Protein Alignment SA1 and scc-3

DIOPT Version :10

• Sequence 1: NP_477268.2
• Gene: SA1 / 33974
• FlyBaseID: FBgn0020616
• Length: 1127
• Species: Drosophila melanogaster
• Sequence 2: NP_506193.1
• Gene: scc-3 / 179749
• WormBaseID: WBGene00004738
• Length: 1096
• Species: Caenorhabditis elegans
• Alignment Length: 1130
• Identity: 381/1130 - (33%)
• Similarity: 615/1130 - (54%)
• Gaps: 117/1130 - (10%)

  Fly    27 LNESTSDADSPTKRMTRLRARGGVRD---------KPPIIDDDEDDFFAPIARKRKTPATRKGPT 82
            ::|:.:| .||.:..||.:||....|         |.|:.              |...|:.:|..
 Worm     1 MSETPTD-QSPQRMSTRNQARVNYTDMAAGNNSVEKEPVF--------------RSPTASTRGRK 50

  Fly    83 ERKERVE---------------------RPRKEPVDKGHHERIDSEREITTDENS------LYYI 120
            :|...|:                     |||...:......|....|..||:|::      |...
 Worm    51 KRAANVDVADLSASFGNLNNFSTPPKRGRPRGGGLGSARGGRAPMVRRTTTEESAEVDDRELVAA 115

  Fly   121 VRHSKNPIASIVDQWIEQYKANRETALVALMQFFINASGCKGKISEDIQYPVDHTSIIRRMTEEF 185
            |:..|. |...||:||.:|......|:..:.|||....||||.::..:...:.:..||.||||:|
 Worm   116 VKSGKK-ITEAVDRWIGRYNEKFLVAIAEMHQFFFAICGCKGIVTPQMSATLTYKDIICRMTEDF 179

  Fly   186 DEESGEYPLIMSGTQWRKFKNNFCDFVQTLVKQCQYSIIYDQFLMDNVISLLTGLSDSQVRAFRH 250
            :|:|.:|||:..|: .:|.:.|..:|:.||:.:.:.|:::|..|||..:.||||::|||||||||
 Worm   180 EEDSADYPLVHGGS-LKKVRANLHNFIHTLIIRTKASMLFDSNLMDGFVQLLTGMADSQVRAFRH 243

  Fly   251 TATLAAMKLMTALVDVALLVSNNFDNAAKQFEAERVKSRDRRA-SDRLDSLMTKRSELEENMDEI 314
            |||..|||:.:|||||.:.::.:.:..:||.|||:.|.::..| :::.::|:.:|::.||..:||
 Worm   244 TATFCAMKITSALVDVTIELTQSKEKTSKQIEAEKAKLKNNSAGNEKYEALVAQRTQTEERAEEI 308

  Fly   315 KSMLTYMFKSVFVHRYRDSLPDIRAICMAEIGIWMENYPQNFLDDSYLKYIGWTLHDKIGEVRLR 379
            :.::.|:|:|||||||||.:||||.||:.|:|.||:.||::|::|||||||||::.||:|:||.|
 Worm   309 RQIIGYLFRSVFVHRYRDVVPDIRCICIQELGHWMDVYPEHFVEDSYLKYIGWSMFDKVGDVRQR 373

  Fly   380 CLQSLLPLYEKDELKGKLELFTSKFKDRIVAMTLDKEFEVSVHAVKLVISILKIHPEILADKDCE 444
            |:::|:||:||..:..|||||.:|||||:|:|.|||:.|.|:..|.|:..:..:.|.:|..||..
 Worm   374 CIRALIPLFEKTLILDKLELFVNKFKDRLVSMLLDKDLETSIETVHLMRVLYTVFPTLLTIKDVV 438

  Fly   445 IVYELVYSSHRGVAQAAAEFLNVRLFHLTADMEETKTKRGKV-RMPNTPLVRDLVQFFIESELHE 508
            .:|||:|:|:|.:|.||..|||.::|       .:..|.||. ...|.|||:||..||||.:||:
 Worm   439 PIYELIYASNRPLAVAAGMFLNTKVF-------RSAEKPGKAPTAANIPLVKDLTTFFIEGDLHQ 496

  Fly   509 HGAYLVDSFIDSNDMVRDWECMTDLLLEEPGPNEEVLDNKQESTLIEIMVSSVKQSATGEVPVGR 573
            |..||||:..:||.:|:||..|.:||:.:    :..||:..|:.||||:..||.||||||.||||
 Worm   497 HATYLVDALFESNPIVKDWATMGELLIND----QYQLDSNFETKLIEILTCSVVQSATGEPPVGR 557

  Fly   574 ASNRKCTLSAKELKAIQDEKAKLTEHFIVTLPSLLEKYQADSEKLANLLAVPQYFDLNLYTTNRQ 638
            ...:|...||||.:.:.:::.:|||..|..:|.|:.|:.:|:||:.||:.:|.:|.|..|.:.|.
 Worm   558 HIVKKGAPSAKESRDLVEDRQRLTETLIPLIPRLITKFSSDNEKIINLVNIPLHFQLETYLSARM 622

  Fly   639 EGNLQALLDRINQVMSMHTGREVLETCAKTLECLCAEGSATYTRCNIARSNIIESAVNKYKDAIE 703
            :.:|..|::.::.::..|...|:|:..|:....|....|.         |.::|....|..|.:.
 Worm   623 QTHLMELMEGLDSLIEKHLDEELLKAVAELYYHLTTNSSI---------SALVEGHKMKLLDGVA 678

  Fly   704 EW-RNLIQ-------GEETPNEDDIYNITITLKVLSILYSSHNLNPWELFKSLFQDVEEAQSKEN 760
            .: |..:|       |||   |:.::  ...:|.::......:|..|:|:..|.:.|.. .::|:
 Worm   679 AFIRKSMQQFDDDQMGEE---EEALF--VSYIKRMAAFAGFMDLRHWDLWDILLKVVSN-YTRED 737

  Fly   761 IDRCLPNEAL-VYCIEACYFSISWGLQYVENECESVNVTEVVAELRNNLDTFMGACFE-LTRDGP 823
            ..|.:...:: :..::.|:.|::     ::.|.|:....: |.:|:...|..:....| |..:..
 Worm   738 TQRDVRERSMQMLFMQLCFDSMN-----IKKEGETPKADQ-VRKLKKRRDQLIRIVTETLNEEAC 796

  Fly   824 TVQIQEAAYQSICDLLIIFSDKLARSEIEHIRGLEYKSRMDEHLILDN---FVQHYVFSLK--QD 883
            .|   |.||..||||:|:|..:||    |..:.||......:.::|.|   |:...||.:.  .|
 Worm   797 GV---EQAYLVICDLMILFGSQLA----EESKALEPLIWRPDAMVLGNLKIFLDVNVFDVSNLDD 854

  Fly   884 VAQDETRIEELHKKRNFLACYCKLVVYNIIPTMRAASIFKYYVKCYNDYGDIIKATLGKAREINK 948
            :.|.| :||.:||.|..:|.|.||:::..:|...|:.:.|.|...:.|:|||.|..|.|.|||:.
 Worm   855 MDQQE-KIEVMHKMRQHVAQYAKLIIHGAMPVAEASHLIKRYQSHFQDFGDIFKNLLSKCREISF 918

  Fly   949 VNFAMTLLLSLITVFKSLQE-QSEDGIVSKSSQEFVDLKELAKRFALTFGFDAIKNRESVAAIHR 1012
            |...:.:..:|.|::..|.| |..|.:    |:.|..:::||||....||.|..|||.:::::|:
 Worm   919 VETGVMICETLKTLYSQLDEDQGTDPL----SESFNSIRDLAKRLGPAFGVDYAKNRFAISSLHK 979

  Fly  1013 GGIYFAANKEPDDPVRAPTRLLFLEVLNEFNYKLLKQDKKVIMSFLDKIIPPAMPSSRAEEWQPL 1077
            ..|.||..:...:..:.|..:.|||:..||:.|||.|||..::.:|:||....:.:|.. .|:|.
 Worm   980 KAIDFAFEEYDKENHQMPKNIFFLEIAIEFSGKLLAQDKMAVVRYLNKIYTNRVGTSTV-VWEPY 1043

  Fly  1078 ILYRNSLL-HGETDQAPVASKRAYT 1101
            .||..||. ..:.|...|.|....|
 Worm  1044 RLYLGSLSDRNDDDNMSVRSGMTVT 1068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SA1	NP_477268.2	IRR1	66..>426	CDD:227824	153/387 (40%)
		STAG	190..303	CDD:462502	46/113 (41%)
scc-3	NP_506193.1	IRR1	93..>406	CDD:227824	137/314 (44%)
		STAG	184..286	CDD:462502	44/102 (43%)