154		9/37 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1213..1240